Sökning: WFRF:(Holden L) > Predicting the viru...
Fältnamn | Indikatorer | Metadata |
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000 | 04397naa a2200745 4500 | |
001 | oai:gup.ub.gu.se/198744 | |
003 | SwePub | |
008 | 240528s2014 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/1987442 URI |
024 | 7 | a https://doi.org/10.1101/gr.165415.1132 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Laabei, M.4 aut |
245 | 1 0 | a Predicting the virulence of MRSA from its genome sequence |
264 | c 2014-04-09 | |
264 | 1 | b Cold Spring Harbor Laboratory,c 2014 |
338 | a electronic2 rdacarrier | |
520 | a Microbial virulence is a complex and often multifactorial phenotype, intricately linked to a pathogen's evolutionary trajectory. Toxicity, the ability to destroy host cell membranes, and adhesion, the ability to adhere to human tissues, are the major virulence factors of many bacterial pathogens, including Staphylococcus aureus. Here, we assayed the toxicity and adhesiveness of 90 MRSA (methicillin resistant S. aureus) isolates and found that while there was remarkably little variation in adhesion, toxicity varied by over an order of magnitude between isolates, suggesting different evolutionary selection pressures acting on these two traits. We performed a genome-wide association study (GWAS) and identified a large number of loci, as well as a putative network of epistatically interacting loci, that significantly associated with toxicity. Despite this apparent complexity in toxicity regulation, a predictive model based on a set of significant single nucleotide polymorphisms (SNPs) and insertion and deletions events (indels) showed a high degree of accuracy in predicting an isolate's toxicity solely from the genetic signature at these sites. Our results thus highlight the potential of using sequence data to determine clinically relevant parameters and have further implications for understanding the microbial virulence of this opportunistic pathogen. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
653 | a RESISTANT STAPHYLOCOCCUS-AUREUS | |
653 | a MYCOBACTERIUM-TUBERCULOSIS | |
653 | a EVOLUTION | |
653 | a IDENTIFICATION | |
653 | a EXPRESSION | |
653 | a GENE | |
653 | a BIOSYNTHESIS | |
653 | a MICROBIOLOGY | |
653 | a TRANSMISSION | |
700 | 1 | a Recker, M.4 aut |
700 | 1 | a Rudkin, J. K.4 aut |
700 | 1 | a Aldeljawi, M.4 aut |
700 | 1 | a Gulay, Z.4 aut |
700 | 1 | a Sloan, T. J.4 aut |
700 | 1 | a Williams, P.4 aut |
700 | 1 | a Endres, J. L.4 aut |
700 | 1 | a Bayles, K. W.4 aut |
700 | 1 | a Fey, P. D.4 aut |
700 | 1 | a Yajjala, V. K.4 aut |
700 | 1 | a Widhelm, T.4 aut |
700 | 1 | a Hawkins, E.4 aut |
700 | 1 | a Lewis, K.4 aut |
700 | 1 | a Parfett, S.4 aut |
700 | 1 | a Scowen, L.4 aut |
700 | 1 | a Peacock, S. J.4 aut |
700 | 1 | a Holden, M.4 aut |
700 | 1 | a Wilson, D.4 aut |
700 | 1 | a Read, T. D.4 aut |
700 | 1 | a van den Elsen, J.4 aut |
700 | 1 | a Priest, N. K.4 aut |
700 | 1 | a Feil, E. J.4 aut |
700 | 1 | a Hurst, L. D.4 aut |
700 | 1 | a Josefsson, Elisabet,d 1966u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research4 aut0 (Swepub:gu)xjosel |
700 | 1 | a Massey, R. C.4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning4 org |
773 | 0 | t Genome Researchd : Cold Spring Harbor Laboratoryg 24:5, s. 839-849q 24:5<839-849x 1088-9051 |
856 | 4 | u https://gup.ub.gu.se/publication/198744x primaryx freey FULLTEXT |
856 | 4 | u http://genome.cshlp.org/content/24/5/839.full.pdf |
856 | 4 8 | u https://gup.ub.gu.se/publication/198744 |
856 | 4 8 | u https://doi.org/10.1101/gr.165415.113 |
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