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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 10819naa a2202737 4500 | |
| 001 | oai:DiVA.org:su-119245 | |
| 003 | SwePub | |
| 008 | 150803s2015 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:131574811 | |
| 009 | oai:DiVA.org:uu-260145 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1192452 URI |
| 024 | 7 | a https://doi.org/10.1016/j.jalz.2014.05.17572 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1315748112 URI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2601452 URI |
| 040 | a (SwePub)sud (SwePub)kid (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Jones, Lesley4 aut |
| 245 | 1 0 | a Convergent genetic and expression data implicate immunity in Alzheimer's disease |
| 264 | c 2014-12-19 | |
| 264 | 1 | b Wiley,c 2015 |
| 338 | a print2 rdacarrier | |
| 520 | a Background: Late-onset Alzheimer's disease (AD) is heritable with 20 genes showing genome-wide association in the International Genomics of Alzheimer's Project (IGAP). To identify the biology underlying the disease, we extended these genetic data in a pathway analysis. Methods: The ALIGATOR and GSEA algorithms were used in the IGAP data to identify associated functional pathways and correlated gene expression networks in human brain. Results: ALIGATOR identified an excess of curated biological pathways showing enrichment of association. Enriched areas of biology included the immune response (P = 3.27 X 10(-12) after multiple testing correction for pathways), regulation of endocytosis (P = 1.31 X 10(-11)), cholesterol transport (P = 2.96 X 10(-9)), and proteasome-ubiquitin activity (P = 1.34 X 10(-6)). Correlated gene expression analysis identified four significant network modules, all related to the immune response (corrected P = .002-.05). Conclusions: The immime response, regulation of endocytosis, cholesterol transport, and protein ubiquitination represent prime targets for AD therapeutics. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
| 653 | a Alzheimer's disease | |
| 653 | a Dementia | |
| 653 | a Neurodegeneration | |
| 653 | a Immune response | |
| 653 | a Endocytosis | |
| 653 | a Cholesterol metabolism | |
| 653 | a Ubiquitination | |
| 653 | a Pathway analysis | |
| 653 | a ALIGATOR | |
| 653 | a Weighted gene co-expression network analysis | |
| 700 | 1 | a Lambert, Jean-Charles4 aut |
| 700 | 1 | a Wang, Li-San4 aut |
| 700 | 1 | a Choi, Seung-Hoan4 aut |
| 700 | 1 | a Harold, Denise4 aut |
| 700 | 1 | a Vedernikov, Alexey4 aut |
| 700 | 1 | a Escott-Price, Valentina4 aut |
| 700 | 1 | a Stone, Timothy4 aut |
| 700 | 1 | a Richards, Alexander4 aut |
| 700 | 1 | a Bellenguez, Celine4 aut |
| 700 | 1 | a Ibrahim-Verbaas, Carla A.4 aut |
| 700 | 1 | a Naj, Adam C.4 aut |
| 700 | 1 | a Sims, Rebecca4 aut |
| 700 | 1 | a Gerrish, Amy4 aut |
| 700 | 1 | a Jun, Gyungah4 aut |
| 700 | 1 | a Lannfelt, Larsu Uppsala universitet,Geriatrik4 aut0 (Swepub:uu)lalan021 |
| 700 | 1 | a Bis, Joshua C.4 aut |
| 700 | 1 | a Beecham, Gary W.4 aut |
| 700 | 1 | a Grenier-Boley, Benjamin4 aut |
| 700 | 1 | a Russo, Giancarlo4 aut |
| 700 | 1 | a Thornton-Wells, Tricia A.4 aut |
| 700 | 1 | a Jones, Nicola4 aut |
| 700 | 1 | a Smith, Albert V.4 aut |
| 700 | 1 | a Chouraki, Vincent4 aut |
| 700 | 1 | a Thomas, Charlene4 aut |
| 700 | 1 | a Ikram, M. Arfan4 aut |
| 700 | 1 | a Zelenika, Diana4 aut |
