WFRF:(Yeh R)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04118naa a2200733 4500 | |
| 001 | oai:gup.ub.gu.se/75505 | |
| 003 | SwePub | |
| 008 | 240528s2003 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/755052 URI |
| 024 | 7 | a https://doi.org/10.1002/jnr.106942 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Ericson, Mia,d 1970u Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap, Sektionen för psykiatri,Institute of Clinical Neurosciences, Section of Psychiatry4 aut0 (Swepub:gu)xerimi |
| 245 | 1 0 | a Brain-derived neurotrophic factor mitigates chronic ethanol-induced attenuation of gamma-aminobutyric acid responses in cultured cerebellar granule cells. |
| 264 | c 2003-08-14 | |
| 264 | 1 | b Wiley,c 2003 |
| 520 | a This study examined the effect of chronic exposure to ethanol and brain-derived neurotrophic factor (BDNF) on the responsiveness of cerebellar granule cells to gamma-aminobutyric acid (GABA). Cerebellar granule cell cultures were chronically exposed to ethanol (100 mM), BDNF (20 ng/ml), or the combination of ethanol and BDNF. Whole-cell current responses of granule cells to exogenously applied GABA were monitored following at least 5 days of chronic exposure. In the ethanol-treated cultures, granule cell responsiveness to GABA was attenuated. Concomitant exposure of cultures to ethanol and BDNF mitigated the ethanol-induced attenuation of GABA response, although BDNF, by itself, did not affect responsiveness to GABA. BDNF increased the expression of the GABA(A) receptor alpha6 subunit, whereas ethanol had no effect, in chronically treated granule cell cultures. In addition, concomitant treatment with BDNF and ethanol did not increase the expression of the GABA(A) receptor alpha6 subunit, so the subunit expression alone could not account for the mitigating effect of BDNF. We propose that different mechanisms regulating responsiveness to GABA underlie the effects induced by ethanol and BDNF, with the former influencing the expression of functional GABA(A) receptors and the latter involving the activation of the TrkB receptor and its downstream signaling pathways. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Beroendelära0 (SwePub)303092 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Substance Abuse0 (SwePub)303092 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng |
| 653 | a Alcohol-Induced Disorders | |
| 653 | a Nervous System | |
| 653 | a physiopathology | |
| 653 | a Animals | |
| 653 | a Brain-Derived Neurotrophic Factor | |
| 653 | a metabolism | |
| 653 | a Cells | |
| 653 | a Cultured | |
| 653 | a Central Nervous System Depressants | |
| 653 | a pharmacology | |
| 653 | a Cerebellum | |
| 653 | a physiology | |
| 653 | a Ethanol | |
| 653 | a pharmacology | |
| 653 | a Immunohistochemistry | |
| 653 | a Mice | |
| 653 | a Neurons | |
| 653 | a drug effects | |
| 653 | a metabolism | |
| 653 | a Patch-Clamp Techniques | |
| 653 | a Protein Subunits | |
| 653 | a drug effects | |
| 653 | a metabolism | |
| 653 | a Receptor | |
| 653 | a trkB | |
| 653 | a metabolism | |
| 653 | a Receptors | |
| 653 | a GABA-A | |
| 653 | a drug effects | |
| 653 | a metabolism | |
| 653 | a gamma-Aminobutyric Acid | |
| 653 | a drug effects | |
| 653 | a metabolism | |
| 700 | 1 | a Haythornthwaite, Alison R4 aut |
| 700 | 1 | a Yeh, Pamela W L4 aut |
| 700 | 1 | a Yeh, Hermes H4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för klinisk neurovetenskap, Sektionen för psykiatri4 org |
| 773 | 0 | t Journal of neuroscience researchd : Wileyg 73:5, s. 722-30q 73:5<722-30x 0360-4012x 1097-4547 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/75505 |
| 856 | 4 8 | u https://doi.org/10.1002/jnr.10694 |
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