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Genetic variants an...
Genetic variants and Expression of Cytochrome p450 Oxidoreductase Predict Postoperative Survival in Patients with Hepatitis B Virus-Related Hepatocellular Carcinoma
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- Huang, Ketuan (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.
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- Liao, Xiwen (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.
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- Han, Chuangye (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.
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- Wang, Xiangkun (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.
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- Yu, Tingdong (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.
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- Yang, Chengkun (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.
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- Liu, Xiaoguang (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.;Guangdong Med Univ, Affiliated Hosp, Dept Hepatobiliary Surg, Zhanjiang 524001, Guangdong, Peoples R China.
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- Yu, Long (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.;Zhengzhou Univ, Affiliated Hosp 1, Dept Hepatobiliary & Pancreat Surg, Zhengzhou 450000, Henan, Peoples R China.
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- Chen, Zhiwei (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.
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- Qin, Wei (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.
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- Zhu, Guangzhi (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.
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- Su, Hao (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.
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- Liu, Zhengqian (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.
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- Zeng, Xianmin (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.
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- Zhou, Xin (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.
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- Lu, Sicong (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.
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- Huang, Jianlv (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.;Guangxi Med Univ, Affiliated Hosp 3, Dept Hepatobiliary Surg, Nanning 530031, Guangxi, Peoples R China.
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- Liang, Yu (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.
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- Liu, Zhengtao (author)
- KTH,Science for Life Laboratory, SciLifeLab
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- Deng, Jianlong (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.;Guangxi Med Univ, Affiliated Hosp 6, Dept Hepatobiliary Surg, Yulin 537000, Guangxi, Peoples R China.
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- Ye, Xinping (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.
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- Peng, Tao (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.
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Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.;Guangdong Med Univ, Affiliated Hosp, Dept Hepatobiliary Surg, Zhanjiang 524001, Guangdong, Peoples R China. (creator_code:org_t)
- IVYSPRING INT PUBL, 2019
- 2019
- English.
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In: Journal of Cancer. - : IVYSPRING INT PUBL. - 1837-9664. ; 10:6, s. 1453-1465
- Related links:
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https://www.jcancer....
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https://urn.kb.se/re...
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https://doi.org/10.7...
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Abstract
Subject headings
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- Our current study investigates the prognostic values of genetic variants and mRNA expression of cytochrome p450 oxidoreductase (POR) in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). A total of 19 candidate single nucleotide polymorphisms (SNPs) located in the exons of POR were genotyped using Sanger sequencing from 476 HBV-related HCC patients who underwent hepatectomy between 2003 and 2013. The mRNA expression of POR in 212 patients with HBV-related HCC was obtained from GSE14520 dataset. Survival analysis was performed to investigate the association of POR variants and mRNA expression with overall survival (OS) and recurrence-free survival (RFS). Nomograms were used to predict the prognosis of HBV-related HCC patients. Gene set enrichment analysis (GSEA) was used to investigate the mechanism of POR in HBV-related HCC prognosis. The polymorphism POR-rs1057868 was significantly associated with HBV-related HCC OS (CT/TT vs. CC, hazard ratio [HR] = 0.69, 95% confidence interval [CI] = [0.54, 0.88], P = 0.003), but not significantly associated with RFS (CT/TT vs. CC, P = 0.378). POR mRNA expression was also significantly associated with HBV-related HCC OS (high vs. low, HR = 0.61, 95% CI = [0.38, 0.97], P= 0.036), but not significantly associated with the RFS (high vs. low, P = 0.201). Two nomograms were developed to predict the HBV-related HCC OS. Furthermore, GSEA suggests that multiple gene sets were significantly enriched in liver cancer survival and recurrence, as well as POR-related target therapy in the liver. In conclusion, our study suggests that POR-rs1057868 and mRNA expression may serve as a potential postoperative prognosis biomarker in HBV-related HCC.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Keyword
- hepatocellular carcinoma
- cytochrome p450 oxidoreductase
- prognosis
- hepatitis B virus
- hepatectomy
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Huang, Ketuan
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Liao, Xiwen
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Han, Chuangye
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Wang, Xiangkun
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Yu, Tingdong
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Yang, Chengkun
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show more...
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Liu, Xiaoguang
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Yu, Long
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Chen, Zhiwei
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Qin, Wei
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Zhu, Guangzhi
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Su, Hao
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Liu, Zhengqian
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Zeng, Xianmin
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Zhou, Xin
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Lu, Sicong
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Huang, Jianlv
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Liang, Yu
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Liu, Zhengtao
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Deng, Jianlong
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Ye, Xinping
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Peng, Tao
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
- Articles in the publication
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Journal of Cance ...
- By the university
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Royal Institute of Technology