pol gene sequence variation in Swedish HIV-2 patients failing antiretroviral therapy

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Fältnamn	Indikatorer	Metadata
000		04950naa a2200817 4500
001		oai:gup.ub.gu.se/83664
003		SwePub
008		240528s2003 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://gup.ub.gu.se/publication/836642 URI
040		a (SwePub)gu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Brandin, Eleonor4 aut
245	1 0	a pol gene sequence variation in Swedish HIV-2 patients failing antiretroviral therapy
264	1	c 2003
520		a There is limited knowledge about how to treat and interpret results from genotypic resistance assays in HIV-2 infection. Here, genetic variation in HIV-2 pol gene was studied in 20 of 23 known HIV-2 cases in Sweden. Five patients with signs of virological treatment failure were longitudinally studied. Clinical, virological and immunological data were collected and the protease (PR) and first half of the reverse transcriptase (RT) was amplified and directly sequenced from plasma samples. Moderate to extensive genetic evolution was observed in four of the five patients who failed treatment. Some mutations occurred at positions known to confer resistance in HIV-1, but many occurred at other positions in PR and RT. All patients had been treated with zidovudine alone or in combination with other antiretroviral drugs, but none displayed a mutation at position 215, which is the primary zidovudine resistance site in HIV-1. Instead, a E219D mutation evolved in virus from two patients and a Q151M mutation evolved in two other patients. A M184V mutation indicative of lamivudine resistance was detected in three patients. The virus of one patient who had been treated with ritonavir, nelfinavir, and lopinavir successively acquired nine unusual mutations in the protease gene, most of which are not considered primary or secondary resistance mutations in HIV-1. Our data indicate that the evolutionary pathways that lead to antiretroviral resistance in HIV-2 and HIV-1 exhibit both similarities and differences. Genotypic HIV-2 resistance assays cannot be interpreted using algorithms developed for HIV-1, instead new algorithms specific for HIV-2 have to be developed.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng
653		a Adolescent
653		a Adult
653		a Africa
653		a Western/ethnology
653		a Amino Acid Sequence
653		a Amino Acid Substitution
653		a Anti-HIV Agents/pharmacology/therapeutic use
653		a Codon/genetics
653		a Drug Resistance
653		a Multiple
653		a Viral/*genetics
653		a Evolution
653		a Molecular
653		a Female
653		a *Genes
653		a pol
653		a HIV Infections/drug therapy/*virology
653		a HIV Protease Inhibitors/pharmacology/therapeutic use
653		a HIV-1/drug effects/genetics
653		a HIV-2/drug effects/*genetics/isolation & purification
653		a Humans
653		a Lamivudine/pharmacology/therapeutic use
653		a Male
653		a Middle Aged
653		a Molecular Sequence Data
653		a *Mutation
653		a Missense
653		a Nelfinavir/pharmacology/therapeutic use
653		a Prospective Studies
653		a Pyrimidinones/pharmacology/therapeutic use
653		a Reverse Transcriptase Inhibitors/pharmacology/therapeutic use
653		a Ritonavir/pharmacology/therapeutic use
653		a Sequence Alignment
653		a Sequence Homology
653		a Amino Acid
653		a Sweden
653		a Treatment Failure
653		a Variation (Genetics)
653		a Viremia/drug therapy/*virology
653		a Zidovudine/pharmacology/therapeutic use
700	1	a Lindborg, Lena4 aut
700	1	a Gyllensten, Katarina4 aut
700	1	a Broström, Christina4 aut
700	1	a Hagberg, Lars,d 1951u Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för infektionssjukdomar,Institute of Internal Medicine, Dept of Infectious Diseases4 aut0 (Swepub:gu)xhagbl
700	1	a Gisslén, Magnus,d 1962u Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för infektionssjukdomar,Institute of Internal Medicine, Dept of Infectious Diseases4 aut0 (Swepub:gu)xgissm
700	1	a Tuvesson, Björn4 aut
700	1	a Blaxhult, Anders4 aut
700	1	a Albert, Jan4 aut
710	2	a Göteborgs universitetb Institutionen för invärtesmedicin, Avdelningen för infektionssjukdomar4 org
773	0	t AIDS Res Hum Retrovirusesg 19:7, s. 543-50q 19:7<543-50
856	4 8	u https://gup.ub.gu.se/publication/83664

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