Search: onr:"swepub:oai:DiVA.org:oru-25828" > A miRNA expression ...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 04405naa a2200469 4500 | |
001 | oai:DiVA.org:oru-25828 | |
003 | SwePub | |
008 | 120913s2011 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:his-5544 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-258282 URI |
024 | 7 | a https://doi.org/10.1186/1475-2867-11-142 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-55442 URI |
040 | a (SwePub)orud (SwePub)his | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Carlsson, Jessica,d 1984-u Högskolan i Skövde,Örebro universitet,Hälsoakademin,Tumörbiologi, Bioinformatik,Institutionen för vård och natur,Forskningscentrum för Systembiologi4 aut0 (Swepub:his)care |
245 | 1 0 | a A miRNA expression signature that separates between normal and malignant prostate tissues |
264 | c 2011-05-27 | |
264 | 1 | b BioMed Central (BMC),c 2011 |
338 | a print2 rdacarrier | |
520 | a BackgroundMicroRNAs (miRNAs) constitute a class of small non-coding RNAs that post-transcriptionally regulate genes involved in several key biological processes and thus are involved in various diseases, including cancer. In this study we aimed to identify a miRNA expression signature that could be used to separate between normal and malignant prostate tissues.ResultsNine miRNAs were found to be differentially expressed (p <0.00001). With the exception of two samples, this expression signature could be used to separate between the normal and malignant tissues. A cross-validation procedure confirmed the generality of this expression signature. We also identified 16 miRNAs that possibly could be used as a complement to current methods for grading of prostate tumor tissues.ConclusionsWe found an expression signature based on nine differentially expressed miRNAs that with high accuracy (85%) could classify the normal and malignant prostate tissues in patients from the Swedish Watchful Waiting cohort. The results show that there are significant differences in miRNA expression between normal and malignant prostate tissue, indicating that these small RNA molecules might be important in the biogenesis of prostate cancer and potentially useful for clinical diagnosis of the disease. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a Medicine | |
653 | a Medicin | |
653 | a Medical sciences | |
700 | 1 | a Davidsson, Sabinau Örebro universitet,Hälsoakademin,Orebro Univ Hosp, Dept Urol, Orebro, Sweden / Univ Orebro, Sch Hlth & Med Sci, Orebro, Sweden4 aut0 (Swepub:oru)sdn |
700 | 1 | a Helenius, Giselau Örebro universitet,Institutionen för läkarutbildning,Örebro University Hospital, Örebro, Sweden,Orebro Univ Hosp, Dept Lab Med, Orebro, Sweden4 aut0 (Swepub:oru)ghs |
700 | 1 | a Karlsson, Mats,d 1960-u Örebro universitet,Institutionen för läkarutbildning,Örebro University Hospital, Örebro, Sweden,Orebro Univ Hosp, Dept Lab Med, Orebro, Sweden4 aut0 (Swepub:oru)mskn |
700 | 1 | a Lubovac, Zelminau Högskolan i Skövde,Institutionen för vård och natur,Forskningscentrum för Systembiologi4 aut0 (Swepub:his)lubz |
700 | 1 | a Andrén, Oveu Örebro universitet,Institutionen för läkarutbildning,Örebro University Hospital, Örebro, Sweden,Orebro Univ Hosp, Dept Urol, Orebro, Sweden4 aut0 (Swepub:oru)oan |
700 | 1 | a Olsson, Björnu Högskolan i Skövde,Institutionen för vård och natur,Forskningscentrum för Systembiologi4 aut0 (Swepub:his)olsb |
700 | 1 | a Klinga-Levan, Karinu Högskolan i Skövde,Institutionen för vård och natur,Forskningscentrum för Systembiologi4 aut0 (Swepub:his)klik |
710 | 2 | a Örebro universitetb Hälsoakademin4 org |
773 | 0 | t Cancer Cell Internationald : BioMed Central (BMC)g :11, s. 14-q :11<14-x 1475-2867 |
856 | 4 | u https://cancerci.biomedcentral.com/track/pdf/10.1186/1475-2867-11-14 |
856 | 4 | u https://his.diva-portal.org/smash/get/diva2:508734/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-25828 |
856 | 4 8 | u https://doi.org/10.1186/1475-2867-11-14 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-5544 |
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