Comparison of intake and systemic relative effect potencies of dioxin-like compounds in female rats after a single oral dose

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: onr:"swepub:oai:DiVA.org:umu-87392" > Comparison of intak...

1 av 1
Föregående post
Nästa post
Till träfflistan

LIBRIS Formathandbok (Information om MARC21)

Fältnamn	Indikatorer	Metadata
000		03701naa a2200421 4500
001		oai:DiVA.org:umu-87392
003		SwePub
008		140331s2014 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-873922 URI
024	7	a https://doi.org/10.1007/s00204-013-1186-22 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a van Ede, Karin I.u Univ Utrecht, Inst Risk Assessment Sci, NL-3508 TD Utrecht, Netherlands4 aut
245	1 0	a Comparison of intake and systemic relative effect potencies of dioxin-like compounds in female rats after a single oral dose
264		c 2013-12-21
264	1	a Heidelberg, Germany :b Springer,c 2014
338		a print2 rdacarrier
520		a Risk assessment for mixtures of dioxin-like compounds uses the toxic equivalency factor (TEF) approach. Although current WHO-TEFs are mostly based on oral administration, they are commonly used to determine toxicity equivalencies (TEQs) in human blood or tissues. However, the use of "intake" TEFs to calculate systemic TEQs in for example human blood, has never been validated. In this study, intake and systemic relative effect potencies (REPs) for 1,2,3,7,8-pentachlorodibenzo-p-dioxin (PeCDD), 2,3,4,7,8-pentachlorodibenzofuran (4-PeCDF), 3,3',4,4',5-pentachlorobiphenyl (PCB-126), 2,3',4,4',5-pentachlorobiphenyl (PCB-118) and 2,3,3',4,4',5-hexachlorobiphenyl (PCB-156) were compared in rats. The effect potencies were calculated based on administered dose and liver, adipose or plasma concentrations in female Sprague-Dawley rats 3 days after a single oral dose, relative to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Hepatic ethoxyresorufin-O-deethylase activity and gene expression of Cyp1a1, 1a2, 1b1 and aryl hydrocarbon receptor repressor in liver and peripheral blood lymphocytes were used as endpoints. Results show that plasma-based systemic REPs were generally within a half log range around the intake REPs for all congeners tested, except for 4-PeCDF. Together with our previously reported systemic REPs from a mouse study, these data do not warrant the use of systemic REPs as systemic TEFs for human risk assessment. However, further investigation for plasma-based systemic REPs for 4-PeCDF is desirable.
650	7	a NATURVETENSKAPx Kemi0 (SwePub)1042 hsv//swe
650	7	a NATURAL SCIENCESx Chemical Sciences0 (SwePub)1042 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng
653		a Dibenzofurans
653		a Dioxins
653		a PCBs
653		a Systemic REPs
653		a TEF concept
700	1	a Andersson, Patrik,d 1967-u Umeå universitet,Kemiska institutionen4 aut0 (Swepub:umu)paan0001
700	1	a Gaisch, Konrad P. J.u Univ Utrecht, Inst Risk Assessment Sci, NL-3508 TD Utrecht, Netherlands4 aut
700	1	a van den Berg, Martinu Univ Utrecht, Inst Risk Assessment Sci, NL-3508 TD Utrecht, Netherlands4 aut
700	1	a van Duursen, Majorie B. M.u Univ Utrecht, Inst Risk Assessment Sci, NL-3508 TD Utrecht, Netherlands4 aut
710	2	a Univ Utrecht, Inst Risk Assessment Sci, NL-3508 TD Utrecht, Netherlandsb Kemiska institutionen4 org
773	0	t Archives of Toxicologyd Heidelberg, Germany : Springerg 88:3, s. 637-646q 88:3<637-646x 0340-5761x 1432-0738
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-87392
856	4 8	u https://doi.org/10.1007/s00204-013-1186-2

Hitta via bibliotek

Archives of Toxicology (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

1 av 1
Föregående post
Nästa post
Till träfflistan

Hitta mer i SwePub

Av författaren/redakt...: van Ede, Karin I ...; Andersson, Patri ...; Gaisch, Konrad P ...; van den Berg, Ma ...; van Duursen, Maj ...

Om ämnet

NATURVETENSKAP: NATURVETENSKAP; och Kemi

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Farmakologi och ...

Artiklar i publikationen: Archives of Toxi ...

Av lärosätet: Umeå universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se