Powerful protein binders from designed polypeptides and small organic molecules : a general concept for protein recognition

• High-affinity binders for the C-reactive protein (CRP), with dissociation constants in the pM to nM range and selectivities in human serum comparable to those of antibodies, were obtained by conjugation of 16 designed polypeptides to phosphocholine, a small molecule that binds CRP with a KDvalue of 5I . The polypeptides were not designed specifically to recognize CRP and bind by an adapted fit mechanism.

Subject headings

NATURVETENSKAP  -- Kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences (hsv//eng)

Keyword

bioorganic chemistry

C-reactive protein

phosphocholine

polypeptides

proteins

Chemistry

Kemi

MEDICINE

MEDICIN

Publication and Content Type

ref (subject category)

art (subject category)