Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium

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Fältnamn	Indikatorer	Metadata
000		09866naa a2202185 4500
001		oai:DiVA.org:uu-500376
003		SwePub
008		230415s2023 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:153670733
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5003762 URI
024	7	a https://doi.org/10.1073/pnas.22138801202 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1536707332 URI
040		a (SwePub)uud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Schijven, Dick4 aut
245	1 0	a Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium
264		c 2023-03-28
264	1	b Proceedings of the National Academy of Sciences (PNAS),c 2023
338		a electronic2 rdacarrier
520		a Left-right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting in equivocal findings. We carried out the largest case-control study of structural brain asymmetries in schizophrenia, with MRI data from 5,080 affected individuals and 6,015 controls across 46 datasets, using a single image analysis protocol. Asymmetry indexes were calculated for global and regional cortical thickness, surface area, and subcortical volume measures. Differences of asymmetry were calculated between affected individuals and controls per dataset, and effect sizes were meta-analyzed across datasets. Small average case-control differences were observed for thickness asymmetries of the rostral anterior cingulate and the middle temporal gyrus, both driven by thinner left-hemispheric cortices in schizophrenia. Analyses of these asymmetries with respect to the use of antipsychotic medication and other clinical variables did not show any significant associations. Assessment of age- and sex-specific effects revealed a stronger average leftward asymmetry of pallidum volume between older cases and controls. Case-control differences in a multivariate context were assessed in a subset of the data (N = 2,029), which revealed that 7% of the variance across all structural asymmetries was explained by case-control status. Subtle case-control differences of brain macrostructural asymmetry may reflect differences at the molecular, cytoarchitectonic, or circuit levels that have functional relevance for the disorder. Reduced left middle temporal cortical thickness is consistent with altered left-hemisphere language network organization in schizophrenia.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
653		a Schizophrenia
653		a asymmetry
653		a brain imaging
653		a cortical
653		a subcortical
700	1	a Postema, Merel C.4 aut
700	1	a Fukunaga, Masaki4 aut
700	1	a Matsumoto, Junya4 aut
700	1	a Miura, Kenichiro4 aut
700	1	a de Zwarte, Sonja M. C.4 aut
700	1	a van Haren, Neeltje E. M.4 aut
700	1	a Cahn, Wiepke4 aut
700	1	a Hulshoff Pol, Hilleke E.4 aut
700	1	a Kahn, René S.4 aut
700	1	a Ayesa-Arriola, Rosa4 aut
700	1	a Ortiz-García de la Foz, Víctor4 aut
700	1	a Tordesillas-Gutierrez, Diana4 aut
700	1	a Vázquez-Bourgon, Javier4 aut
700	1	a Crespo-Facorro, Benedicto4 aut
700	1	a Alnæs, Dag4 aut
700	1	a Dahl, Andreas4 aut
700	1	a Westlye, Lars T.4 aut
700	1	a Agartz, Ingrid4 aut
700	1	a Andreassen, Ole A.4 aut
700	1	a Jönsson, Erik G.u Karolinska Institutet4 aut
700	1	a Kochunov, Peter4 aut
700	1	a Bruggemann, Jason M.4 aut
700	1	a Catts, Stanley V.4 aut
700	1	a Michie, Patricia T.4 aut
700	1	a Mowry, Bryan J.4 aut
700	1	a Quidé, Yann4 aut
700	1	a Rasser, Paul E.4 aut
700	1	a Schall, Ulrich4 aut
700	1	a Scott, Rodney J.4 aut
700	1	a Carr, Vaughan J.4 aut
700	1	a Green, Melissa J.4 aut
700	1	a Henskens, Frans A.4 aut
700	1	a Loughland, Carmel M.4 aut
700	1	a Pantelis, Christos4 aut
