WFRF:(Daub M.)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02795naa a2200373 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:139087231 | |
| 003 | SwePub | |
| 008 | 240701s2018 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1390872312 URI |
| 024 | 7 | a https://doi.org/10.1038/s41598-018-30702-42 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Alhendi, AMN4 aut |
| 245 | 1 0 | a Promoter Usage and Dynamics in Vascular Smooth Muscle Cells Exposed to Fibroblast Growth Factor-2 or Interleukin-1β |
| 264 | c 2018-09-03 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2018 |
| 520 | a Smooth muscle cells (SMC) in blood vessels are normally growth quiescent and transcriptionally inactive. Our objective was to understand promoter usage and dynamics in SMC acutely exposed to a prototypic growth factor or pro-inflammatory cytokine. Using cap analysis gene expression (FANTOM5 project) we report differences in promoter dynamics for immediate-early genes (IEG) and other genes when SMC are exposed to fibroblast growth factor-2 or interleukin-1β. Of the 1871 promoters responding to FGF2 or IL-1β considerably more responded to FGF2 (68.4%) than IL-1β (18.5%) and 13.2% responded to both. Expression clustering reveals sets of genes induced, repressed or unchanged. Among IEG responding rapidly to FGF2 or IL-1β were FOS, FOSB and EGR-1, which mediates human SMC migration. Motif activity response analysis (MARA) indicates most transcription factor binding motifs in response to FGF2 were associated with a sharp induction at 1 h, whereas in response to IL-1β, most motifs were associated with a biphasic change peaking generally later. MARA revealed motifs for FOS_FOS{B,L1}_JUN{B,D} and EGR-1..3 in the cluster peaking 1 h after FGF2 exposure whereas these motifs were in clusters peaking 1 h or later in response to IL-1β. Our findings interrogating CAGE data demonstrate important differences in promoter usage and dynamics in SMC exposed to FGF2 or IL-1β. | |
| 700 | 1 | a Patrikakis, M4 aut |
| 700 | 1 | a Daub, COu Karolinska Institutet4 aut |
| 700 | 1 | a Kawaji, H4 aut |
| 700 | 1 | a Itoh, M4 aut |
| 700 | 1 | a de Hoon, M4 aut |
| 700 | 1 | a Carninci, P4 aut |
| 700 | 1 | a Hayashizaki, Y4 aut |
| 700 | 1 | a Arner, E4 aut |
| 700 | 1 | a Khachigian, LM4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Scientific reportsd : Springer Science and Business Media LLCg 8:1, s. 13164-q 8:1<13164-x 2045-2322 |
| 856 | 4 | u https://doi.org/10.1038/s41598-018-30702-4 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:139087231 |
| 856 | 4 8 | u https://doi.org/10.1038/s41598-018-30702-4 |
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