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Sökning: onr:"swepub:oai:DiVA.org:umu-122146" > Birth weight and ri...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004556naa a2200565 4500
001oai:DiVA.org:umu-122146
003SwePub
008160615s2004 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:110584464
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1221462 URI
0247 a https://doi.org/10.1093/jnci/djh2872 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1105844642 URI
040 a (SwePub)umud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Hjalgrim, Lisa Lyngsie4 aut
2451 0a Birth weight and risk for childhood leukemia in Denmark, Sweden, Norway, and Iceland
264 c 2004-10-19
264 1a Cary :b Oxford University Press,c 2004
338 a print2 rdacarrier
520 a Background: Compelling evidence suggests that childhood leukemia often originates in utero. Birth weight is one of the few pregnancy-related risk factors that has been associated with leukemia risk, but the association has remained poorly characterized. We conducted a population-based case-control stud-v in Denmark, Sweden, Norway, and Iceland to investigate the association between birth weight (and other birth characteristics) and the risk of childhood leukemia.Methods: Overall, 1905 children (aged 0-14 years) with acute lymphoblastic leukemia (ALL) and 299 children with acute myeloid leukemia (AML) diagnosed between January 1, 1984, and December 31, 1999, were identified in the Nordic Society of Paediatric Haematology and Oncology acute leukemia database. Each case patient was matched to five population control subjects (n = 1.0 745) on nationality, age, and sex. All live-born siblings of case patients (n = 3812) and control subjects (n = 17 937) were also identified in population registers. Information on birth weight and gestational age at birth was ascertained from the national Medical Birth Registers. The association between various birth characteristics and leukemia risk was assessed by conditional logistic regression. All statistical tests were two-sided.Results: Risk of ALL overall was statistically significantly associated with birth weight (odds ratio [OR] = 1.26 per 1-kg increase in birth weight, 95% confidence interval [CI] = 1.13 to 1.41). The association was similar for B- and T-lineage ALL and across all diagnostic ages (0-14 years). However, children with ALL did not weigh more at birth than their siblings. Statistically significantly reduced risks of B-precursor ALL were observed with increasing position in the birth order (OR = 0.90 per position increase, 95% CI = 0.84 to 0.96) and increasing gestational age (OR = 0.87 per 2-week increase in gestational age, 95% CI = 0.81 to 0.94). Risk of AML did not vary monotonically with birth weight, and low birth weight (<1500 g [i.e., 3.3 pounds]) was associated with the highest risk.Conclusion: Our results are compatible with the hypothesis that a high birth weight is associated with an increased risk of ALL.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a acute lymphoblastic leukemia
653 a maternal reproductive history
653 a acute lymphocytic leukemia
653 a childrens cancer group
653 a prenatal origin
653 a epidemiologic research
653 a Nordic countries
653 a infant leukemia
653 a Downs syndrome
653 a Wilms tumor
7001 a Rostgaard, Klaus4 aut
7001 a Hjalgrim, Henrik4 aut
7001 a Westergaard, Tine4 aut
7001 a Thomassen, Harald4 aut
7001 a Forestier, Eriku Umeå universitet,Pediatrik4 aut0 (Swepub:umu)erfo0007
7001 a Gustafsson, Göranu Karolinska Institutet4 aut
7001 a Kristinsson, Jon4 aut
7001 a Melbye, Mads4 aut
7001 a Schmiegelow, Kjeld4 aut
7102 a Umeå universitetb Pediatrik4 org
7730 t Journal of the National Cancer Instituted Cary : Oxford University Pressg 96:20, s. 1549-1556q 96:20<1549-1556x 0027-8874x 1460-2105
8564 u https://academic.oup.com/jnci/article-pdf/96/20/1549/7685820/djh287.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-122146
8564 8u https://doi.org/10.1093/jnci/djh287
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:110584464

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