L773:1440 1711 OR L773:0818 9641
Search: L773:1440 1711 OR L773:0818 9641 > Harnessing the immu...
- 10 of 39
- Previous record
- Next record
- To hitlist
Harnessing the immune system via Fc gamma R function in immune therapy : a pathway to next-gen mAbs
-
- Chenoweth, Alicia M. (author)
- Burnet Inst, Immune Therapies Lab, Melbourne, Vic, Australia.;Monash Univ, Cent Clin Sch, Dept Pathol & Immunol, Melbourne, Vic, Australia.;Kings Coll London, St Johns Inst Dermatol, London, England.;Kings Coll London, London, England.
-
- Wines, Bruce D. (author)
- Burnet Inst, Immune Therapies Lab, Melbourne, Vic, Australia.;Monash Univ, Cent Clin Sch, Dept Pathol & Immunol, Melbourne, Vic, Australia.;Univ Melbourne, Dept Clin Pathol, Parkville, Vic, Australia.
-
- Anania, Jessica (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Burnet Inst, Immune Therapies Lab, Melbourne, Vic, Australia.;Monash Univ, Cent Clin Sch, Dept Pathol & Immunol, Melbourne, Vic, Australia.
- show more...
- show less...
- Burnet Inst, Immune Therapies Lab, Melbourne, Vic, Australia;Monash Univ, Cent Clin Sch, Dept Pathol & Immunol, Melbourne, Vic, Australia.;Kings Coll London, St Johns Inst Dermatol, London, England.;Kings Coll London, London, England. Burnet Inst, Immune Therapies Lab, Melbourne, Vic, Australia.;Monash Univ, Cent Clin Sch, Dept Pathol & Immunol, Melbourne, Vic, Australia.;Univ Melbourne, Dept Clin Pathol, Parkville, Vic, Australia. (creator_code:org_t)
- 2020-04-12
- 2020
- English.
- In: Immunology and Cell Biology. - : WILEY. - 0818-9641 .- 1440-1711. ; 98:4, s. 287-304
- Research review (peer-reviewed)
Abstract
Subject headings
Close
- The human fragment crystallizable (Fc)gamma receptor (R) interacts with antigen-complexed immunoglobulin (Ig)G ligands to both activate and modulate a powerful network of inflammatory host-protective effector functions that are key to the normal physiology of immune resistance to pathogens. More than 100 therapeutic monoclonal antibodies (mAbs) are approved or in late stage clinical trials, many of which harness the potent Fc gamma R-mediated effector systems to varying degrees. This is most evident for antibodies targeting cancer cells inducing antibody-dependent killing or phagocytosis but is also true to some degree for the mAbs that neutralize or remove small macromolecules such as cytokines or other Igs. The use of mAb therapeutics has also revealed a "scaffolding" role for Fc gamma R which, in different contexts, may either underpin the therapeutic mAb action such as immune agonism or trigger catastrophic adverse effects. The still unmet therapeutic need in many cancers, inflammatory diseases or emerging infections such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires increased effort on the development of improved and novel mAbs. A more mature appreciation of the immunobiology of individual Fc gamma R function and the complexity of the relationships between Fc gamma Rs and antibodies is fueling efforts to develop more potent "next-gen" therapeutic antibodies. Such development strategies now include focused glycan or protein engineering of the Fc to increase affinity and/or tailor specificity for selective engagement of individual activating Fc gamma Rs or the inhibitory Fc gamma RIIb or alternatively, for the ablation of Fc gamma R interaction altogether. This review touches on recent aspects of Fc gamma R and IgG immunobiology and its relationship with the present and future actions of therapeutic mAbs.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Keyword
- ADCC
- Fc receptors
- immune therapy
- monoclonal antibodies
- phagocytosis
- SARS-CoV-2
Publication and Content Type
- ref (subject category)
- for (subject category)
Find in a library
- Immunology and Cell Biology (Search for host publication in LIBRIS)
To the university's database
- 10 of 39
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Chenoweth, Alici ...
- Wines, Bruce D.
- Anania, Jessica
- Hogarth, P.
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Immunology in th ...
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Biological Scien ...
- and Immunology
- Articles in the publication
- Immunology and C ...
- By the university
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