| 700 | 1 | a Vardarajan, Badri N.4 aut |
| 700 | 1 | a Kamatani, Yoichiro4 aut |
| 700 | 1 | a Lin, Chiao-Feng4 aut |
| 700 | 1 | a Schmidt, Helena4 aut |
| 700 | 1 | a Kunkle, Brian W.4 aut |
| 700 | 1 | a Dunstan, Melanie L.4 aut |
| 700 | 1 | a Ruiz, Agustin4 aut |
| 700 | 1 | a Bihoreau, Marie-Therese4 aut |
| 700 | 1 | a Reitz, Christiane4 aut |
| 700 | 1 | a Pasquier, Florence4 aut |
| 700 | 1 | a Hollingworth, Paul4 aut |
| 700 | 1 | a Hanon, Olivier4 aut |
| 700 | 1 | a Fitzpatrick, Annette L.4 aut |
| 700 | 1 | a Buxbaum, Joseph D.4 aut |
| 700 | 1 | a Campion, Dominique4 aut |
| 700 | 1 | a Crane, Paul K.4 aut |
| 700 | 1 | a Becker, Tim4 aut |
| 700 | 1 | a Gudnason, Vilmundur4 aut |
| 700 | 1 | a Cruchaga, Carlosu Karolinska Institutet4 aut |
| 700 | 1 | a Craig, David4 aut |
| 700 | 1 | a Amin, Najaf4 aut |
| 700 | 1 | a Berr, Claudine4 aut |
| 700 | 1 | a Lopez, Oscar L.4 aut |
| 700 | 1 | a De Jager, Philip L.4 aut |
| 700 | 1 | a Deramecourt, Vincent4 aut |
| 700 | 1 | a Johnston, Janet A.4 aut |
| 700 | 1 | a Evans, Denis4 aut |
| 700 | 1 | a Lovestone, Simon4 aut |
| 700 | 1 | a Letteneur, Lucu Karolinska Institutet4 aut |
| 700 | 1 | a Kornhuber, Johanes4 aut |
| 700 | 1 | a Tarraga, Lluis4 aut |
| 700 | 1 | a Rubinsztein, David C.4 aut |
| 700 | 1 | a Eiriksdottir, Gudny4 aut |
| 700 | 1 | a Sleegers, Kristel4 aut |
| 700 | 1 | a Goate, Alison M.4 aut |
| 700 | 1 | a Fievet, Nathalie4 aut |
| 700 | 1 | a Huentelman, Matthew J.4 aut |
| 700 | 1 | a Gill, Michael4 aut |
| 700 | 1 | a Emilsson, Valur4 aut |
| 700 | 1 | a Brown, Kristelle4 aut |
| 700 | 1 | a Kamboh, M. Ilyas4 aut |
| 700 | 1 | a Keller, Linau Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)4 aut |
| 700 | 1 | a Barberger-Gateau, Pascale4 aut |
| 700 | 1 | a McGuinness, Bernadette4 aut |
| 700 | 1 | a Larson, Eric B.4 aut |
| 700 | 1 | a Myers, Amanda J.4 aut |
| 700 | 1 | a Dufouil, Carole4 aut |
| 700 | 1 | a Todd, Stephen4 aut |
| 700 | 1 | a Wallon, David4 aut |
| 700 | 1 | a Love, Seth4 aut |
| 700 | 1 | a Kehoe, Pat4 aut |
| 700 | 1 | a Rogaeva, Ekaterina4 aut |
| 700 | 1 | a Gallacher, John4 aut |
| 700 | 1 | a St George-Hyslop, Peter4 aut |
| 700 | 1 | a Clarimon, Jordi4 aut |
| 700 | 1 | a Lleo, Alberti4 aut |
| 700 | 1 | a Bayer, Anthony4 aut |
| 700 | 1 | a Tsuang, Debby W.4 aut |
| 700 | 1 | a Yu, Lei4 aut |
| 700 | 1 | a Tsolaki, Magda4 aut |
| 700 | 1 | a Bossu, Paola4 aut |
| 700 | 1 | a Spalletta, Gianfranco4 aut |
| 700 | 1 | a Proitsi, Petra4 aut |
| 700 | 1 | a Collinge, John4 aut |
| 700 | 1 | a Sorbi, Sandro4 aut |
| 700 | 1 | a Garcia, Fiorentino Sanchez4 aut |
| 700 | 1 | a Fox, Nick4 aut |
| 700 | 1 | a Hardy, John4 aut |
| 700 | 1 | a Deniz Naranjo, Maria Candida4 aut |
| 700 | 1 | a Razquin, Cristina4 aut |
| 700 | 1 | a Bosco, Paola4 aut |
| 700 | 1 | a Clarke, Robert4 aut |
| 700 | 1 | a Brayne, Carol4 aut |
| 700 | 1 | a Galimberti, Daniela4 aut |
| 700 | 1 | a Mancuso, Michelangelo4 aut |
| 700 | 1 | a Moebus, Susanne4 aut |
| 700 | 1 | a Mecocci, Patrizia4 aut |
| 700 | 1 | a del Zompo, Maria4 aut |
| 700 | 1 | a Maier, Wolfgang4 aut |
| 700 | 1 | a Hampel, Harald4 aut |
| 700 | 1 | a Pilotto, Alberto4 aut |
| 700 | 1 | a Bullido, Maria4 aut |
| 700 | 1 | a Panza, Francesco4 aut |
| 700 | 1 | a Caffarra, Paolo4 aut |
| 700 | 1 | a Nacmias, Benedetta4 aut |
| 700 | 1 | a Gilbert, John R.4 aut |
| 700 | 1 | a Mayhaus, Manuel4 aut |
| 700 | 1 | a Jessen, Frank4 aut |
