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Sökning: onr:"swepub:oai:lup.lub.lu.se:cda31091-556c-4107-8f7f-1b5bc2d2f324" > Tumor Suppressor Pa...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04593naa a2200661 4500 | |
| 001 | oai:lup.lub.lu.se:cda31091-556c-4107-8f7f-1b5bc2d2f324 | |
| 003 | SwePub | |
| 008 | 220706s2022 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/cda31091-556c-4107-8f7f-1b5bc2d2f3242 URI |
| 024 | 7 | a https://doi.org/10.3389/fonc.2022.8604462 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Araujo, Nathaliau University of Kentucky4 aut |
| 245 | 1 0 | a Tumor Suppressor Par-4 Regulates Complement Factor C3 and Obesity |
| 264 | c 2022-03-29 | |
| 264 | 1 | b Frontiers Media SA,c 2022 |
| 520 | a Prostate apoptosis response-4 (Par-4) is a tumor suppressor that induces apoptosis in cancer cells. However, the physiological function of Par-4 remains unknown. Here we show that conventional Par-4 knockout (Par-4-/-) mice and adipocyte-specific Par-4 knockout (AKO) mice, but not hepatocyte-specific Par-4 knockout mice, are obese with standard chow diet. Par-4-/- and AKO mice exhibit increased absorption and storage of fat in adipocytes. Mechanistically, Par-4 loss is associated with mdm2 downregulation and activation of p53. We identified complement factor c3 as a p53-regulated gene linked to fat storage in adipocytes. Par-4 re-expression in adipocytes or c3 deletion reversed the obese mouse phenotype. Moreover, obese human subjects showed lower expression of Par-4 relative to lean subjects, and in longitudinal studies, low baseline Par-4 levels denoted an increased risk of developing obesity later in life. These findings indicate that Par-4 suppresses p53 and its target c3 to regulate obesity. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 650 | 7 | a NATURVETENSKAPx Biologix Cellbiologi0 (SwePub)106042 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Cell Biology0 (SwePub)106042 hsv//eng |
| 653 | a acylation stimulating protein | |
| 653 | a adipocyte tissue storage | |
| 653 | a C3 | |
| 653 | a fat absorption | |
| 653 | a hypertrophic obesity | |
| 653 | a Par-4 | |
| 700 | 1 | a Sledziona, Jamesu University of Kentucky4 aut |
| 700 | 1 | a Noothi, Sunil K.u University of Kentucky4 aut |
| 700 | 1 | a Burikhanov, Ravshanu University of Kentucky4 aut |
| 700 | 1 | a Hebbar, Nikhilu University of Kentucky4 aut |
| 700 | 1 | a Ganguly, Saptadwipau University of Kentucky4 aut |
| 700 | 1 | a Shrestha-Bhattarai, Triptiu Memorial Sloan-Kettering Cancer Center4 aut |
| 700 | 1 | a Zhu, Beibeiu University of Kentucky4 aut |
| 700 | 1 | a Katz, Wendy S.u University of Kentucky4 aut |
| 700 | 1 | a Zhang, Yiu University of Kentucky4 aut |
| 700 | 1 | a Taylor, Barry S.u Memorial Sloan-Kettering Cancer Center4 aut |
| 700 | 1 | a Liu, Jinzeu University of Kentucky4 aut |
| 700 | 1 | a Chen, Liu University of Kentucky Medical Center,University of Kentucky4 aut |
| 700 | 1 | a Weiss, Heidi L.u University of Kentucky Medical Center,University of Kentucky4 aut |
| 700 | 1 | a He, Dahengu University of Kentucky4 aut |
| 700 | 1 | a Wang, Chiu University of Kentucky Medical Center,University of Kentucky4 aut |
| 700 | 1 | a Morris, Andrew J.u University of Kentucky,University of Kentucky Medical Center4 aut |
| 700 | 1 | a Cassis, Lisa A.u University of Kentucky4 aut |
| 700 | 1 | a Nikolova-Karakashian, Marianau University of Kentucky,University of Kentucky Medical Center4 aut |
| 700 | 1 | a Nagareddy, Prabhakar R.u Ohio State University4 aut |
| 700 | 1 | a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)endo-ome |
| 700 | 1 | a Evers, B. Marku University of Kentucky Medical Center,University of Kentucky4 aut |
| 700 | 1 | a Kern, Philip A.u University of Kentucky4 aut |
| 700 | 1 | a Rangnekar, Vivek M.u University of Kentucky,University of Kentucky Medical Center4 aut |
| 710 | 2 | a University of Kentuckyb Memorial Sloan-Kettering Cancer Center4 org |
| 773 | 0 | t Frontiers in Oncologyd : Frontiers Media SAg 12q 12x 2234-943X |
| 856 | 4 | u http://dx.doi.org/10.3389/fonc.2022.860446x freey FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/cda31091-556c-4107-8f7f-1b5bc2d2f324 |
| 856 | 4 8 | u https://doi.org/10.3389/fonc.2022.860446 |
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