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  • Carter, Jodi M.Univ Alberta, Dept Lab Med & Pathol, Edmonton, AB, Canada. (author)

Distinct spatial immune microlandscapes are independently associated with outcomes in triple-negative breast cancer

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • Springer Nature,2023
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-506591
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-506591URI
  • https://doi.org/10.1038/s41467-023-37806-0DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The utility of spatial immunobiomarker quantitation in prognostication and therapeutic prediction is actively being investigated in triple-negative breast cancer (TNBC). Here, with high-plex quantitative digital spatial profiling, we map and quantitate intraepithelial and adjacent stromal tumor immune protein microenvironments in systemic treatment-naive (female only) TNBC to assess the spatial context in immunobiomarker-based prediction of outcome. Immune protein profiles of CD45-rich and CD68-rich stromal microenvironments differ significantly. While they typically mirror adjacent, intraepithelial microenvironments, this is not uniformly true. In two TNBC cohorts, intraepithelial CD40 or HLA-DR enrichment associates with better outcomes, independently of stromal immune protein profiles or stromal TILs and other established prognostic variables. In contrast, intraepithelial or stromal microenvironment enrichment with IDO1 associates with improved survival irrespective of its spatial location. Antigen-presenting and T-cell activation states are inferred from eigenprotein scores. Such scores within the intraepithelial compartment interact with PD-L1 and IDO1 in ways that suggest prognostic and/or therapeutic potential. This characterization of the intrinsic spatial immunobiology of treatment-naive TNBC highlights the importance of spatial microenvironments for biomarker quantitation to resolve intrinsic prognostic and predictive immune features and ultimately inform therapeutic strategies for clinically actionable immune biomarkers.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Chumsri, SaranyaMayo Clin, Dept Med, Div Hematol & Oncol, Jacksonville, FL USA. (author)
  • Hinerfeld, Douglas A.Ultima Genom, Newark, CA USA. (author)
  • Ma, YaohuaMayo Clin, Dept Hlth Sci Res, Div Biomed Stat & Informat, Jacksonville, FL USA. (author)
  • Wang, XueMayo Clin, Dept Hlth Sci Res, Div Biomed Stat & Informat, Jacksonville, FL USA. (author)
  • Zahrieh, DavidMayo Clin, Dept Hlth Sci Res, Div Biomed Stat & Informat, Rochester, MN USA. (author)
  • Hillman, David W.Mayo Clin, Dept Hlth Sci Res, Div Biomed Stat & Informat, Rochester, MN USA. (author)
  • Tenner, Kathleen S.Mayo Clin, Dept Hlth Sci Res, Div Biomed Stat & Informat, Rochester, MN USA. (author)
  • Kachergus, Jennifer M.Mayo Clin, Dept Canc Biol, Jacksonville, FL 32224 USA. (author)
  • Brauer, Heather AnnBill & Melinda Gates Fdn, Seattle, WA USA. (author)
  • Warren, Sarah E.Kite Pharm, Santa Monica, CA USA. (author)
  • Henderson, DavidNanoString Technol Inc, Seattle, WA USA. (author)
  • Shi, JiMayo Clin, Dept Canc Biol, Jacksonville, FL 32224 USA. (author)
  • Liu, YiMayo Clin, Dept Canc Biol, Jacksonville, FL 32224 USA. (author)
  • Joensuu, HeikkiHelsinki Univ Hosp, Dept Oncol, Helsinki, Finland. (author)
  • Lindman, HenrikUppsala universitet,Institutionen för immunologi, genetik och patologi,Klinisk onkologi(Swepub:uu)henrlind (author)
  • Leon-Ferre, Roberto A. (author)
  • Boughey, Judy C. (author)
  • Liu, Minetta C. (author)
  • Ingle, James N. (author)
  • Kalari, Krishna R.Mayo Clin, Dept Hlth Sci Res, Div Biomed Stat & Informat, Rochester, MN USA. (author)
  • Couch, Fergus J. (author)
  • Knutson, Keith L. (author)
  • Goetz, Matthew P. (author)
  • Perez, Edith A.Mayo Clin, Dept Med, Div Hematol & Oncol, Jacksonville, FL USA. (author)
  • Thompson, E. AubreyMayo Clin, Dept Canc Biol, Jacksonville, FL 32224 USA. (author)
  • Univ Alberta, Dept Lab Med & Pathol, Edmonton, AB, Canada.Mayo Clin, Dept Med, Div Hematol & Oncol, Jacksonville, FL USA. (creator_code:org_t)

Related titles

  • In:Nature Communications: Springer Nature142041-1723

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