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  • Droppa, MichalUniv Hosp Tubingen, Germany (author)

Risk factors for permanent pacemaker implantation in patients receiving a balloon-expandable transcatheter aortic valve prosthesis

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-06-26
  • Springer,2020
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-167734
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-167734URI
  • https://doi.org/10.1007/s00380-020-01653-6DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Edwards Lifesciences (Nyon, Switzerland)
  • Permanent pacemaker implantation (PPI) is a widely recognized complication associated with TAVI (incidence up to 20%). Smaller registries have identified several variables associated with PPI. The objective was to validate patient- and transcatheter aortic valve implantation (TAVI)-related procedural variables associated with PPI. We performed a retrospective analysis of patients from six European centers undergoing TAVI with the Edwards SAPIEN 3 prosthesis. Baseline variables and pre-procedural ECG characteristics and CT-scans were taken into account. Data for 1745 patients were collected; 191 (10.9%) required PPI after TAVI. The baseline variables pulmonary hypertension (OR 1.64; 95% CI 1.01-2.59), QRS duration > 117 ms (OR 2.58; 95% CI 1.73-3.84), right bundle branch block (RBBB; OR 5.14; 95% CI 3.39-7.72), left anterior hemi block (OR 1.92; 95% CI 1.19-3.02) and first-degree atrioventricular block (AVB, OR 1.63; 95%CI 1.05-2.46) were significantly associated with PPI. RBBB (OR 8.11; 95% CI 3.19-21.86) and first-degree AVB (OR 2.39; 95% CI 1.18-4.66) remained significantly associated in a multivariate analysis. Procedure-related variables included access site (TF; OR 1.97; 95% CI 1.07-4.05), implanted valve size (29 mm; OR 1.88; 95% CI 1.35-2.59), mean TAVI valve implantation depth below the annulus > 30% (OR 3.75; 95% CI 2.01-6.98). Patients receiving PPI had longer ICU stays and later discharges. Acute kidney injury stage 2/3 was more common in patients with PPI until discharge (15.2 vs. 3.1%;p = 0.007), but was not statistically significant thereafter. Further differences in outcomes at 30 days did not reach significance. The data will aid pre- and post-procedural patient management and prevent adverse long-term outcomes. Clinical Trial: NCT03497611.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Rudolph, Tanja K.Cologne Univ, Germany; Heart and Diabet Ctr NRW, Germany (author)
  • Baan, JanUniv Amsterdam, Netherlands (author)
  • Nielsen, Niels Erik,1956-Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)nieni36 (author)
  • Baumgartner, HelmutUniv Hosp Muenster, Germany (author)
  • Vendrik, JeroenUniv Amsterdam, Netherlands (author)
  • Froehlich, MarenInst Pharmacol and Prevent Med, Germany (author)
  • Borst, OliverUniv Hosp Tubingen, Germany (author)
  • Woehrle, JochenUniv Ulm, Germany (author)
  • Gawaz, MeinradUniv Hosp Tubingen, Germany (author)
  • Potratz, PaulUniv Hosp Tubingen, Germany (author)
  • Hack, Luis P.Univ Hosp Tubingen, Germany (author)
  • Mauri, VictorCologne Univ, Germany (author)
  • Baranowski, JacekRegion Östergötland, Kardiologiska kliniken US(Swepub:liu)n/a (author)
  • Bramlage, PeterInst Pharmacol and Prevent Med, Germany (author)
  • Kurucova, JanaEdwards Lifesci, Czech Republic (author)
  • Thoenes, MartinEdwards Lifesci, Switzerland (author)
  • Rottbauer, WolfgangUniv Ulm, Germany (author)
  • Geisler, TobiasUniv Hosp Tubingen, Germany (author)
  • Univ Hosp Tubingen, GermanyCologne Univ, Germany; Heart and Diabet Ctr NRW, Germany (creator_code:org_t)

Related titles

  • In:Heart and Vessels: Springer35, s. 1735-17450910-83271615-2573

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