Cocaine-Induced Breakdown of the Blood–Brain Barrier and Neurotoxicity

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Fältnamn	Indikatorer	Metadata
000		02458naa a2200313 4500
001		oai:DiVA.org:uu-113373
003		SwePub
008		100128s2009 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1133732 URI
024	7	a https://doi.org/10.1016/S0074-7742(09)88011-22 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a for2 swepub-publicationtype
100	1	a Sharma, Hari Shankeru Uppsala universitet,Anestesiologi och intensivvård4 aut0 (Swepub:uu)hssharma
245	1 0	a Cocaine-Induced Breakdown of the Blood–Brain Barrier and Neurotoxicity
264	1	c 2009
338		a print2 rdacarrier
520		a Role of cocaine in influencing blood-brain barrier (BBB) function is still unknown. Available evidences suggest that cocaine administration results in acute hyperthermia and alterations in brain serotonin metabolism. Since hyperthermia is capable to induce the breakdown of the BBB either directly or through altered serotonin metabolism, a possibility exists that cocaine may induce neurotoxicity by causing BBB disruption. This hypothesis is discussed in this review largely based on our own laboratory investigations. Our observations in rats demonstrate that cocaine depending on the dose and routes of administration induces profound hyperthermia, increased plasma and brain serotonin levels leading to BBB breakdown and brain edema formation. Furthermore, cocaine was able to enhance cellular stress as seen by upregulation of heat shock protein (HSP 72 kD) expression and resulted in marked neuronal and glial cell damages at the time of the BBB dysfunction. Taken together, these observations are the first to suggest that cocaine-induced BBB disruption is instrumental in precipitating brain pathology. The possible mechanisms of cocaine-induced BBB breakdown and neurotoxicity are discussed.
653		a MEDICINE
653		a MEDICIN
700	1	a Muresanu, Dafin4 aut
700	1	a Sharma, Arunau Uppsala universitet,Anestesiologi och intensivvård4 aut0 (Swepub:uu)arush975
700	1	a Patnaik, Ranjana4 aut
710	2	a Uppsala universitetb Anestesiologi och intensivvård4 org
773	0	t International review of neurobiologyg 88, s. 297-334q 88<297-334x 0074-7742x 2162-5514
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-113373
856	4 8	u https://doi.org/10.1016/S0074-7742(09)88011-2

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International review of neurobiology (Sök värdpublikationen i LIBRIS)

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Av författaren/redakt...: Sharma, Hari Sha ...; Muresanu, Dafin; Sharma, Aruna; Patnaik, Ranjana

Artiklar i publikationen: International re ...

Av lärosätet: Uppsala universitet

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