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Risk factors for pe...
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Droppa, MichalUniv Hosp Tubingen, Germany
(author)
Risk factors for permanent pacemaker implantation in patients receiving a balloon-expandable transcatheter aortic valve prosthesis
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-06-26
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Springer,2020
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-167734
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-167734URI
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https://doi.org/10.1007/s00380-020-01653-6DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|Edwards Lifesciences (Nyon, Switzerland)
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Permanent pacemaker implantation (PPI) is a widely recognized complication associated with TAVI (incidence up to 20%). Smaller registries have identified several variables associated with PPI. The objective was to validate patient- and transcatheter aortic valve implantation (TAVI)-related procedural variables associated with PPI. We performed a retrospective analysis of patients from six European centers undergoing TAVI with the Edwards SAPIEN 3 prosthesis. Baseline variables and pre-procedural ECG characteristics and CT-scans were taken into account. Data for 1745 patients were collected; 191 (10.9%) required PPI after TAVI. The baseline variables pulmonary hypertension (OR 1.64; 95% CI 1.01-2.59), QRS duration > 117 ms (OR 2.58; 95% CI 1.73-3.84), right bundle branch block (RBBB; OR 5.14; 95% CI 3.39-7.72), left anterior hemi block (OR 1.92; 95% CI 1.19-3.02) and first-degree atrioventricular block (AVB, OR 1.63; 95%CI 1.05-2.46) were significantly associated with PPI. RBBB (OR 8.11; 95% CI 3.19-21.86) and first-degree AVB (OR 2.39; 95% CI 1.18-4.66) remained significantly associated in a multivariate analysis. Procedure-related variables included access site (TF; OR 1.97; 95% CI 1.07-4.05), implanted valve size (29 mm; OR 1.88; 95% CI 1.35-2.59), mean TAVI valve implantation depth below the annulus > 30% (OR 3.75; 95% CI 2.01-6.98). Patients receiving PPI had longer ICU stays and later discharges. Acute kidney injury stage 2/3 was more common in patients with PPI until discharge (15.2 vs. 3.1%;p = 0.007), but was not statistically significant thereafter. Further differences in outcomes at 30 days did not reach significance. The data will aid pre- and post-procedural patient management and prevent adverse long-term outcomes. Clinical Trial: NCT03497611.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Rudolph, Tanja K.Cologne Univ, Germany; Heart and Diabet Ctr NRW, Germany
(author)
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Baan, JanUniv Amsterdam, Netherlands
(author)
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Nielsen, Niels Erik,1956-Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)nieni36
(author)
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Baumgartner, HelmutUniv Hosp Muenster, Germany
(author)
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Vendrik, JeroenUniv Amsterdam, Netherlands
(author)
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Froehlich, MarenInst Pharmacol and Prevent Med, Germany
(author)
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Borst, OliverUniv Hosp Tubingen, Germany
(author)
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Woehrle, JochenUniv Ulm, Germany
(author)
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Gawaz, MeinradUniv Hosp Tubingen, Germany
(author)
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Potratz, PaulUniv Hosp Tubingen, Germany
(author)
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Hack, Luis P.Univ Hosp Tubingen, Germany
(author)
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Mauri, VictorCologne Univ, Germany
(author)
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Baranowski, JacekRegion Östergötland, Kardiologiska kliniken US(Swepub:liu)n/a
(author)
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Bramlage, PeterInst Pharmacol and Prevent Med, Germany
(author)
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Kurucova, JanaEdwards Lifesci, Czech Republic
(author)
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Thoenes, MartinEdwards Lifesci, Switzerland
(author)
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Rottbauer, WolfgangUniv Ulm, Germany
(author)
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Geisler, TobiasUniv Hosp Tubingen, Germany
(author)
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Univ Hosp Tubingen, GermanyCologne Univ, Germany; Heart and Diabet Ctr NRW, Germany
(creator_code:org_t)
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In:Heart and Vessels: Springer35, s. 1735-17450910-83271615-2573
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Droppa, Michal
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Rudolph, Tanja K ...
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Baan, Jan
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Nielsen, Niels E ...
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Baumgartner, Hel ...
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Vendrik, Jeroen
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Froehlich, Maren
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Borst, Oliver
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Woehrle, Jochen
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Gawaz, Meinrad
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Potratz, Paul
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Hack, Luis P.
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Mauri, Victor
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Baranowski, Jace ...
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Bramlage, Peter
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Kurucova, Jana
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Thoenes, Martin
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Rottbauer, Wolfg ...
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Geisler, Tobias
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Linköping University