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Sökning: onr:"swepub:oai:DiVA.org:umu-214279" > Biomarker-based pre...

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FältnamnIndikatorerMetadata
00010962naa a2200745 4500
001oai:DiVA.org:umu-214279
003SwePub
008230911s2023 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2142792 URI
0247 a https://doi.org/10.1093/eurjpc/zwad1222 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Haller, Paul M.u Department for Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Luebeck, Martinistrasse 52, Hamburg, Germany4 aut
2451 0a Biomarker-based prediction of fatal and non-fatal cardiovascular outcomes in individuals with diabetes mellitus
264 1c 2023
338 a print2 rdacarrier
520 a AIMS: The role of biomarkers in predicting cardiovascular outcomes in high-risk individuals is not well established. We aimed to investigate benefits of adding biomarkers to cardiovascular risk assessment in individuals with and without diabetes. 'METHODS AND RESULTS: We used individual-level data of 95 292 individuals of the European population harmonized in the Biomarker for Cardiovascular Risk Assessment across Europe consortium and investigated the prognostic ability of high-sensitivity cardiac troponin I (hs-cTnI), N-terminal prohormone of brain natriuretic peptide (NT-proBNP), and high-sensitivity C-reactive protein (hs-CRP). Cox-regression models were used to determine adjusted hazard ratios of diabetes and log-transformed biomarkers for fatal and non-fatal cardiovascular events. Models were compared using the likelihood ratio test. Stratification by specific biomarker cut-offs was performed for crude time-to-event analysis using Kaplan-Meier plots. Overall, 6090 (6.4%) individuals had diabetes at baseline, median follow-up was 9.9 years. Adjusting for classical risk factors and biomarkers, diabetes [HR 2.11 (95% CI 1.92, 2.32)], and all biomarkers (HR per interquartile range hs-cTnI 1.08 [95% CI 1.04, 1.12]; NT-proBNP 1.44 [95% CI 1.37, 1.53]; hs-CRP 1.27 [95% CI 1.21, 1.33]) were independently associated with cardiovascular events. Specific cut-offs for each biomarker identified a high-risk group of individuals with diabetes losing a median of 15.5 years of life compared to diabetics without elevated biomarkers. Addition of biomarkers to the Cox-model significantly improved the prediction of outcomes (likelihood ratio test for nested models P < 0.001), accompanied by an increase in the c-index (increase to 0.81).CONCLUSION: Biomarkers improve cardiovascular risk prediction in individuals with and without diabetes and facilitate the identification of individuals with diabetes at highest risk for cardiovascular events.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653 a Biomarkers
653 a Cardiovascular events
653 a Diabetes
653 a hs-CRP
653 a hs-cTnI
653 a NT-proBNP
7001 a Goßling, Alinau Department for Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg, Germany4 aut
7001 a Magnussen, Christinau Department for Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Luebeck, Martinistrasse 52, Hamburg, Germany4 aut
7001 a Brenner, Hermannu German Cancer Research Center, Division of Clinical Epidemiology and Aging Research, Im Neuenheimer Feld 280, Heidelberg, Germany4 aut
7001 a Schöttker, Benu German Cancer Research Center, Division of Clinical Epidemiology and Aging Research, Im Neuenheimer Feld 280, Heidelberg, Germany4 aut
7001 a Iacoviello, Liciau 1) Department of Epidemiology and Prevention, IRCCS NEUROMED, Via Atinense ,18, Pozzilli, Italy; Research Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Via O. Rossi 9, Varese, Italy4 aut
7001 a Costanzo, Simonau 1) Department of Epidemiology and Prevention, IRCCS NEUROMED, Via Atinense ,18, Pozzilli, Italy4 aut
7001 a Kee, Franku Centre for Public Health, Queens University of Belfast, Belfast, United Kingdom4 aut
7001 a Koenig, Wolfgangu Klinik für Herz-& Kreislauferkrankungen, Deutsches Herzzentrum München, Technische Universität München, Lazarettstraße 36, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance ,Lazarettstraße 36, Munich, Germany; Institute of Epidemiology and Medical Biometry, University of Ulm, Helmholtzstr. 22, Ulm, Germany4 aut
