WFRF:(Xiang LG)
Sökning: WFRF:(Xiang LG) > (2005-2009) > The kinase domain o...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02384naa a2200457 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:1962096 | |
| 003 | SwePub | |
| 008 | 240811s2005 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:19620962 URI |
| 024 | 7 | a https://doi.org/10.1126/science.11104632 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Lange, S4 aut |
| 245 | 1 0 | a The kinase domain of titin controls muscle gene expression and protein turnover |
| 264 | 1 | b American Association for the Advancement of Science (AAAS),c 2005 |
| 520 | a The giant sarcomeric protein titin contains a protein kinase domain (TK) ideally positioned to sense mechanical load. We identified a signaling complex where TK interacts with the zinc-finger protein nbr1 through a mechanically inducible conformation. Nbr1 targets the ubiquitin-associated p62/SQSTM1 to sarcomeres, and p62 in turn interacts with MuRF2, a muscle-specific RING-B-box E3 ligase and ligand of the transactivation domain of the serum response transcription factor (SRF). Nuclear translocation of MuRF2 was induced by mechanical inactivity and caused reduction of nuclear SRF and repression of transcription. A human mutation in the titin protein kinase domain causes hereditary muscle disease by disrupting this pathway. | |
| 700 | 1 | a Xiang, FQu Karolinska Institutet4 aut |
| 700 | 1 | a Yakovenko, A4 aut |
| 700 | 1 | a Vihola, A4 aut |
| 700 | 1 | a Hackman, P4 aut |
| 700 | 1 | a Rostkova, E4 aut |
| 700 | 1 | a Kristensen, J4 aut |
| 700 | 1 | a Brandmeier, B4 aut |
| 700 | 1 | a Franzen, G4 aut |
| 700 | 1 | a Hedberg, B4 aut |
| 700 | 1 | a Gunnarsson, LG4 aut |
| 700 | 1 | a Hughes, SM4 aut |
| 700 | 1 | a Marchand, S4 aut |
| 700 | 1 | a Sejersen, Tu Karolinska Institutet4 aut |
| 700 | 1 | a Richard, I4 aut |
| 700 | 1 | a Edstrom, L4 aut |
| 700 | 1 | a Ehler, E4 aut |
| 700 | 1 | a Udd, B4 aut |
| 700 | 1 | a Gautel, M4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Science (New York, N.Y.)d : American Association for the Advancement of Science (AAAS)g 308:5728, s. 1599-1603q 308:5728<1599-1603x 1095-9203x 0036-8075 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:1962096 |
| 856 | 4 8 | u https://doi.org/10.1126/science.1110463 |
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- Lange, S
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