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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007442naa a2200961 4500
001oai:lup.lub.lu.se:6137e451-948a-47ba-b6b2-25e23ea7d29c
003SwePub
008231112s2022 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/6137e451-948a-47ba-b6b2-25e23ea7d29c2 URI
0247 a https://doi.org/10.1016/S2214-109X(21)00485-X2 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Pisani, Luigiu Mahidol University,Doctors with Africa CUAMM,Miulli General Hospital,Academic Medical Center of University of Amsterdam (AMC)4 aut
2451 0a Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome : a pooled analysis of four observational studies
264 1c 2022
520 a Background: Geoeconomic variations in epidemiology, the practice of ventilation, and outcome in invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient data of four large observational studies. Methods: In this pooled analysis we harmonised individual patient data from the ERICC, LUNG SAFE, PRoVENT, and PRoVENT-iMiC prospective observational studies, which were conducted from June, 2011, to December, 2018, in 534 ICUs in 54 countries. We used the 2016 World Bank classification to define two geoeconomic regions: middle-income countries (MICs) and high-income countries (HICs). ARDS was defined according to the Berlin criteria. Descriptive statistics were used to compare patients in MICs versus HICs. The primary outcome was the use of low tidal volume ventilation (LTVV) for the first 3 days of mechanical ventilation. Secondary outcomes were key ventilation parameters (tidal volume size, positive end-expiratory pressure, fraction of inspired oxygen, peak pressure, plateau pressure, driving pressure, and respiratory rate), patient characteristics, the risk for and actual development of acute respiratory distress syndrome after the first day of ventilation, duration of ventilation, ICU length of stay, and ICU mortality. Findings: Of the 7608 patients included in the original studies, this analysis included 3852 patients without ARDS, of whom 2345 were from MICs and 1507 were from HICs. Patients in MICs were younger, shorter and with a slightly lower body-mass index, more often had diabetes and active cancer, but less often chronic obstructive pulmonary disease and heart failure than patients from HICs. Sequential organ failure assessment scores were similar in MICs and HICs. Use of LTVV in MICs and HICs was comparable (42·4% vs 44·2%; absolute difference –1·69 [–9·58 to 6·11] p=0·67; data available in 3174 [82%] of 3852 patients). The median applied positive end expiratory pressure was lower in MICs than in HICs (5 [IQR 5–8] vs 6 [5–8] cm H2O; p=0·0011). ICU mortality was higher in MICs than in HICs (30·5% vs 19·9%; p=0·0004; adjusted effect 16·41% [95% CI 9·52–23·52]; p<0·0001) and was inversely associated with gross domestic product (adjusted odds ratio for a US$10 000 increase per capita 0·80 [95% CI 0·75–0·86]; p<0·0001). Interpretation: Despite similar disease severity and ventilation management, ICU mortality in patients without ARDS is higher in MICs than in HICs, with a strong association with country-level economic status. Funding: No funding.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Anestesi och intensivvård0 (SwePub)302012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Anesthesiology and Intensive Care0 (SwePub)302012 hsv//eng
7001 a Algera, Anna Gekeu Academic Medical Center of University of Amsterdam (AMC)4 aut
7001 a Neto, Ary Serpau Monash University,Austin Hospital,Melbourne Medical School,Australian and New Zealand Intensive Care Research Centre,Albert Einstein Israelite Hospital4 aut
7001 a Azevedo, Luciano Cesaru University of São Paulo4 aut
7001 a Pham, Tàiu Li Ka Shing Knowledge Institute,University of Toronto4 aut
7001 a Paulus, Frederiqueu Academic Medical Center of University of Amsterdam (AMC)4 aut
7001 a de Abreu, Marcelo Gamau University Clinic Carl Gustav Carus at the TU Dresden4 aut
7001 a Pelosi, Paolou University of Genoa,Ospedale Policlinico San Martino4 aut
7001 a Dondorp, Arjen M.u Mahidol University,University of Oxford4 aut
7001 a Bellani, Giacomou University of Milano-Bicocca4 aut
7001 a Laffey, John G.u Galway University Hospital4 aut
7001 a Schultz, Marcus J.u Mahidol University,Academic Medical Center of University of Amsterdam (AMC)4 aut
7001 a Martinez, Amadeu4 aut
7001 a Leal, Livia4 aut
7001 a Jorge Pereira, Antonio4 aut
7001 a de Oliveira Maia, Marcelo4 aut
7001 a Neto, Josè Aires4 aut
7001 a Piras, Claudio4 aut
7001 a Caser, Eliana Bernadete4 aut
7001 a Moreira, Cora Lavigne4 aut
7001 a Braga Gusman, Pablo4 aut
7001 a Dalcomune, Dyanne Moysés4 aut
7001 a Ribeiro de Carvalho, Alexandre Guilherme4 aut
7001 a Gondim, Louise Aline Romão4 aut
7001 a Castelo Branco Reis, Lívia Mariane4 aut
7001 a da Cunha Ribeiro, Daniel4 aut
7001 a de Assis Simões, Leonardo4 aut
7001 a Campos, Rafaela Siqueira4 aut
7001 a Fernandez Versiani dos Anjos, José Carlos4 aut
7001 a Bruzzi Carvalho, Frederico4 aut
7001 a Alves, Rossine Ambrosio4 aut
7001 a Nunes, Lilian Batista4 aut
7001 a Réa-Neto, Álvaro4 aut
7001 a de Oliveira, Mirella Cristine4 aut
7001 a Tannous, Luana4 aut
7001 a Cardoso Gomes, Brenno4 aut
7001 a Rodriguez, Fernando Borges4 aut
7001 a Abelha, Priscila4 aut
7001 a Larsson, Anders4 aut
7001 a Liu, Haitao4 aut
7001 a Wang, Wei4 aut
7001 a Zhang, Fan4 aut
7001 a Liu, Jian4 aut
7001 a Li, Bin4 aut
7001 a Liu, Jing L.4 aut
7001 a Li, Yuan Y.4 aut
7001 a Oliveira, Bruno S.4 aut
7001 a Larsson, Niklas4 aut
7001 a Smith, Roger4 aut
7001 a Kander, Thomasu Lund University,Lunds universitet,Klinisk forskning inom anestesi och intensivvårdsmedicin,Forskargrupper vid Lunds universitet,Clinical Research in Anaesthesia and Intensive Care Medicine,Lund University Research Groups4 cre0 (Swepub:lu)med-tkn
7102 a Mahidol Universityb Doctors with Africa CUAMM4 org
7102 a PRoVENT-iMiC study investigators
7102 a ERICC study investigators
7102 a LUNG SAFE study investigators
7102 a PRoVENT study investigators
7102 a PRoVENT-iMiC study investigators
7102 a ERICC study investigators
7102 a LUNG SAFE study investigators
7102 a PRoVENT study investigators
7730 t The Lancet Global Healthg 10:2, s. 227-235q 10:2<227-235x 2214-109X
8564 u http://dx.doi.org/10.1016/S2214-109X(21)00485-Xx freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/6137e451-948a-47ba-b6b2-25e23ea7d29c
8564 8u https://doi.org/10.1016/S2214-109X(21)00485-X

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