| 700 | 1 | a Dichgans, Martin4 aut |
| 700 | 1 | a Lannfelt, Lars4 aut |
| 700 | 1 | a Hakonarson, Hakon4 aut |
| 700 | 1 | a Pichler, Sabrina4 aut |
| 700 | 1 | a Carrasquillo, Minerva M.4 aut |
| 700 | 1 | a Ingelsson, Martinu Uppsala universitet,Geriatrik4 aut0 (Swepub:uu)maing121 |
| 700 | 1 | a Beekly, Duane4 aut |
| 700 | 1 | a Alavarez, Victoria4 aut |
| 700 | 1 | a Zou, Fanggeng4 aut |
| 700 | 1 | a Valladares, Otto4 aut |
| 700 | 1 | a Younkin, Steven G.4 aut |
| 700 | 1 | a Coto, Eliecer4 aut |
| 700 | 1 | a Hamilton-Nelson, Kara L.4 aut |
| 700 | 1 | a Mateo, Ignacio4 aut |
| 700 | 1 | a Owen, Michael J.4 aut |
| 700 | 1 | a Faber, Kelley M.4 aut |
| 700 | 1 | a Jonsson, Palmi V.4 aut |
| 700 | 1 | a Combarros, Onofre4 aut |
| 700 | 1 | a O'Donovan, Michael C.4 aut |
| 700 | 1 | a Cantwell, Laura B.4 aut |
| 700 | 1 | a Soininen, Hilkka4 aut |
| 700 | 1 | a Blacker, Deborah4 aut |
| 700 | 1 | a Mead, Simon4 aut |
| 700 | 1 | a Mosley, Thomas H.4 aut |
| 700 | 1 | a Bennett, David A.4 aut |
| 700 | 1 | a Harris, Tamara B.4 aut |
| 700 | 1 | a Fratiglioni, Laurau Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Karolinska University Hospital, Sweden4 aut |
| 700 | 1 | a Holmes, Clive4 aut |
| 700 | 1 | a de Bruijn, Renee F. A. G.4 aut |
| 700 | 1 | a Passmore, Peter4 aut |
| 700 | 1 | a Montine, Thomas J.4 aut |
| 700 | 1 | a Bettens, Karolien4 aut |
| 700 | 1 | a Rotter, Jerome I.4 aut |
| 700 | 1 | a Brice, Alexis4 aut |
| 700 | 1 | a Morgan, Kevin4 aut |
| 700 | 1 | a Foroud, Tatiana M.4 aut |
| 700 | 1 | a Kukull, Walter A.4 aut |
| 700 | 1 | a Hannequin, Didier4 aut |
| 700 | 1 | a Powell, John F.4 aut |
| 700 | 1 | a Nails, Michael A.4 aut |
| 700 | 1 | a Ritchie, Karen4 aut |
| 700 | 1 | a Lunetta, Kathryn L.4 aut |
| 700 | 1 | a Kauwe, John S. K.4 aut |
| 700 | 1 | a Boerwinkle, Eric4 aut |
| 700 | 1 | a Riemenschneider, Matthias4 aut |
| 700 | 1 | a Boada, Merce4 aut |
| 700 | 1 | a Hiltunen, Mikko4 aut |
| 700 | 1 | a Martin, Eden R.4 aut |
| 700 | 1 | a Pastor, Pau4 aut |
| 700 | 1 | a Schmidt, Reinhold4 aut |
| 700 | 1 | a Rujescu, Dan4 aut |
| 700 | 1 | a Dartigues, Jean-Francois4 aut |
| 700 | 1 | a Mayeux, Richard4 aut |
| 700 | 1 | a Tzourio, Christophe4 aut |
| 700 | 1 | a Hofman, Albert4 aut |
| 700 | 1 | a Noethen, Markus M.4 aut |
| 700 | 1 | a Graff, Caroline4 aut |
| 700 | 1 | a Psaty, Bruce M.4 aut |
| 700 | 1 | a Haines, Jonathan L.4 aut |
| 700 | 1 | a Lathrop, Mark4 aut |
| 700 | 1 | a Pericak-Vance, Margaret A.4 aut |
| 700 | 1 | a Launer, Lenore J.4 aut |
| 700 | 1 | a Farrer, Lindsay A.4 aut |
| 700 | 1 | a van Duijn, Cornelia M.4 aut |
| 700 | 1 | a Van Broeckhoven, Christine4 aut |
| 700 | 1 | a Ramirez, Alfredo4 aut |
| 700 | 1 | a Schellenberg, Gerard D.4 aut |
| 700 | 1 | a Seshadri, Sudha4 aut |
| 700 | 1 | a Amouyel, Philippe4 aut |
| 700 | 1 | a Williams, Julie4 aut |
| 700 | 1 | a Holmans, Peter A.4 aut |
| 710 | 2 | a Uppsala universitetb Geriatrik4 org |
| 773 | 0 | t Alzheimer's & Dementiad : Wileyg 11:6, s. 658-671q 11:6<658-671x 1552-5260x 1552-5279 |
| 856 | 4 | u https://europepmc.org/articles/pmc4672734?pdf=render |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-119245 |
| 856 | 4 8 | u https://doi.org/10.1016/j.jalz.2014.05.1757 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:131574811 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-260145 |
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