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Sökning: WFRF:(van der Meer Rieneke) > (2023) > Genetic variants as...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003840naa a2200421 4500
001oai:lup.lub.lu.se:95dd2187-b78c-4348-9623-311ac935e33e
003SwePub
008231110s2023 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/95dd2187-b78c-4348-9623-311ac935e33e2 URI
0247 a https://doi.org/10.1111/obr.136262 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a for2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a van der Meer, Rienekeu Academic Medical Center of University of Amsterdam (AMC)4 aut
2451 0a Genetic variants associated with weight loss and metabolic outcomes after bariatric surgery : A systematic review
264 1c 2023
520 a The extent to which genetic variations contribute to interindividual differences in weight loss and metabolic outcomes after bariatric surgery is unknown. Identifying genetic variants that impact surgery outcomes may contribute to clinical decision making. This review evaluates current evidence addressing the association of genetic variants with weight loss and changes in metabolic parameters after bariatric surgery. A search was conducted using Medline, Embase, Scopus, Web of Science, and Cochrane Library. Fifty-two eligible studies were identified. Single nucleotide polymorphisms (SNPs) at ADIPOQ (rs226729, rs1501299, rs3774261, and rs17300539) showed a positive association with postoperative change in measures of glucose homeostasis and lipid profiles (n = 4), but not with weight loss after surgery (n = 6). SNPs at FTO (rs11075986, rs16952482, rs8050136, rs9939609, rs9930506, and rs16945088) (n = 10) and MC4R (rs11152213, rs476828, rs2229616, rs9947255, rs17773430, rs5282087, and rs17782313) (n = 9) were inconsistently associated with weight loss and metabolic improvement. Four studies examining the UCP2 SNP rs660339 reported associations with postsurgical weight loss. In summary, there is limited evidence supporting a role for specific genetic variants in surgical outcomes after bariatric surgery. Most studies have adopted a candidate gene approach, limiting the scope for discovery, suggesting that the absence of compelling evidence is not evidence of absence.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
653 a bariatric surgery
653 a genetic variants
653 a SNPs
653 a surgery outcomes
7001 a Mohamed, Siham A.u Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)si5462ab
7001 a Monpellier, Valerie M.u Obesity Clinic Hoogeveen4 aut
7001 a Liem, Ronald S.L.u Obesity Clinic Hoogeveen4 aut
7001 a Hazebroek, Eric J.u Rijnstate Hospital4 aut
7001 a Franks, Paul W.u Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-plf
7001 a Frayling, Timothy M.u University of Exeter4 aut
7001 a Janssen, Ignace M.C.4 aut
7001 a Serlie, Mireille J.u Yale University,Academic Medical Center of University of Amsterdam (AMC)4 aut
7102 a Academic Medical Center of University of Amsterdam (AMC)b Genetisk och molekylär epidemiologi4 org
7730 t Obesity Reviewsg 24:12q 24:12x 1467-7881
8564 u http://dx.doi.org/10.1111/obr.13626x freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/95dd2187-b78c-4348-9623-311ac935e33e
8564 8u https://doi.org/10.1111/obr.13626

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