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Sökning: WFRF:(von Ehrenstein Ondine S.) > (2021) > A longitudinal stud...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004961naa a2200493 4500
001oai:DiVA.org:uu-440155
003SwePub
008210426s2021 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:146029703
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4401552 URI
0247 a https://doi.org/10.1016/j.envpol.2020.1163332 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1460297032 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Akhtar, Evanau Icddr B, Infect Dis Div, Dhaka 1212, Bangladesh4 aut
2451 0a A longitudinal study of rural Bangladeshi children with long-term arsenic and cadmium exposures and biomarkers of cardiometabolic diseases
264 1b Elsevier,c 2021
338 a print2 rdacarrier
520 a There is growing interest in understanding the contribution of environmental toxicant exposure in early life to development of cardiometabolic diseases (CMD) in adulthood. We aimed to assess associations of early life exposure to arsenic and cadmium with biomarkers of CMD in children in rural Bangladesh. From a longitudinal mother-child cohort in Matlab, Bangladesh, we followed up 540 pairs. Exposure to arsenic (U–As) and cadmium (U–Cd) was assessed by concentrations in urine from mothers at gestational week 8 (GW8) and children at ages 4.5 and 9 years. Blood pressure and anthropometric indices were measured at 4.5 and 9 years. Metabolic markers (lipids, glucose, hemoglobin A1c, adipokines, estimated glomerular filtration rate (eGFR) were determined in plasma/blood of 9 years old children. In linear regression models, adjusted for child sex, age, height-for-age z score (HAZ), BMI-for-age z score (BAZ), socioeconomic status (SES) and maternal education, each doubling of maternal and early childhood U–Cd was associated with 0.73 and 0.82 mmHg increase in systolic blood pressure (SBP) respectively. Both early and concurrent childhood U–Cd was associated with diastolic (D)BP (β = 0.80 at 4.5 years; β = 0.75 at 9 years). Each doubling of U–Cd at 9 years was associated with decrements of 4.98 mg/dL of total cholesterol (TC), 1.75 mg/dL high-density lipoprotein (HDL), 3.85 mg/dL low-density lipoprotein (LDL), 0.43 mg/dL glucose and 4.29 units eGFR. Each doubling of maternal U–Cd was associated with a decrement of 1.23 mg/dL HDL. Both maternal and childhood U–As were associated with decrement in TC and HDL. Multiple comparisons were checked with family-wise error rate Bonferroni-type-approach. The negative associations of arsenic and cadmium with biomarkers of CMD in preadolescent children indicated influence of both metal(loid)s on fat and carbohydrate metabolism, while cadmium additionally influenced kidney function and BP. Thus, fewer outcomes were associated with U–As compared to U–Cd at preadolescence.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng
653 a Arsenic
653 a Cadmium
653 a Prenatal and childhood exposure
653 a Cardiometabolic biomarkers
7001 a Roy, Anjan Kumaru Icddr B, Infect Dis Div, Dhaka 1212, Bangladesh4 aut
7001 a Haq, Md Ahsanulu Icddr B, Infect Dis Div, Dhaka 1212, Bangladesh4 aut
7001 a von Ehrenstein, Ondine S.u Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Community Hlth Sci & Epidemiol, Los Angeles, CA 90024 USA4 aut
7001 a Ahmed, Sultanu Icddr B, Infect Dis Div, Dhaka 1212, Bangladesh4 aut
7001 a Vahter, Marieu Karolinska Institutet4 aut
7001 a Ekström, Eva-Charlotte,d 1956-u Uppsala universitet,Internationell barnhälsa och nutrition4 aut0 (Swepub:uu)loeks254
7001 a Kippler, Mariau Karolinska Institutet4 aut
7001 a Wagatsuma, Yukikou Univ Tsukuba, Fac Med, Dept Clin Trial & Clin Epidemiol, Tsukuba, Ibaraki, Japan4 aut
7001 a Raqib, Rubhanau Icddr B, Infect Dis Div, Dhaka 1212, Bangladesh4 aut
7102 a Icddr B, Infect Dis Div, Dhaka 1212, Bangladeshb Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Community Hlth Sci & Epidemiol, Los Angeles, CA 90024 USA4 org
7730 t Environmental Pollutiond : Elsevierg 271q 271x 0269-7491x 1873-6424
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-440155
8564 8u https://doi.org/10.1016/j.envpol.2020.116333
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:146029703

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