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FältnamnIndikatorerMetadata
00004732naa a2200469 4500
001oai:gup.ub.gu.se/205594
003SwePub
008240528s2015 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/2055942 URI
0247 a https://doi.org/10.1093/molbev/msu2852 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Ibstedt, Sebastian,d 1983u Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology4 aut0 (Swepub:gu)xibsse
2451 0a Concerted Evolution of Life Stage Performances Signals Recent Selection on Yeast Nitrogen Use.
264 c 2014-10-27
264 1b Oxford University Press (OUP),c 2015
520 a Exposing natural selection driving phenotypic and genotypic adaptive differentiation is an extraordinary challenge. Given that an organism's life stages are exposed to the same environmental variations, we reasoned that fitness components, such as the lag, rate, and efficiency of growth, directly reflecting performance in these life stages, should often be selected in concert. We therefore conjectured that correlations between fitness components over natural isolates, in a particular environmental context, would constitute a robust signal of recent selection. Critically, this test for selection requires fitness components to be determined by different genetic loci. To explore our conjecture, we exhaustively evaluated the lag, rate, and efficiency of asexual population growth of natural isolates of the model yeast Saccharomyces cerevisiae in a large variety of nitrogen-limited environments. Overall, fitness components were well correlated under nitrogen restriction. Yeast isolates were further crossed in all pairwise combinations and coinheritance of each fitness component and genetic markers were traced. Trait variations tended to map to quantitative trait loci (QTL) that were private to a single fitness component. We further traced QTLs down to single-nucleotide resolution and uncovered loss-of-function mutations in RIM15, PUT4, DAL1, and DAL4 as the genetic basis for nitrogen source use variations. Effects of SNPs were unique for a single fitness component, strongly arguing against pleiotropy between lag, rate, and efficiency of reproduction under nitrogen restriction. The strong correlations between life stage performances that cannot be explained by pleiotropy compellingly support adaptive differentiation of yeast nitrogen source use and suggest a generic approach for detecting selection.
650 7a NATURVETENSKAPx Biologix Evolutionsbiologi0 (SwePub)106152 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Evolutionary Biology0 (SwePub)106152 hsv//eng
650 7a NATURVETENSKAPx Biologix Genetik0 (SwePub)106092 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Genetics0 (SwePub)106092 hsv//eng
650 7a NATURVETENSKAPx Biologix Mikrobiologi0 (SwePub)106062 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Microbiology0 (SwePub)106062 hsv//eng
7001 a Stenberg, Simon4 aut
7001 a Bagés, Sarau Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology4 aut
7001 a Gjuvsland, Arne B4 aut
7001 a Salinas, Francisco4 aut
7001 a Kourtchenko, Olga,d 1980u Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology4 aut0 (Swepub:gu)xkouol
7001 a Samy, Jeevan K A4 aut
7001 a Blomberg, Anders,d 1956u Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Linnécentrum för marin evolutionsbiologi (CEMEB),Department of Chemistry and Molecular Biology,Linnaeus Centre for Marine Evolutionary Biology (CEMEB)4 aut0 (Swepub:gu)xbloan
7001 a Omholt, Stig W4 aut
7001 a Liti, Gianni4 aut
7001 a Beltran, Gemma4 aut
7001 a Warringer, Jonas,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology4 aut0 (Swepub:gu)xwarrj
7102 a Göteborgs universitetb Institutionen för kemi och molekylärbiologi4 org
7730 t Molecular biology and evolutiond : Oxford University Press (OUP)g 32:1, s. 153-161q 32:1<153-161x 1537-1719x 0737-4038
8564 u https://academic.oup.com/mbe/article-pdf/32/1/153/13170023/msu285.pdf
8564 8u https://gup.ub.gu.se/publication/205594
8564 8u https://doi.org/10.1093/molbev/msu285

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