Sökning: onr:"swepub:oai:DiVA.org:kth-185568" > Squalene hopene cyc...
Fältnamn | Indikatorer | Metadata |
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000 | 02321naa a2200361 4500 | |
001 | oai:DiVA.org:kth-185568 | |
003 | SwePub | |
008 | 160422s2013 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-1855682 URI |
024 | 7 | a https://doi.org/10.1016/j.cbpa.2013.01.0162 DOI |
040 | a (SwePub)kth | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Hammer, Stephan C.4 aut |
245 | 1 0 | a Squalene hopene cyclases :b highly promiscuous and evolvable catalysts for stereoselective CC and CX bond formation |
264 | 1 | b Elsevier,c 2013 |
338 | a print2 rdacarrier | |
500 | a QC 20160429 | |
520 | a A review. We review here how the inherent promiscuous nature, as well as the evolvability of terpene cyclase enzymes enables new applications in chem. We mainly focus on squalene hopene cyclases, class II triterpene synthases that use a proton-initiated cationic polycyclization cascade to form carbopolycyclic products. We highlight recent findings to demonstrate that these enzymes are capable of activating different functionalities other than the traditional terminal isoprene CC-group as well as being compatible with a wide range of nucleophiles beyond the 'ene-functionality'. Thus, squalene hopene cyclases demonstrate a great potential to be used as a toolbox for general Bronsted acid catalysis. | |
650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
653 | a review squalene hopene cyclase promiscuous evolvable catalyst stereoselectivity | |
700 | 1 | a Syren, Per-Olofu Universitaet Stuttgart, Germany4 aut0 (Swepub:kth)u1ewlo1g |
700 | 1 | a Seitz, Miriam4 aut |
700 | 1 | a Nestl, Bettina M.4 aut |
700 | 1 | a Hauer, Bernhard4 aut |
710 | 2 | a Universitaet Stuttgart, Germany4 org |
773 | 0 | t Current opinion in chemical biologyd : Elsevierg 17:2, s. 293-300q 17:2<293-300x 1367-5931x 1879-0402 |
856 | 4 | u http://www.sciencedirect.com/science/article/pii/S1367593113000215 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-185568 |
856 | 4 8 | u https://doi.org/10.1016/j.cbpa.2013.01.016 |
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