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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005308naa a2200481 4500
001oai:DiVA.org:liu-187387
003SwePub
008220822s2022 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1873872 URI
0247 a https://doi.org/10.1038/s41551-022-00906-12 DOI
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Ni, Ruiqingu Univ Zurich, Switzerland; Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland; Univ Zurich, Switzerland4 aut
2451 0a Multiscale optical and optoacoustic imaging of amyloid-beta deposits in mice
264 c 2022-07-14
264 1b NATURE PORTFOLIO,c 2022
338 a print2 rdacarrier
500 a Funding Agencies|European Research Council [ERC-2015-CoG-682379]; US National Institutes of Health [UF1-NS107680]; Swiss National Science Foundation [310030_192757]; Swedish Research Council [2016-00748]; Nomis Distinguished Scientist Award. J.K. received funding from the Swiss National Science Foundation [320030_179277, 32NE30_173678/1]; Synapsis foundation; Vontobel foundation; Synapsis foundation career development award [2017 CDA-03]; UZH Innovation [MEDEF20-021]; Helmut Horten Stiftung; Vontobel Stiftung; Jubilaumsstiftung von Swiss Life; European Union [746430]
520 a Large-field multifocal illumination fluorescence microscopy and panoramic volumetric multispectral optoacoustic tomography can be combined to longitudinally assess amyloid-beta deposits in transgenic mouse models of Alzheimers disease. Deposits of amyloid-beta (A beta) in the brains of rodents can be analysed by invasive intravital microscopy on a submillimetre scale, or via whole-brain images from modalities lacking the resolution or molecular specificity to accurately characterize A beta pathologies. Here we show that large-field multifocal illumination fluorescence microscopy and panoramic volumetric multispectral optoacoustic tomography can be combined to longitudinally assess A beta deposits in transgenic mouse models of Alzheimers disease. We used fluorescent A beta-targeted probes (the luminescent conjugated oligothiophene HS-169 and the oxazine-derivative AOI987) to transcranially detect A beta deposits in the cortex of APP/PS1 and arcA beta mice with single-plaque resolution (8 mu m) and across the whole brain (including the hippocampus and the thalamus, which are inaccessible by conventional intravital microscopy) at sub-150 mu m resolutions. Two-photon microscopy, light-sheet microscopy and immunohistochemistry of brain-tissue sections confirmed the specificity and regional distributions of the deposits. High-resolution multiscale optical and optoacoustic imaging of A beta deposits across the entire brain in rodents thus facilitates the in vivo study of A beta accumulation by brain region and by animal age and strain.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
7001 a Chen, Zhenyueu Univ Zurich, Switzerland; Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland4 aut
7001 a Dean-Ben, Xose Luisu Univ Zurich, Switzerland; Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland4 aut
7001 a Voigt, Fabian F.u Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland; Univ Zurich, Switzerland4 aut
7001 a Kirschenbaum, Danielu Univ Spital Zurich, Switzerland4 aut
7001 a Shi, Gloriau Univ Zurich, Switzerland; Swiss Fed Inst Technol, Switzerland4 aut
7001 a Villois, Alessiau Swiss Fed Inst Technol, Switzerland4 aut
7001 a Zhou, Quanyuu Univ Zurich, Switzerland; Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland4 aut
7001 a Crimi, Alessandrou Univ Spital Zurich, Switzerland4 aut
7001 a Arosio, Paolou Swiss Fed Inst Technol, Switzerland4 aut
7001 a Nitsch, Roger M.u Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland; Univ Zurich, Switzerland4 aut
7001 a Nilsson, Peter,d 1970-u Linköpings universitet,Kemi,Tekniska fakulteten4 aut0 (Swepub:liu)petni61
7001 a Aguzzi, Adrianou Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland; Univ Spital Zurich, Switzerland4 aut
7001 a Helmchen, Fritjofu Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland; Univ Zurich, Switzerland4 aut
7001 a Klohs, Janu Univ Zurich, Switzerland; Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland4 aut
7001 a Razansky, Danielu Univ Zurich, Switzerland; Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland; Univ Zurich, Switzerland4 aut
7102 a Univ Zurich, Switzerland; Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland; Univ Zurich, Switzerlandb Univ Zurich, Switzerland; Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland4 org
7730 t Nature Biomedical Engineeringd : NATURE PORTFOLIOg 6, s. 1031-1044q 6<1031-1044x 2157-846X
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-187387
8564 8u https://doi.org/10.1038/s41551-022-00906-1

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