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Sökning: onr:"swepub:oai:DiVA.org:umu-144398" > Role of enhanced re...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003931naa a2200589 4500
001oai:DiVA.org:umu-144398
003SwePub
008180213s2018 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1443982 URI
0247 a https://doi.org/10.1073/pnas.17132841152 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Baggen, Jim4 aut
2451 0a Role of enhanced receptor engagement in the evolution of a pandemic acute hemorrhagic conjunctivitis virus
264 c 2017-12-28
264 1b National Academy of Sciences,c 2018
338 a print2 rdacarrier
520 a Acute hemorrhagic conjunctivitis (AHC) is a painful, contagious eye disease, with millions of cases in the last decades. Coxsackievirus A24 (CV-A24) was not originally associated with human disease, but in 1970 a pathogenic "variant" (CV-A24v) emerged, which is now the main cause of AHC. Initially, this variant circulated only in Southeast Asia, but it later spread worldwide, accounting for numerous AHC outbreaks and two pandemics. While both CV-A24 variant and nonvariant strains still circulate in humans, only variant strains cause AHC for reasons that are yet unknown. Since receptors are important determinants of viral tropism, we set out to map the CV-A24 receptor repertoire and establish whether changes in receptor preference have led to the increased pathogenicity and rapid spread of CV-A24v. Here, we identify ICAM-1 as an essential receptor for both AHC-causing and non-AHC strains. We provide a high-resolution cryo-EM structure of a virus-ICAM-1 complex, which revealed critical ICAM-1-binding residues. These data could help identify a possible conserved mode of receptor engagement among ICAM-1-binding enteroviruses and rhinoviruses. Moreover, we identify a single capsid substitution that has been adopted by all pandemic CV-A24v strains and we reveal that this adaptation enhances the capacity of CV-A24v to bind sialic acid. Our data elucidate the CV-A24v receptor repertoire and point to a role of enhanced receptor engagement in the adaptation to the eye, possibly enabling pandemic spread.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng
653 a conjunctivitis
653 a coxsackievirus A24v
653 a receptor
653 a ICAM-1
653 a sialic acid
7001 a Hurdiss, Daniel L.4 aut
7001 a Zocher, Georg4 aut
7001 a Mistry, Niteshu Umeå universitet,Virologi4 aut0 (Swepub:umu)mini0002
7001 a Roberts, Richard W.4 aut
7001 a Slager, Jasper J.4 aut
7001 a Guo, Hongbo4 aut
7001 a van Vliet, Arno L. W.4 aut
7001 a Wahedi, Maryam4 aut
7001 a Benschop, Kimberley4 aut
7001 a Duizer, Erwin4 aut
7001 a de Haan, Cornelis A. M.4 aut
7001 a de Vries, Erik4 aut
7001 a Casasnovas, José M.4 aut
7001 a de Groot, Raoul J.4 aut
7001 a Arnberg, Niklasu Umeå universitet,Virologi4 aut0 (Swepub:umu)niar0001
7001 a Stehle, Thilo4 aut
7001 a Ranson, Neil A.4 aut
7001 a Thibaut, Hendrik Jan4 aut
7001 a van Kuppeveld, Frank J. M.4 aut
7102 a Umeå universitetb Virologi4 org
7730 t Proceedings of the National Academy of Sciences of the United States of Americad : National Academy of Sciencesg 115:2, s. 397-402q 115:2<397-402x 0027-8424x 1091-6490
8564 u https://www.pnas.org/content/pnas/115/2/397.full.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-144398
8564 8u https://doi.org/10.1073/pnas.1713284115

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