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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003780naa a2200529 4500
001oai:DiVA.org:uu-219274
003SwePub
008140225s2014 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:128124512
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2192742 URI
0247 a https://doi.org/10.1111/joim.121622 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1281245122 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a for2 swepub-publicationtype
1001 a Husebye, E. S.4 aut
2451 0a Consensus statement on the diagnosis, treatment and follow-up of patients with primary adrenal insufficiency
264 c 2013-12-16
264 1b Wiley,c 2014
338 a print2 rdacarrier
520 a Primary adrenal insufficiency (PAI), or Addison's disease, is a rare, potentially deadly, but treatable disease. Most cases of PAI are caused by autoimmune destruction of the adrenal cortex. Consequently, patients with PAI are at higher risk of developing other autoimmune diseases. The diagnosis of PAI is often delayed by many months, and most patients present with symptoms of acute adrenal insufficiency. Because PAI is rare, even medical specialists in this therapeutic area rarely manage more than a few patients. Currently, the procedures for diagnosis, treatment and follow-up of this rare disease vary greatly within Europe. The common autoimmune form of PAI is characterized by the presence of 21-hydroxylase autoantibodies; other causes should be sought if no autoantibodies are detected. Acute adrenal crisis is a life-threatening condition that requires immediate treatment. Standard replacement therapy consists of multiple daily doses of hydrocortisone or cortisone acetate combined with fludrocortisone. Annual follow-up by an endocrinologist is recommended with the focus on optimization of replacement therapy and detection of new autoimmune diseases. Patient education to enable self-adjustment of dosages of replacement therapy and crisis prevention is particularly important in this disease. The authors of this document have collaborated within an EU project (Euadrenal) to study the pathogenesis, describe the natural course and improve the treatment for Addison's disease. Based on a synthesis of this research, the available literature, and the views and experiences of the consortium's investigators and key experts, we now attempt to provide a European Expert Consensus Statement for diagnosis, treatment and follow-up.
653 a 21-hydroxylase
653 a Addison's disease
653 a adrenal crisis
653 a autoimmune polyendocrine syndrome
653 a cortisol
7001 a Allolio, B.4 aut
7001 a Arlt, W.4 aut
7001 a Badenhoop, K.4 aut
7001 a Bensing, S.u Karolinska Institutet4 aut
7001 a Betterle, C.4 aut
7001 a Falorni, A.4 aut
7001 a Gan, E. H.4 aut
7001 a Hulting, A. -Lu Karolinska Institutet4 aut
7001 a Kasperlik-Zaluska, A.4 aut
7001 a Kämpe, Olleu Karolinska Institutet,Uppsala universitet,Autoimmunitet4 aut0 (Swepub:uu)ollekamp
7001 a Lovas, K.4 aut
7001 a Meyer, G.4 aut
7001 a Pearce, S. H.4 aut
7102 a Karolinska Institutetb Autoimmunitet4 org
7730 t Journal of Internal Medicined : Wileyg 275:2, s. 104-115q 275:2<104-115x 0954-6820x 1365-2796
8564 u https://www.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/joim.12162
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-219274
8564 8u https://doi.org/10.1111/joim.12162
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:128124512

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