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Sökning: WFRF:(Chernogubova Ekaterina) > β₁-Adrenergic recep...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003896naa a2200421 4500
001oai:DiVA.org:su-70772
003SwePub
008120124s2011 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-707722 URI
0247 a https://doi.org/10.1152/ajpendo.00085.20112 DOI
040 a (SwePub)su
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Mattsson, Charlotte L.u Stockholms universitet,Avdelningen för fysiologi4 aut
2451 0a β₁-Adrenergic receptors increase UCP1 in human MADS brown adipocytes and rescue cold-acclimated β₃-adrenergic receptor-knockout mice via nonshivering thermogenesis
264 1b American Physiological Society,c 2011
338 a print2 rdacarrier
520 a With the finding that brown adipose tissue is present and negatively correlated to obesity in adult man, finding the mechanism(s) of how to activate brown adipose tissue in humans could be important in combating obesity, type 2 diabetes, and their complications. In mice, the main regulator of nonshivering thermogenesis in brown adipose tissue is norepinephrine acting predominantly via β(3)-adrenergic receptors. However, vast majorities of β(3)-adrenergic agonists have so far not been able to stimulate human β(3)-adrenergic receptors or brown adipose tissue activity, and it was postulated that human brown adipose tissue could be regulated instead by β(1)-adrenergic receptors. Therefore, we have investigated the signaling pathways, specifically pathways to nonshivering thermogenesis, in mice lacking β(3)-adrenergic receptors. Wild-type and β(3)-knockout mice were either exposed to acute cold (up to 12 h) or acclimated for 7 wk to cold, and parameters related to metabolism and brown adipose tissue function were investigated. β(3)-knockout mice were able to survive both acute and prolonged cold exposure due to activation of β(1)-adrenergic receptors. Thus, in the absence of β(3)-adrenergic receptors, β(1)-adrenergic receptors are effectively able to signal via cAMP to elicit cAMP-mediated responses and to recruit and activate brown adipose tissue. In addition, we found that in human multipotent adipose-derived stem cells differentiated into functional brown adipocytes, activation of either β(1)-adrenergic receptors or β(3)-adrenergic receptors was able to increase UCP1 mRNA and protein levels. Thus, in humans, β(1)-adrenergic receptors could play an important role in regulating nonshivering thermogenesis.
650 7a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng
653 a uncoupling protein 1
653 a brown adipose tissue
653 a obesity
653 a type 2 diabetes
653 a human multipotent adipose-derived stem cells
7001 a Csikasz, Robert I.u Stockholms universitet,Avdelningen för fysiologi4 aut0 (Swepub:su)rocs5038
7001 a Chernogubova, Ekaterinau Stockholms universitet,Avdelningen för fysiologi4 aut
7001 a Yamamoto, Daniel L.u Stockholms universitet,Avdelningen för fysiologi4 aut
7001 a Högberg, Helena T.u Stockholms universitet,Avdelningen för fysiologi4 aut
7001 a Amri, Ez-Zoubir4 aut
7001 a Hutchinson, Dana S.u Stockholms universitet,Avdelningen för fysiologi4 aut
7001 a Bengtsson, Toreu Stockholms universitet,Avdelningen för fysiologi4 aut0 (Swepub:su)tbeng
7102 a Stockholms universitetb Avdelningen för fysiologi4 org
7730 t American Journal of Physiology. Endocrinology and Metabolismd : American Physiological Societyg 301:6, s. E1108-E1118q 301:6<E1108-E1118x 0193-1849x 1522-1555
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-70772
8564 8u https://doi.org/10.1152/ajpendo.00085.2011

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