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Catalytic Self-Scre...
Catalytic Self-Screening of Cholinesterase Substrates from a Dynamic Combinatorial Thioester Library
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- Larsson, Rikard (författare)
- KTH,Kemi
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- Pei, Zhichao (författare)
- KTH,Kemi
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- Ramström, Olof (författare)
- KTH,Kemi
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(creator_code:org_t)
- Wiley, 2004
- 2004
- Engelska.
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Ingår i: Angewandte Chemie International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 43:28, s. 3716-3718
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Simply the best: Dynamic combinatorial chemistry coupled to enzyme catalysis was used to identify enzyme substrates in a library constructed from a series of thioesters and thiols by transesterification. The library was directly coupled to the catalytic action of acetylcholinesterase, which selectively hydrolyzed the best substrate candidates (see schematic representation). The process allowed rapid identification of discrete substrates.
Ämnesord
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Nyckelord
- combinatorial chemistry; enzyme catalysis hydrolysis; proteomics; transesterification
- Organic chemistry
- Organisk kemi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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