Sökning: WFRF:(Helander Herbert F 1935) > The expression of r...
Fältnamn | Indikatorer | Metadata |
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000 | 03914naa a2200349 4500 | |
001 | oai:gup.ub.gu.se/130623 | |
003 | SwePub | |
008 | 240528s2011 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/1306232 URI |
024 | 7 | a https://doi.org/10.1177/14703203103790662 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Hallersund, Peter,d 1975u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning,Institute of Clinical Sciences, Department of Gastrosurgical Research and Education4 aut0 (Swepub:gu)xhpety |
245 | 1 0 | a The expression of renin-angiotensin system components in the human gastric mucosa. |
264 | c 2010-08-25 | |
264 | 1 | b Hindawi Limited,c 2011 |
520 | a INTRODUCTION: : The aim of the present study was to map the distribution of representative protein components of the renin-angiotensin system (RAS) in the human gastric mucosa. MATERIALS AND METHODS: : Biopsies from the antral and corporal mucosa of healthy Helicobacter pylori negative and positive volunteers were assessed by histology, Western blot and immunohistochemistry for angiotensin II subtype 1 and 2 receptors (AT1R, AT2R) and other RAS components (angiotensinogen, renin, angiotensin converting enzyme, and neprilysin). Mucosal levels of myeloperoxidase (MPO) served as a protein marker of neutrophil infiltration. RESULTS: : AT1R and AT2R were located in a variety of cells in the human gastric mucosa, including AT1R on a subpopulation of endocrine cells in the antral mucosa. Angiotensinogen and renin were expressed by resident mesenchymal cells in lamina propria. All investigated RAS components were found in vascular endothelial cells. The AT1R protein expression was 3-4 times higher in the gastric mucosa of H. pylori positive subjects compared to the gastric mucosa of H. pylori negative subjects (p<0.05). Gastric mucosal AT1R protein expression correlated positively with neutrophil infiltration (r=0.7, p<0.05). CONCLUSIONS: : Protein components of RAS are present in the human gastric mucosa. The results suggest an angiotensin II mediated impact on mucosal epithelial functions, antral endocrine properties, microvascular permeability, and gastric inflammation. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng |
653 | a renin-angiotensin | |
653 | a gastric mucosa | |
700 | 1 | a Elfvin, Anders,d 1971u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics4 aut0 (Swepub:gu)xelfan |
700 | 1 | a Helander, Herbert F,d 1935u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning,Institute of Clinical Sciences, Department of Gastrosurgical Research and Education4 aut0 (Swepub:gu)xhelah |
700 | 1 | a Fändriks, Lars,d 1956u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning,Institute of Clinical Sciences, Department of Gastrosurgical Research and Education4 aut0 (Swepub:gu)xfanla |
710 | 2 | a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning4 org |
773 | 0 | t Journal of the renin-angiotensin-aldosterone system : JRAASd : Hindawi Limitedg 12:1, s. 54-64q 12:1<54-64x 1752-8976x 1470-3203 |
856 | 4 | u https://doi.org/10.1177/1470320310379066 |
856 | 4 8 | u https://gup.ub.gu.se/publication/130623 |
856 | 4 8 | u https://doi.org/10.1177/1470320310379066 |
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