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WFRF:(Zhang Kexin)
 

Sökning: WFRF:(Zhang Kexin) > Genome architecture...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003150naa a2200445 4500
001oai:gup.ub.gu.se/327479
003SwePub
008240528s2023 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/3274792 URI
0247 a https://doi.org/10.1016/j.xinn.2023.1004642 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Li, Ao4 aut
2451 0a Genome architecture and selective signals compensatorily shape plastic response to a new environment
264 1c 2023
520 a Transcriptional plasticity interacts with natural selection in complex ways and is crucial for the survival of species under rapid climate change. How 3D genome architecture affects transcriptional plasticity and its interaction with genetic adaptation are unclear. We transplanted estuarine oysters to a new environment and found that genes located in active chromatin regions exhibited greater transcriptional plasticity, and changes in these regions were negatively correlated with selective signals. This indicates a trade-off be- tween 3D active regions and selective signals in shaping plastic responses to a new environment. Specifically, a mutation, lincRNA, and changes in the accessibility of a distal enhancer potentially affect its interaction with the ManIIa gene, which regulates the muscle function and survival of oysters. Our findings reveal that 3D genome architecture compensates for the role of genetic adaptation in environmental response to new environments and provide insights into synergetic genetic and epigenetic interactions critical for fitness-related trait and survival in a model marine species.
650 7a NATURVETENSKAPx Biologix Bioinformatik och systembiologi0 (SwePub)106102 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Bioinformatics and Systems Biology0 (SwePub)106102 hsv//eng
650 7a NATURVETENSKAPx Biologix Cellbiologi0 (SwePub)106042 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Cell Biology0 (SwePub)106042 hsv//eng
650 7a NATURVETENSKAPx Biologix Genetik0 (SwePub)106092 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Genetics0 (SwePub)106092 hsv//eng
653 a Oyster; Chromatin structure; Local adaptation; Plasticity
7001 a Zhao, Mingjie4 aut
7001 a Wang, Chaogang4 aut
7001 a Zhang, Kexin4 aut
7001 a Zhang, Xu4 aut
7001 a De Wit, Pierre,d 1978u Gothenburg University,Göteborgs universitet,Institutionen för marina vetenskaper, Tjärnö marinlaboratoriet,Department of marine sciences, Tjärnö Marine Laboratory4 aut0 (Swepub:gu)xdewpi
7001 a Wang, Wei4 aut
7001 a Gao, Juntao4 aut
7001 a Guo, Ximing4 aut
7001 a Zhang, Guofan4 aut
7001 a Li, Li4 aut
7102 a Göteborgs universitetb Institutionen för marina vetenskaper, Tjärnö marinlaboratoriet4 org
7730 t The Innovationg 4:4q 4:4x 2666-6758
8564 8u https://gup.ub.gu.se/publication/327479
8564 8u https://doi.org/10.1016/j.xinn.2023.100464

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