700	1	a Weickert, Cynthia Shannon4 aut
700	1	a Weickert, Thomas W.4 aut
700	1	a de Haan, Lieuwe4 aut
700	1	a Brosch, Katharina4 aut
700	1	a Pfarr, Julia-Katharina4 aut
700	1	a Ringwald, Kai G.4 aut
700	1	a Stein, Frederike4 aut
700	1	a Jansen, Andreas4 aut
700	1	a Kircher, Tilo T. J.4 aut
700	1	a Nenadić, Igor4 aut
700	1	a Krämer, Bernd4 aut
700	1	a Gruber, Oliver4 aut
700	1	a Satterthwaite, Theodore D.4 aut
700	1	a Bustillo, Juan4 aut
700	1	a Mathalon, Daniel H.4 aut
700	1	a Preda, Adrian4 aut
700	1	a Calhoun, Vince D.4 aut
700	1	a Ford, Judith M.4 aut
700	1	a Potkin, Steven G.4 aut
700	1	a Chen, Jingxu4 aut
700	1	a Tan, Yunlong4 aut
700	1	a Wang, Zhiren4 aut
700	1	a Xiang, Hong4 aut
700	1	a Fan, Fengmei4 aut
700	1	a Bernardoni, Fabio4 aut
700	1	a Ehrlich, Stefan4 aut
700	1	a Fuentes-Claramonte, Paola4 aut
700	1	a Garcia-Leon, Maria Angeles4 aut
700	1	a Guerrero-Pedraza, Amalia4 aut
700	1	a Salvador, Raymond4 aut
700	1	a Sarró, Salvador4 aut
700	1	a Pomarol-Clotet, Edith4 aut
700	1	a Ciullo, Valentina4 aut
700	1	a Piras, Fabrizio4 aut
700	1	a Vecchio, Daniela4 aut
700	1	a Banaj, Nerisa4 aut
700	1	a Spalletta, Gianfranco4 aut
700	1	a Michielse, Stijn4 aut
700	1	a van Amelsvoort, Therese4 aut
700	1	a Dickie, Erin W.4 aut
700	1	a Voineskos, Aristotle N.4 aut
700	1	a Sim, Kang4 aut
700	1	a Ciufolini, Simone4 aut
700	1	a Dazzan, Paola4 aut
700	1	a Murray, Robin M.4 aut
700	1	a Kim, Woo-Sung4 aut
700	1	a Chung, Young-Chul4 aut
700	1	a Andreou, Christina4 aut
700	1	a Schmidt, André4 aut
700	1	a Borgwardt, Stefan4 aut
700	1	a McIntosh, Andrew M.4 aut
700	1	a Whalley, Heather C.4 aut
700	1	a Lawrie, Stephen M.4 aut
700	1	a du Plessis, Stefan4 aut
700	1	a Luckhoff, Hilmar K.4 aut
700	1	a Scheffler, Freda4 aut
700	1	a Emsley, Robin4 aut
700	1	a Grotegerd, Dominik4 aut
700	1	a Lencer, Rebekka4 aut
700	1	a Dannlowski, Udo4 aut
700	1	a Edmond, Jesse T.4 aut
700	1	a Rootes-Murdy, Kelly4 aut
700	1	a Stephen, Julia M.4 aut
700	1	a Mayer, Andrew R.4 aut
700	1	a Antonucci, Linda A.4 aut
700	1	a Fazio, Leonardo4 aut
700	1	a Pergola, Giulio4 aut
700	1	a Bertolino, Alessandro4 aut
700	1	a Díaz-Caneja, Covadonga M.4 aut
700	1	a Janssen, Joost4 aut
700	1	a Lois, Noemi G.4 aut
700	1	a Arango, Celso4 aut
700	1	a Tomyshev, Alexander S.4 aut
700	1	a Lebedeva, Irina4 aut
700	1	a Cervenka, Simonu Uppsala universitet,Psykiatri,Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm 113 64, Sweden4 aut0 (Swepub:uu)simce160
700	1	a Sellgren, Carl M.4 aut
700	1	a Georgiadis, Foivos4 aut
700	1	a Kirschner, Matthias4 aut
700	1	a Kaiser, Stefan4 aut
700	1	a Hajek, Tomas4 aut
700	1	a Skoch, Antonin4 aut
700	1	a Spaniel, Filip4 aut
700	1	a Kim, Minah4 aut
700	1	a Kwak, Yoo Bin4 aut
700	1	a Oh, Sanghoon4 aut
700	1	a Kwon, Jun Soo4 aut
700	1	a James, Anthony4 aut
700	1	a Bakker, Geor4 aut
700	1	a Knöchel, Christian4 aut
700	1	a Stäblein, Michael4 aut
700	1	a Oertel, Viola4 aut
700	1	a Uhlmann, Anne4 aut
700	1	a Howells, Fleur M.4 aut
700	1	a Stein, Dan J.4 aut
700	1	a Temmingh, Henk S.4 aut
700	1	a Diaz-Zuluaga, Ana M.4 aut
700	1	a Pineda-Zapata, Julian A.4 aut
700	1	a López-Jaramillo, Carlos4 aut
700	1	a Homan, Stephanie4 aut
700	1	a Ji, Ellen4 aut
700	1	a Surbeck, Werner4 aut
700	1	a Homan, Philipp4 aut
700	1	a Fisher, Simon E.4 aut
700	1	a Franke, Barbara4 aut
700	1	a Glahn, David C.4 aut
700	1	a Gur, Ruben C.4 aut
700	1	a Hashimoto, Ryota4 aut
700	1	a Jahanshad, Neda4 aut
700	1	a Lueders, Eileenu Uppsala universitet,Reproduktiv hälsa,School of Psychology, University of Auckland, Auckland 1010, New Zealand; Laboratory of Neuro Imaging, School of Medicine, University of Southern California, Los Angeles, CA 900334 aut0 (Swepub:uu)eillu491
