SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Zhang Hongwen)
 

Search: WFRF:(Zhang Hongwen) > (2023) > Homocysteine accele...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Yang, AnningNingxia Medical University,Hunan University (author)

Homocysteine accelerates hepatocyte autophagy by upregulating TFEB via DNMT3b-mediated DNA hypomethylation

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • 2023-03-31
  • China Science Publishing & Media Ltd.2023
  • 9 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:9131bd3d-afc9-45d3-a988-41797c34ae14
  • https://lup.lub.lu.se/record/9131bd3d-afc9-45d3-a988-41797c34ae14URI
  • https://doi.org/10.3724/abbs.2023060DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Autophagy plays a critical role in the physiology and pathophysiology of hepatocytes. High level of homocysteine (Hcy) promotes autophagy in hepatocytes, but the underlying mechanism is still unknown. Here, we investigate the relationship between Hcy-induced autophagy level and the expression of nuclear transcription factor EB (TFEB). The results show that Hcy-induced autophagy level is mediated by upregulation of TFEB. Silencing of TFEB decreases the level of autophagy-related protein LC3BII/I and increases p62 expression level in hepatocytes after exposure to Hcy. Moreover, the effect of Hcy on the expression of TFEB is regulated by hypomethylation of the TFEB promoter catalyzed by DNA methyltransferase 3b (DNMT3b). In summary, this study shows that Hcy can activate autophagy by inhibiting DNMT3b-mediated DNA methylation and upregulating TFEB expression. These findings provide another new mechanism for Hcy-induced autophagy in hepatocytes.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Zeng, Wen (author)
  • Zhang, HongwenNingxia Medical University (author)
  • Hao, YinjuNingxia Medical University (author)
  • Wang, QingqingNingxia Medical University (author)
  • Sun, YueNingxia Medical University (author)
  • Quan, ShangkunNingxia Medical University (author)
  • Ding, NingNingxia Medical University (author)
  • Yang, XiaolingNingxia Medical University (author)
  • Sun, JianminLund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Ningxia Medical University(Swepub:lu)expk-jsu (author)
  • Zhang, Huiping (author)
  • Liu, BinNingxia Medical University,Hunan University (author)
  • Jiao, YunNingxia Medical University (author)
  • Wu, KaiNingxia Medical University (author)
  • Jiang, YidengNingxia Medical University (author)
  • Ningxia Medical UniversityHunan University (creator_code:org_t)

Related titles

  • In:Acta Biochimica et Biophysica Sinica: China Science Publishing & Media Ltd.55:8, s. 1184-11921672-9145

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view