Age-associated changes in hypothalamic-pituitary-testicular function in middle-aged and older men are modified by weight change and lifestyle factors: longitudinal results from the European Male Ageing Study

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Boonen S) > Age-associated chan...

LIBRIS Formathandbok (Information om MARC21)

Fältnamn	Indikatorer	Metadata
000		04075naa a2200505 4500
001		oai:lup.lub.lu.se:c8e66ff0-528f-44fe-a9aa-8554dabec2ce
003		SwePub
008		160401s2013 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/37651612 URI
024	7	a https://doi.org/10.1530/EJE-12-08902 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Camacho, E. M.4 aut
245	1 0	a Age-associated changes in hypothalamic-pituitary-testicular function in middle-aged and older men are modified by weight change and lifestyle factors: longitudinal results from the European Male Ageing Study
264	1	c 2013
520		a Objective: Health and lifestyle factors are associated with variations in serum testosterone levels in ageing men. However, it remains unclear how age-related changes in testosterone may be attenuated by lifestyle modifications. The objective was to investigate the longitudinal relationships between changes in health and lifestyle factors with changes in hormones of the reproductive endocrine axis in ageing men. Design: A longitudinal survey of 2736 community-dwelling men aged 40-79 years at baseline recruited from eight centres across Europe. Follow-up assessment occurred mean (+/- S.D.) 4.4 +/- 0.3 years later. Results: Paired testosterone results were available for 2395 men. Mean (+/- S.D.) annualised hormone changes were as follows: testosterone -0.1 +/- 0.95 nmol/l; free testosterone (FT) -3.83 +/- 16.8 pmol/l; sex hormone-binding globulin (SHBG) 0.56 +/- 2.5 nmol/l and LH 0.08 +/- 0.57 U/l. Weight loss was associated with a proportional increase, and weight gain a proportional decrease, in testosterone and SHBG. FT showed a curvilinear relationship to weight change; only those who gained or lost >= 15% of weight showed a significant change (in the same direction as testosterone). Smoking cessation was associated with a greater decline in testosterone than being a non-smoker, which was unrelated to weight change. Changes in number of comorbid conditions or physical activity were not associated with significant alterations in hypothalamic-pituitary-testicular (HPT) axis function. Conclusions: Body weight and lifestyle factors influence HPT axis function in ageing. Weight loss was associated with a rise, and weight gain a fall, in testosterone, FT and SHBG. Weight management appears to be important in maintaining circulating testosterone in ageing men, and obesity-associated changes in HPT axis hormones are reversible following weight reduction. European Journal of Endocrinology 168 445-455
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
700	1	a Huhtaniemi, I. T.4 aut
700	1	a O'Neill, T. W.4 aut
700	1	a Finn, J. D.4 aut
700	1	a Pye, S. R.4 aut
700	1	a Lee, D. M.4 aut
700	1	a Tajar, A.4 aut
700	1	a Bartfai, G.4 aut
700	1	a Boonen, S.4 aut
700	1	a Casanueva, F. F.4 aut
700	1	a Forti, G.4 aut
700	1	a Giwercman, Aleksanderu Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)kir-agi
700	1	a Han, T. S.4 aut
700	1	a Kula, K.4 aut
700	1	a Keevil, B.4 aut
700	1	a Lean, M. E.4 aut
700	1	a Pendleton, N.4 aut
700	1	a Punab, M.4 aut
700	1	a Vanderschueren, D.4 aut
700	1	a Wu, F. C. W.4 aut
710	2	a Reproduktionsmedicin, Malmöb Forskargrupper vid Lunds universitet4 org
773	0	t European Journal of Endocrinologyg 168:3, s. 445-455q 168:3<445-455x 1479-683X
856	4	u http://dx.doi.org/10.1530/EJE-12-0890y FULLTEXT
856	4 8	u https://lup.lub.lu.se/record/3765161
856	4 8	u https://doi.org/10.1530/EJE-12-0890

Hitta via bibliotek

European Journal of Endocrinology (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Camacho, E. M.; Huhtaniemi, I. T ...; O'Neill, T. W.; Finn, J. D.; Pye, S. R.; Lee, D. M.; visa fler...; Tajar, A.; Bartfai, G.; Boonen, S.; Casanueva, F. F.; Forti, G.; Giwercman, Aleks ...; Han, T. S.; Kula, K.; Keevil, B.; Lean, M. E.; Pendleton, N.; Punab, M.; Vanderschueren, ...; Wu, F. C. W.; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Endokrinologi oc ...

Artiklar i publikationen: European Journal ...

Av lärosätet: Lunds universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se