700	1	a Medland, Sarah E.4 aut
700	1	a Thompson, Paul M.4 aut
700	1	a Turner, Jessica A.4 aut
700	1	a van Erp, Theo G. M.4 aut
700	1	a Francks, Clyde4 aut
710	2	a Karolinska Institutetb Psykiatri4 org
773	0	t Proceedings of the National Academy of Sciences of the United States of Americad : Proceedings of the National Academy of Sciences (PNAS)g 120:14q 120:14x 0027-8424x 1091-6490
856	4	u https://doi.org/10.1073/pnas.2213880120y Fulltext
856	4	u https://uu.diva-portal.org/smash/get/diva2:1751003/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-500376
856	4 8	u https://doi.org/10.1073/pnas.2213880120
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:153670733

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Av författaren/redakt...: Schijven, Dick; Postema, Merel C ...; Fukunaga, Masaki; Matsumoto, Junya; Miura, Kenichiro; de Zwarte, Sonja ...; visa fler...; van Haren, Neelt ...; Cahn, Wiepke; Hulshoff Pol, Hi ...; Kahn, René S.; Ayesa-Arriola, R ...; Ortiz-García de ...; Tordesillas-Guti ...; Vázquez-Bourgon, ...; Crespo-Facorro, ...; Alnæs, Dag; Dahl, Andreas; Westlye, Lars T.; Agartz, Ingrid; Andreassen, Ole ...; Jönsson, Erik G.; Kochunov, Peter; Bruggemann, Jaso ...; Catts, Stanley V ...; Michie, Patricia ...; Mowry, Bryan J.; Quidé, Yann; Rasser, Paul E.; Schall, Ulrich; Scott, Rodney J.; Carr, Vaughan J.; Green, Melissa J ...; Henskens, Frans ...; Loughland, Carme ...; Pantelis, Christ ...; Weickert, Cynthi ...; Weickert, Thomas ...; de Haan, Lieuwe; Brosch, Katharin ...; Pfarr, Julia-Kat ...; Ringwald, Kai G.; Stein, Frederike; Jansen, Andreas; Kircher, Tilo T. ...; Nenadić, Igor; Krämer, Bernd; Gruber, Oliver; Satterthwaite, T ...; Bustillo, Juan; Mathalon, Daniel ...; Preda, Adrian; Calhoun, Vince D ...; Ford, Judith M.; Potkin, Steven G ...; Chen, Jingxu; Tan, Yunlong; Wang, Zhiren; Xiang, Hong; Fan, Fengmei; Bernardoni, Fabi ...; Ehrlich, Stefan; Fuentes-Claramon ...; Garcia-Leon, Mar ...; Guerrero-Pedraza ...; Salvador, Raymon ...; Sarró, Salvador; Pomarol-Clotet, ...; Ciullo, Valentin ...; Piras, Fabrizio; Vecchio, Daniela; Banaj, Nerisa; Spalletta, Gianf ...; Michielse, Stijn; van Amelsvoort, ...; Dickie, Erin W.; Voineskos, Arist ...; Sim, Kang; Ciufolini, Simon ...; Dazzan, Paola; Murray, Robin M.; Kim, Woo-Sung; Chung, Young-Chu ...; Andreou, Christi ...; Schmidt, André; Borgwardt, Stefa ...; McIntosh, Andrew ...; Whalley, Heather ...; Lawrie, Stephen ...; du Plessis, Stef ...; Luckhoff, Hilmar ...; Scheffler, Freda; Emsley, Robin; Grotegerd, Domin ...; Lencer, Rebekka; Dannlowski, Udo; Edmond, Jesse T.; Rootes-Murdy, Ke ...; Stephen, Julia M ...; Mayer, Andrew R.; Antonucci, Linda ...; Fazio, Leonardo; Pergola, Giulio; Bertolino, Aless ...; Díaz-Caneja, Cov ...; Janssen, Joost; Lois, Noemi G.; Arango, Celso; Tomyshev, Alexan ...; Lebedeva, Irina; Cervenka, Simon; Sellgren, Carl M ...; Georgiadis, Foiv ...; Kirschner, Matth ...; Kaiser, Stefan; Hajek, Tomas; Skoch, Antonin; Spaniel, Filip; Kim, Minah; Kwak, Yoo Bin; Oh, Sanghoon; Kwon, Jun Soo; James, Anthony; Bakker, Geor; Knöchel, Christi ...; Stäblein, Michae ...; Oertel, Viola; Uhlmann, Anne; Howells, Fleur M ...; Stein, Dan J.; Temmingh, Henk S ...; Diaz-Zuluaga, An ...; Pineda-Zapata, J ...; López-Jaramillo, ...; Homan, Stephanie; Ji, Ellen; Surbeck, Werner; Homan, Philipp; Fisher, Simon E.; Franke, Barbara; Glahn, David C.; Gur, Ruben C.; Hashimoto, Ryota; Jahanshad, Neda; Lueders, Eileen; Medland, Sarah E ...; Thompson, Paul M ...; Turner, Jessica ...; van Erp, Theo G. ...; Francks, Clyde; visa färre...

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