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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007058naa a2200733 4500
001oai:DiVA.org:liu-90675
003SwePub
008130403s2013 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:ce7cb2a5-9771-4ed3-8ad6-d2c0fc949efb
009oai:DiVA.org:uu-222288
009oai:prod.swepub.kib.ki.se:126294072
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-906752 URI
0247 a https://doi.org/10.1111/j.1399-5448.2012.00916.x2 DOI
0247 a https://lup.lub.lu.se/record/31241792 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2222882 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1262940722 URI
040 a (SwePub)liud (SwePub)lud (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Andersson, Cu Lund University, Sweden,Barnendokrinologisk forskning/Gustafsson4 aut
2451 0a Triple specificity of ZnT8 autoantibodies in relation to HLA and other islet autoantibodies in childhood and adolescent type 1 diabetes
264 c 2012-09-10
264 1b Wiley-Blackwell,c 2013
338 a print2 rdacarrier
500 a Funding Agencies|Swedish Research Council|14064|Swedish Child Diabetes Foundation||Swedish Diabetes Association||National Institutes of Health|DK26190|UMAS Fund||Knut and Alice Wallenberg Foundation||Skane County Council for Research and Development||
500 a Co-author: Ingemar Swenne, Uppsala universitet, institutionen för kvinnors och barns hälsa, forskargrupp Barnendokrinologisk forskning, ingår i members of the BDD Study group.
520 a Andersson C, Vaziri-Sani F, Delli AJ, Lindblad B, Carlsson A, Forsander G, Ludvigsson J, Marcus C, Samuelsson U, Ivarsson SA, Lernmark A, Elding Larsson H, the BDD Study group. Triple specificity of ZnT8 autoantibodies in relation to HLA and other islet autoantibodies in childhood and adolescent type 1 diabetes. Pediatric Diabetes 2013: 14: 97-105. Objective To establish the diagnostic sensitivity of and the relationships between autoantibodies to all three Zinc transporter 8 (Zinc transporter 8 autoantibody to either one, two, or all three amino acid variants at position 325, ZnT8A) variants to human leukocyte antigen (HLA)-DQ and to autoantibodies to glutamic acid decarboxylase (GADA), insulinoma-associated protein 2 (IA-2A), and insulin (IAA). Methods We analyzed 3165 patients with type 1 diabetes (T1D) in the Better Diabetes Diagnosis study for HLA-DQ genotypes and all six autoantibodies (ZnT8RA, arginine 325 Zinc transporter 8 autoantibody; ZnT8WA, tryptophan 325 Zinc transporter 8 autoantibody; ZnT8QA, glutamine 325 Zinc transporter 8 autoantibody; GADA, IA-2A, and IAA). Results ZnT8A was found in 65% of the patients and as many as 108 of 3165 (3.4%) had 13 ZnT8A alone. None had ZnT8QA alone. Together with GADA (56%), IA-2A (73%), and IAA (33%), 93% of the T1D patients were autoantibody positive. All three ZnT8A were less frequent in children below 2 yr of age (pandlt;0.0001). All three ZnT8A were associated with DQA1-B1*X-0604 (DQ6.4) and DQA1-B1*03-0302 (DQ8). ZnT8WA and ZnT8QA were negatively associated with DQA1-B1*05-02 (DQ2). Conclusions Analysis of ZnT8A increased the diagnostic sensitivity of islet autoantibodies for T1D as only 7% remained islet autoantibody negative. The association between DQ6.4 and all three ZnT8A may be related to ZnT8 antigen presentation by the DQ6.4 heterodimer.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng
653 a diabetes mellitus
653 a GAD65 autoantibodies
653 a HLA genotype
653 a IA-2 autoantibodies
653 a insulin autoantibodies
653 a type 1 diabetes
653 a Zinc transporter
653 a ZnT8
653 a MEDICINE
653 a MEDICIN
7001 a Vaziri Sani, Faribau Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital,Lund University, Sweden4 aut0 (Swepub:lu)fa3255va
7001 a Delli, A J.u Lund University, Sweden4 aut
7001 a Lindblad, Bu Queen Silvia Childrens Hospital, Sweden,Queen Silvia Children’s Hospital4 aut
7001 a Carlsson, Annelieu Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden4 aut0 (Swepub:lu)med-acs
7001 a Forsander, Gu Queen Silvia Childrens Hospital, Sweden4 aut
7001 a Ludvigsson, Johnnyu Östergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping4 aut0 (Swepub:liu)johlu29
7001 a Marcus, Cu Karolinska Institutet,Karolinska Institute, Sweden4 aut
7001 a Samuelsson, Ulfu Östergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping,Linköping University Hospital4 aut0 (Swepub:liu)ulfsa43
7001 a Ivarsson, S A.u Lund University, Sweden4 aut
7001 a Lernmark, Åkeu Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital,Lund University, Sweden4 aut0 (Swepub:lu)endo-ale
7001 a Elding Larsson, Hu Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Skåne University Hospital,Lund University, Sweden4 aut0 (Swepub:lu)pedi-hla
7001 a Swenne, Ingemaru Uppsala universitet,Pediatrik4 ctb0 (Swepub:uu)ingeswen
7102 a Lund University, Swedenb Barnendokrinologisk forskning/Gustafsson4 org
7102 a The BDD Study Group
7730 t Pediatric Diabetesd : Wiley-Blackwellg 14:2, s. 97-105q 14:2<97-105x 1399-543Xx 1399-5448
8564 u http://dx.doi.org/10.1111/j.1399-5448.2012.00916.xy FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-90675
8564 8u https://doi.org/10.1111/j.1399-5448.2012.00916.x
8564 8u https://lup.lub.lu.se/record/3124179
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-222288
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:126294072

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