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Disruption of chrom...
Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer
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- Akdemir, KC (author)
- University of Texas MD Anderson Cancer Center
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- Le, VTT (author)
- Salk Institute for Biological Studies
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- Chandran, S (author)
- Salk Institute for Biological Studies
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- Li, YL (author)
- Wellcome Trust Sanger Institute
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- Verhaak, RG (author)
- QIMR Berghofer Medical Research Institute
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- Beroukhim, R (author)
- Dana-Farber Cancer Institute
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- Campbell, PJ (author)
- Wellcome Trust Sanger Institute
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- Chin, L (author)
- University of Texas
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- Dixon, JR (author)
- Salk Institute for Biological Studies
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- Futreal, PA (author)
- University of Texas MD Anderson Cancer Center
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Alvarez, EG (author)
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Baez-Ortega, A (author)
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Beroukhim, R (author)
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Boutros, PC (author)
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Bowtell, DDL (author)
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Brors, B (author)
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Burns, KH (author)
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Chan, K (author)
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Chen, K (author)
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Cortes-Ciriano, I (author)
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Dueso-Barroso, A (author)
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Dunford, AJ (author)
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Edwards, PA (author)
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Estivill, X (author)
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Etemadmoghadam, D (author)
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Feuerbach, L (author)
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Fink, JL (author)
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Frenkel-Morgenstern, M (author)
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Garsed, DW (author)
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Gerstein, M (author)
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Gordenin, DA (author)
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Haan, D (author)
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Haber, JE (author)
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Hess, JM (author)
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Hutter, B (author)
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Imielinski, M (author)
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Jones, DTW (author)
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Ju, YS (author)
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Kazanov, MD (author)
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Klimczak, LJ (author)
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Koh, Y (author)
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Korbel, JO (author)
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Kumar, K (author)
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Lee, EA (author)
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Lee, JJK (author)
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Lynch, AG (author)
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Macintyre, G (author)
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Markowetz, F (author)
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Martincorena, I (author)
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Martinez-Fundichely, A (author)
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Meyerson, M (author)
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Miyano, S (author)
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Nakagawa, H (author)
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Navarro, FCP (author)
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Ossowski, S (author)
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Park, PJ (author)
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Pearson, JV (author)
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Puiggros, M (author)
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Rippe, K (author)
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Roberts, ND (author)
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Roberts, SA (author)
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Rodriguez-Martin, B (author)
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Schumacher, SE (author)
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Scully, R (author)
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Shackleton, M (author)
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Sidiropoulos, N (author)
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Sieverling, L (author)
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Stewart, C (author)
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Torrents, D (author)
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Tubio, JMC (author)
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Villasante, I (author)
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Waddell, N (author)
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Wala, JA (author)
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Weischenfeldt, J (author)
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Yang, LX (author)
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Yao, XT (author)
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Yoon, SS (author)
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Zamora, J (author)
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Zhang, CZ (author)
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- Borg, Åke (creator_code:cre_t)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Familjär bröstcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Familial Breast Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Ringnér, Markus (creator_code:cre_t)
- Lund University,Lunds universitet,Molekylär cellbiologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Molecular Cell Biology,Department of Biology,Faculty of Science
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- Staaf, Johan (creator_code:cre_t)
- Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/lungcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Research Group Lung Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/lungcancer,Section I,Department of Clinical Sciences, Lund
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(creator_code:org_t)
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- 2020-02-05
- 2020
- English.
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In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 52:3, s. 294-
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http://dx.doi.org/10... (free)
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Abstract
Subject headings
Close
- Chromatin is folded into successive layers to organize linear DNA. Genes within the same topologically associating domains (TADs) demonstrate similar expression and histone-modification profiles, and boundaries separating different domains have important roles in reinforcing the stability of these features. Indeed, domain disruptions in human cancers can lead to misregulation of gene expression. However, the frequency of domain disruptions in human cancers remains unclear. Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA), which aggregated whole-genome sequencing data from 2,658 cancers across 38 tumor types, we analyzed 288,457 somatic structural variations (SVs) to understand the distributions and effects of SVs across TADs. Notably, SVs can lead to the fusion of discrete TADs, and complex rearrangements markedly change chromatin folding maps in the cancer genomes. Notably, only 14% of the boundary deletions resulted in a change in expression in nearby genes of more than twofold.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- Chromatin/genetics
- Gene Expression Regulation, Neoplastic
- Gene Rearrangement/genetics
- Genome, Human/genetics
- Genomic Structural Variation
- Humans
- Neoplasms/genetics
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Akdemir, KC
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Le, VTT
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Chandran, S
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Li, YL
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Verhaak, RG
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Beroukhim, R
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show more...
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Campbell, PJ
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Chin, L
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Dixon, JR
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Futreal, PA
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Alvarez, EG
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Baez-Ortega, A
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Boutros, PC
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Bowtell, DDL
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Brors, B
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Burns, KH
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Chan, K
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Chen, K
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Cortes-Ciriano, ...
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Dueso-Barroso, A
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Dunford, AJ
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Edwards, PA
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Estivill, X
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Etemadmoghadam, ...
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Feuerbach, L
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Fink, JL
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Frenkel-Morgenst ...
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Garsed, DW
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Gerstein, M
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Gordenin, DA
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Haan, D
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Haber, JE
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Hess, JM
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Hutter, B
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Imielinski, M
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Jones, DTW
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Ju, YS
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Kazanov, MD
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Klimczak, LJ
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Koh, Y
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Korbel, JO
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Kumar, K
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Lee, EA
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Lee, JJK
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Lynch, AG
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Macintyre, G
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Markowetz, F
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Martincorena, I
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Martinez-Fundich ...
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Meyerson, M
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Miyano, S
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Nakagawa, H
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Navarro, FCP
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Ossowski, S
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Park, PJ
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Pearson, JV
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Puiggros, M
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Rippe, K
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Roberts, ND
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Roberts, SA
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Rodriguez-Martin ...
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Schumacher, SE
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Scully, R
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Shackleton, M
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Sidiropoulos, N
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Sieverling, L
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Stewart, C
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Torrents, D
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Tubio, JMC
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Villasante, I
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Waddell, N
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Wala, JA
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Weischenfeldt, J
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Yang, LX
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Yao, XT
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Yoon, SS
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Zamora, J
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Zhang, CZ
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Borg, Åke
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Ringnér, Markus
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Staaf, Johan
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Nature genetics
- By the university
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Karolinska Institutet
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Lund University