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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004426naa a2200529 4500
001oai:gup.ub.gu.se/303165
003SwePub
008240528s2021 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/3031652 URI
0247 a https://doi.org/10.1136/ebmental-2020-3002402 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Furukawa, Toshi A.4 aut
2451 0a How can we estimate QALYs based on PHQ-9 scores? Equipercentile linking analysis of PHQ-9 and EQ-5D
264 c 2021-03-02
264 1b BMJ,c 2021
520 a Background: Quality-adjusted life years (QALYs) are widely used to measure the impact of various diseases on both the quality and quantity of life and in their economic valuations. It will be clinically important and informative if we can estimate QALYs based on measurements of depression severity. Objective: To construct a conversion table from the Patient Health Questionnaire-9 (PHQ-9), the most frequently used depression scale in recent years, to the Euro-Qol Five Dimensions Three Levels (EQ-5D-3L), one of the most commonly used instruments to assess QALYs. Methods: We obtained individual participant data of randomised controlled trials of internet cognitive-behavioural therapy which had administered depression severity scales and the EQ-5D-3L at baseline and at end of treatment. Scores from depression scales were all converted into the PHQ-9 according to the validated algorithms. We used equipercentile linking to establish correspondences between the PHQ-9 and the EQ-5D-3L. Findings: Individual-level data from five trials (total N=2457) were available. Subthreshold depression (PHQ-9 scores between 5 and 10) corresponded with EQ-5D-3L index values of 0.9-0.8, mild major depression (10-15) with 0.8-0.7, moderate depression (15-20) with 0.7-0.5 and severe depression (20 or higher) with 0.6-0.0. A five-point improvement in PHQ-9 corresponded approximately with an increase in EQ-5D-3L score by 0.03 and a ten-point improvement by approximately 0.25. Conclusions and Clinical Implications: The conversion table between the PHQ-9 and the EQ-5D-3L scores will enable fine-grained assessment of burden of depression at its various levels of severity and of impacts of its various treatments.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Allmänmedicin0 (SwePub)302242 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex General Practice0 (SwePub)302242 hsv//eng
653 a depression & mood disorders
7001 a Levine, Stephen Z.4 aut
7001 a Buntrock, Claudia4 aut
7001 a Ebert, David D.4 aut
7001 a Gilbody, Simon4 aut
7001 a Brabyn, Sally4 aut
7001 a Kessler, David4 aut
7001 a Björkelund, Cecilia,d 1948u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine4 aut0 (Swepub:gu)xbjoce
7001 a Eriksson, Maria Christina,d 1981u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine4 aut0 (Swepub:gu)xermay
7001 a Kleiboer, Annet4 aut
7001 a Van Straten, Annemieke4 aut
7001 a Riper, Heleen4 aut
7001 a Montero-Marin, Jesus4 aut
7001 a Garcia-Campayo, Javier4 aut
7001 a Phillips, Rachel4 aut
7001 a Schneider, Justine4 aut
7001 a Cuijpers, Pim4 aut
7001 a Karyotaki, Eirini4 aut
7102 a Göteborgs universitetb Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa4 org
7730 t Evidence-Based Mental Healthd : BMJg 24:3, s. 97-101q 24:3<97-101x 1362-0347x 1468-960X
8564 u https://ebmh.bmj.com/content/ebmental/24/3/97.full.pdf
8564 8u https://gup.ub.gu.se/publication/303165
8564 8u https://doi.org/10.1136/ebmental-2020-300240

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