7001 a Linneberg, Allanu Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Capital Region of Denmark, Ndr. Fasanvej 57, 1. sal, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark4 aut
7001 a Sujana, Chaterinau Helmholtz Zentrum München - German Research Center for Environmental Health, Institute of Epidemiology, Ingolstädter Landstraße 1, Germany4 aut
7001 a Thorand, Barbarau Helmholtz Zentrum München - German Research Center for Environmental Health, Institute of Epidemiology, Ingolstädter Landstraße 1, Germany; German Center for Diabetes Research (DZD), Ingolstädter Landstraße 1, Germany4 aut
7001 a Salomaa, Veikkou Finnish Institute for Health and Welfare, Department of Public Health and Welfare, P.O. Box 30, Helsinki, Finland4 aut
7001 a Niiranen, Teemu J.u Finnish Institute for Health and Welfare, Department of Public Health and Welfare, P.O. Box 30, Helsinki, Finland; Department of Medicine, Turku University Hospital and University of Turku, Kiinamyllynkatu 10, Turku, Finland4 aut
7001 a Söderberg, Stefanu Umeå universitet,Institutionen för folkhälsa och klinisk medicin4 aut0 (Swepub:umu)stso0001
7001 a Völzke, Henryu Institut für Community Medicine, University Medicine Greifswald ,Walter Rathenau Str. 48, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Greifswald ,Walter Rathenau Str. 48, Germany4 aut
7001 a Dörr, Marcusu German Center for Cardiovascular Research (DZHK), Partner Site Greifswald ,Walter Rathenau Str. 48, Germany; Klinik und Poliklinik für Innere Medizin B, University Medicine Greifswald ,Ferdinand-Sauerbruch-Straße, Germany4 aut
7001 a Sans, Susanau Catalan Department of Health, Roc Boronat, Barcelona, Spain4 aut
7001 a Padró, Teresau Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Barcelona, Spain4 aut
7001 a Felix, Stephan B.u German Center for Cardiovascular Research (DZHK), Partner Site Greifswald ,Walter Rathenau Str. 48, Germany; Klinik und Poliklinik für Innere Medizin B, University Medicine Greifswald ,Ferdinand-Sauerbruch-Straße, Germany4 aut
7001 a Nauck, Matthiasu German Center for Cardiovascular Research (DZHK), Partner Site Greifswald ,Walter Rathenau Str. 48, Germany; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald ,Ferdinand-Sauerbruch-Straße, Germany4 aut
7001 a Petersmann, Astridu Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald ,Ferdinand-Sauerbruch-Straße, Germany; University Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Oldenburg, Rahel-Straus-Straße 10, Oldenburg, Germany4 aut
7001 a Palmieri, Luigiu Department of Cardiovascular, Endocrine-metabolic Diseases and Aging, Istituto Superiore di Sanità-ISS, 299 Viale Regina Elena, Rome, Italy4 aut
7001 a Donfrancesco, Chiarau Department of Cardiovascular, Endocrine-metabolic Diseases and Aging, Istituto Superiore di Sanità-ISS, 299 Viale Regina Elena, Rome, Italy4 aut
7001 a De Ponti, Robertou Research Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Via O. Rossi 9, Varese, Italy4 aut
7001 a Veronesi, Giovanniu Research Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Via O. Rossi 9, Varese, Italy4 aut
7001 a Ferrario, Marco M.u Research Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Via O. Rossi 9, Varese, Italy4 aut
7001 a Kuulasmaa, Kariu Finnish Institute for Health and Welfare, Department of Public Health and Welfare, P.O. Box 30, Helsinki, Finland4 aut
7001 a Zeller, Tanjau Department for Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Luebeck, Martinistrasse 52, Hamburg, Germany4 aut
7001 a Ojeda, Francisco M.u Department for Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg, Germany4 aut
7001 a Blankenberg, Stefanu Department for Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Luebeck, Martinistrasse 52, Hamburg, Germany4 aut
7001 a Westermann, Dirku Department of Cardiology and Angiology, University Heart Center Freiburg • Bad Krozingen, Freiburg, Germany4 aut
7102 a Department for Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Luebeck, Martinistrasse 52, Hamburg, Germanyb Department for Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg, Germany4 org
7730 t European Journal of Preventive Cardiologyg 30:12, s. 1218-1226q 30:12<1218-1226x 2047-4873x 2047-4881
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-214279
8564 8u https://doi.org/10.1093/eurjpc/zwad122

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