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  • Ni, RuiqingUniv Zurich, Switzerland; Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland; Univ Zurich, Switzerland (författare)

Multiscale optical and optoacoustic imaging of amyloid-beta deposits in mice

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2022-07-14
  • NATURE PORTFOLIO,2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-187387
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-187387URI
  • https://doi.org/10.1038/s41551-022-00906-1DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies|European Research Council [ERC-2015-CoG-682379]; US National Institutes of Health [UF1-NS107680]; Swiss National Science Foundation [310030_192757]; Swedish Research Council [2016-00748]; Nomis Distinguished Scientist Award. J.K. received funding from the Swiss National Science Foundation [320030_179277, 32NE30_173678/1]; Synapsis foundation; Vontobel foundation; Synapsis foundation career development award [2017 CDA-03]; UZH Innovation [MEDEF20-021]; Helmut Horten Stiftung; Vontobel Stiftung; Jubilaumsstiftung von Swiss Life; European Union [746430]
  • Large-field multifocal illumination fluorescence microscopy and panoramic volumetric multispectral optoacoustic tomography can be combined to longitudinally assess amyloid-beta deposits in transgenic mouse models of Alzheimers disease. Deposits of amyloid-beta (A beta) in the brains of rodents can be analysed by invasive intravital microscopy on a submillimetre scale, or via whole-brain images from modalities lacking the resolution or molecular specificity to accurately characterize A beta pathologies. Here we show that large-field multifocal illumination fluorescence microscopy and panoramic volumetric multispectral optoacoustic tomography can be combined to longitudinally assess A beta deposits in transgenic mouse models of Alzheimers disease. We used fluorescent A beta-targeted probes (the luminescent conjugated oligothiophene HS-169 and the oxazine-derivative AOI987) to transcranially detect A beta deposits in the cortex of APP/PS1 and arcA beta mice with single-plaque resolution (8 mu m) and across the whole brain (including the hippocampus and the thalamus, which are inaccessible by conventional intravital microscopy) at sub-150 mu m resolutions. Two-photon microscopy, light-sheet microscopy and immunohistochemistry of brain-tissue sections confirmed the specificity and regional distributions of the deposits. High-resolution multiscale optical and optoacoustic imaging of A beta deposits across the entire brain in rodents thus facilitates the in vivo study of A beta accumulation by brain region and by animal age and strain.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Chen, ZhenyueUniv Zurich, Switzerland; Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland (författare)
  • Dean-Ben, Xose LuisUniv Zurich, Switzerland; Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland (författare)
  • Voigt, Fabian F.Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland; Univ Zurich, Switzerland (författare)
  • Kirschenbaum, DanielUniv Spital Zurich, Switzerland (författare)
  • Shi, GloriaUniv Zurich, Switzerland; Swiss Fed Inst Technol, Switzerland (författare)
  • Villois, AlessiaSwiss Fed Inst Technol, Switzerland (författare)
  • Zhou, QuanyuUniv Zurich, Switzerland; Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland (författare)
  • Crimi, AlessandroUniv Spital Zurich, Switzerland (författare)
  • Arosio, PaoloSwiss Fed Inst Technol, Switzerland (författare)
  • Nitsch, Roger M.Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland; Univ Zurich, Switzerland (författare)
  • Nilsson, Peter,1970-Linköpings universitet,Kemi,Tekniska fakulteten(Swepub:liu)petni61 (författare)
  • Aguzzi, AdrianoSwiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland; Univ Spital Zurich, Switzerland (författare)
  • Helmchen, FritjofSwiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland; Univ Zurich, Switzerland (författare)
  • Klohs, JanUniv Zurich, Switzerland; Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland (författare)
  • Razansky, DanielUniv Zurich, Switzerland; Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland; Univ Zurich, Switzerland (författare)
  • Univ Zurich, Switzerland; Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland; Univ Zurich, SwitzerlandUniv Zurich, Switzerland; Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Nature Biomedical Engineering: NATURE PORTFOLIO6, s. 1031-10442157-846X

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