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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004805naa a2200421 4500
001oai:lup.lub.lu.se:75e1f784-b163-48fa-ba41-17599f03278d
003SwePub
008181109s2019 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/75e1f784-b163-48fa-ba41-17599f03278d2 URI
0247 a https://doi.org/10.1080/0284186X.2018.15121532 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Edvardsson, Anneliu Lund University,Lunds universitet,Radiotherapy Physics,Forskargrupper vid Lunds universitet,Lund University Research Groups4 aut0 (Swepub:lu)med-ae5
2451 0a Comparative treatment planning study for mediastinal Hodgkin’s lymphoma : impact on normal tissue dose using deep inspiration breath hold proton and photon therapy
264 1c 2019
520 a Background: Late effects induced by radiotherapy (RT) are of great concern for mediastinal Hodgkin’s lymphoma (HL) patients and it is therefore important to reduce normal tissue dose. The aim of this study was to investigate the impact on the normal tissue dose and target coverage, using various combinations of intensity modulated proton therapy (IMPT), volumetric modulated arc therapy (VMAT) and 3-dimensional conformal RT (3D-CRT), planned in both deep inspiration breath hold (DIBH) and free breathing (FB). Material and methods: Eighteen patients were enrolled in this study and planned with involved site RT. Two computed tomography images were acquired for each patient, one during DIBH and one during FB. Six treatment plans were created for each patient; 3D-CRT in FB, 3D-CRT in DIBH, VMAT in FB, VMAT in DIBH, IMPT in FB and IMPT in DIBH. Dosimetric impact on the heart, left anterior descending (LAD) coronary artery, lungs, female breasts, target coverage, and also conformity index and integral dose (ID), was compared between the different treatment techniques. Results: The use of DIBH significantly reduced the lung dose for all three treatment techniques, however, no significant difference in the dose to the female breasts was observed. Regarding the heart and LAD doses, large individual variations were observed. For VMAT, the mean heart and LAD doses were significantly reduced using DIBH, but no significant difference was observed for 3D-CRT and IMPT. Both IMPT and VMAT resulted in improved target coverage and more conform dose distributions compared to 3D-CRT. IMPT generally showed the lowest organs at risk (OAR) doses and significantly reduced the ID compared to both 3D-CRT and VMAT. Conclusions: The majority of patients benefited from treatment in DIBH, however, the impact on the normal tissue dose was highly individual and therefore comparative treatment planning is encouraged. The lowest OAR doses were generally observed for IMPT in combination with DIBH.
650 7a NATURVETENSKAPx Fysikx Annan fysik0 (SwePub)103992 hsv//swe
650 7a NATURAL SCIENCESx Physical Sciencesx Other Physics Topics0 (SwePub)103992 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Kügele, Malinu Lund University,Lunds universitet,Radiotherapy Physics,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-mk7
7001 a Alkner, Sarau Lund University,Lunds universitet,Skåne University Hospital4 aut0 (Swepub:lu)med-srt
7001 a Enmark, Marikau Skåne University Hospital4 aut
7001 a Nilsson, Joakimu Skåne University Hospital4 aut
7001 a Kristensen, Ingridu Skåne University Hospital4 aut0 (Swepub:lu)med-ikt
7001 a Kjellén, Elisabethu Skåne University Hospital4 aut0 (Swepub:lu)onk-ekj
7001 a Engelholm, Silkeu Skåne University Hospital4 aut
7001 a Ceberg, Sofieu Lund University,Lunds universitet,Radiotherapy Physics,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-sem
7102 a Radiotherapy Physicsb Forskargrupper vid Lunds universitet4 org
7730 t Acta Oncologicag 58:1, s. 95-104q 58:1<95-104x 0284-186X
8564 u http://dx.doi.org/10.1080/0284186X.2018.1512153x freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/75e1f784-b163-48fa-ba41-17599f03278d
8564 8u https://doi.org/10.1080/0284186X.2018.1512153

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