The effect of the mTOR inhibitor rapamycin on glucoCEST signal in a preclinical model of glioblastoma

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The effect of the mTOR inhibitor rapamycin on glucoCEST signal in a preclinical model of glioblastoma

Xu, Xiang (author): Johns Hopkins University

Xu, Jiadi (author): Johns Hopkins University

Knutsson, Linda (author): Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,MR Physics,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Johns Hopkins University

Liu, Jing (author): Johns Hopkins University,Affiliated Hospital of Guizhou Medical University

Liu, Huanling (author): Guangzhou Panyu Central Hospital,Johns Hopkins University

Li, Yuguo (author): Johns Hopkins University

Lal, Bachchu (author): Kennedy Krieger Institute

Laterra, John (author): Kennedy Krieger Institute,Johns Hopkins University

Artemov, Dmitri (author): Johns Hopkins University

Liu, Guanshu (author): Johns Hopkins University

van Zijl, Peter C.M. (author): Johns Hopkins University

Chan, Kannie W.Y. (author): University of Hong Kong,Johns Hopkins University

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2019-02-22
2019
English.
In: Magnetic Resonance in Medicine. - : Wiley. - 0740-3194. ; 81:6, s. 3798-3807

Related links:: http://dx.doi.org/10...; show more...; https://europepmc.or...; https://lup.lub.lu.s...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Purpose: The mammalian target of rapamycin is an enzyme that regulates cell metabolism and proliferation. It is up-regulated in aggressive tumors, such as glioblastoma, leading to increased glucose uptake and consumption. It has been suggested that glucose CEST signals reflect the delivery and tumor uptake of glucose. The inhibitor rapamycin (sirolimus) has been applied as a glucose deprivation treatment; thus, glucose CEST MRI could potentially be useful for monitoring the tumor responses to inhibitor treatment. Methods: A human U87-EGFRvIII xenograft model in mice was studied. The mice were treated with a mammalian target of Rapamycin inhibitor, rapamycin. The effect of the treatment was evaluated in vivo with dynamic glucose CEST MRI. Results: Rapamycin treatment led to significant increases (P < 0.001) in dynamic glucose-enhanced signal in both the tumor and contralateral brain as compared to the no-treatment group, namely a maximum enhancement of 3.7% ± 2.3% (tumor, treatment) versus 1.9% ± 0.4% (tumor, no-treatment), 1.7% ± 1.1% (contralateral, treatment), and 1.0% ± 0.4% (contralateral, no treatment). Dynamic glucose-enhanced contrast remained consistently higher in treatment versus no-treatment groups for the duration of the experiment (17 min). This was confirmed with area-under-curve analysis. Conclusion: Increased glucose CEST signal was found after mammalian target of Rapamycin inhibition treatment, indicating potential for dynamic glucose-enhanced MRI to study tumor response to glucose deprivation treatment.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
NATURVETENSKAP -- Fysik -- Annan fysik (hsv//swe)
NATURAL SCIENCES -- Physical Sciences -- Other Physics Topics (hsv//eng)

Keyword

DGE MRI
glioblastoma
glucoCEST
mTOR inhibitor
preclinical imaging
rapamycin

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By the author/editor: Xu, Xiang; Xu, Jiadi; Knutsson, Linda; Liu, Jing; Liu, Huanling; Li, Yuguo; show more...; Lal, Bachchu; Laterra, John; Artemov, Dmitri; Liu, Guanshu; van Zijl, Peter ...; Chan, Kannie W.Y ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Radiology Nuclea ...

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By the university: Lund University

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