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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003241naa a2200409 4500
001oai:lup.lub.lu.se:54cecc7f-fcb5-465b-84a7-19297563e9af
003SwePub
008160401s2011 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/17909932 URI
0247 a https://doi.org/10.1111/j.1365-3083.2010.02485.x2 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Huang, Y. L.4 aut
2451 0a Prevention of Acute and Chronic Allograft Rejection by Combinations of Tolerogenic Dendritic Cells
264 c 2011-01-04
264 1b Wiley,c 2011
520 a It is well known that adoptive transfer of donor-derived tolerogenic dendritic cells (DC) helps to reduce acute allograft rejection. However, this method cannot effectively prevent grafts from infiltration of inflammatory cells and fibrosis, and thus has minimal effect on chronic allograft rejection. In this study, we used mitomycin C (MMC) to generate tolerogenic DC and demonstrated that donor (Balb/c)-derived MMC-DC could induce hyporesponsiveness of recipient (C57BL/6) T cells in vitro, potentially by inducing T-cell apoptosis, decreasing IL-2 and IL-12 secretion, and increasing regulatory T-cell numbers and IL-10 secretion. Furthermore, anti-CD154 monoclonal antibody (mAb) treatment combined with donor-derived MMC-DC prolonged the survival of the allografts in vivo. The mechanisms were similar to those in vitro. Impressively, both acute and chronic rejection were prevented when donor and F1 generation (Balb/c x C57BL/6) derived MMC-DC were injected together with anti-CD154 mAb into recipients before heart allotransplantation. In summary, we showed that donor and F1-derived tolerogenic DC have a synergistic effect on induction and maintenance of T-cell regulation and the secretion of immunosuppressive cytokines. Moreover, adoptive transfer of these two types of DC could inhibit both acute and chronic transplant rejection in mice.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
7001 a Wang, Y. Z.4 aut
7001 a Chen, J. B.4 aut
7001 a Wang, F.4 aut
7001 a Kang, X. P.4 aut
7001 a Xia, J. J.4 aut
7001 a Lan, T. S.4 aut
7001 a Xie, B. Y.4 aut
7001 a Ekberg, Henriku Lund University,Lunds universitet,Enheten för forskning kring njurfunktion och njursjukdom,Kirurgi,Forskargrupper vid Lunds universitet,Renal Research Unit,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)kir-hek
7001 a Wang, X. M.4 aut
7001 a Qi, Z. Q.4 aut
7102 a Enheten för forskning kring njurfunktion och njursjukdomb Kirurgi4 org
7730 t Scandinavian Journal of Immunologyd : Wileyg 73:2, s. 91-101q 73:2<91-101x 1365-3083x 0300-9475
8564 u http://dx.doi.org/10.1111/j.1365-3083.2010.02485.xy FULLTEXT
8564 8u https://lup.lub.lu.se/record/1790993
8564 8u https://doi.org/10.1111/j.1365-3083.2010.02485.x

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