Search: onr:"swepub:oai:DiVA.org:uu-336245" > Associations betwee...
Fältnamn | Indikatorer | Metadata |
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000 | 03971naa a2200541 4500 | |
001 | oai:DiVA.org:uu-336245 | |
003 | SwePub | |
008 | 171213s2017 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-136189 | |
009 | oai:prod.swepub.kib.ki.se:135784161 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3362452 URI |
024 | 7 | a https://doi.org/10.1038/s41598-017-01553-22 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1361892 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1357841612 URI |
040 | a (SwePub)uud (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Schwartzbaum, Judith4 aut |
245 | 1 0 | a Associations between prediagnostic blood glucose levels, diabetes, and glioma. |
264 | c 2017-05-03 | |
264 | 1 | b Springer Science and Business Media LLC,c 2017 |
338 | a print2 rdacarrier | |
520 | a Previous literature indicates that pre-diagnostic diabetes and blood glucose levels are inversely related to glioma risk. To replicate these findings and determine whether they could be attributed to excess glucose consumption by the preclinical tumour, we used data from the Apolipoprotein MOrtality RISk (AMORIS) (n = 528,580) and the Metabolic syndrome and Cancer project (Me-Can) cohorts (n = 269,365). We identified individuals who were followed for a maximum of 15 years after their first blood glucose test until glioma diagnosis, death, emigration or the end of follow-up. Hazard ratios (HRs), 95% confidence intervals (CIs) and their interactions with time were estimated using Cox time-dependent regression. As expected, pre-diagnostic blood glucose levels were inversely related to glioma risk (AMORIS, P trend = 0.002; Me-Can, P trend = 0.04) and pre-diagnostic diabetes (AMORIS, HR = 0.30, 95% CI 0.17 to 0.53). During the year before diagnosis, blood glucose was inversely associated with glioma in the AMORIS (HR = 0.78, 95% CI 0.66 to 0.93) but not the Me-Can cohort (HR = 0.99, 95% CI 0.63 to 1.56). This AMORIS result is consistent with our hypothesis that excess glucose consumption by the preclinical tumour accounts for the inverse association between blood glucose and glioma. We discuss additional hypothetical mechanisms that may explain our paradoxical findings. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
700 | 1 | a Edlinger, Michael4 aut |
700 | 1 | a Zigmont, Victoria4 aut |
700 | 1 | a Stattin, Päru Umeå universitet,Uppsala universitet,Urologkirurgi,Urologi och andrologi4 aut0 (Swepub:umu)past0003 |
700 | 1 | a Rempala, Grzegorz A4 aut |
700 | 1 | a Nagel, Gabriele4 aut |
700 | 1 | a Hammar, Niklasu Karolinska Institutet4 aut |
700 | 1 | a Ulmer, Hanno4 aut |
700 | 1 | a Föger, Bernhard4 aut |
700 | 1 | a Walldius, Göranu Karolinska Institutet4 aut |
700 | 1 | a Manjer, Jonas4 aut |
700 | 1 | a Malmström, Håkanu Karolinska Institutet4 aut |
700 | 1 | a Feychting, Mariau Karolinska Institutet4 aut |
710 | 2 | a Uppsala universitetb Urologkirurgi4 org |
773 | 0 | t Scientific Reportsd : Springer Science and Business Media LLCg 7:1q 7:1x 2045-2322 |
856 | 4 | u https://www.nature.com/articles/s41598-017-01553-2.pdf |
856 | 4 | u https://doi.org/10.1038/s41598-017-01553-2y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1120811/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-336245 |
856 | 4 8 | u https://doi.org/10.1038/s41598-017-01553-2 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-136189 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:135784161 |
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