Molecular atlas of the adult mouse brain

QC 20200727
Brain maps are essential for integrating information and interpreting the structure-function relationship of circuits and behavior. We aimed to generate a systematic classification of the adult mouse brain based purely on the unbiased identification of spatially defining features by employing whole-brain spatial transcriptomics. We found that the molecular information was sufficient to deduce the complex and detailed neuroanatomical organization of the brain. The unsupervised (non-expert, data-driven) classification revealed new area- and layer-specific subregions, for example in isocortex and hippocampus, and new subdivisions of striatum. The molecular atlas further supports the characterization of the spatial identity of neurons from their single-cell RNA profile, and provides a resource for annotating the brain using a minimal gene set-a brain palette. In summary, we have established a molecular atlas to formally define the spatial organization of brain regions, including the molecular code for mapping and targeting of discrete neuroanatomical domains.

Fernandez Navarro, JoseKTH,Genteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u11gbovc (författare)
Jurek, AleksandraKTH,Genteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1qtfp9v (författare)
Martin, AntjeKarolinska Inst, Dept Neurosci, Stockholm, Sweden. (författare)
Lundeberg, JoakimKTH,Science for Life Laboratory, SciLifeLab,Genteknologi(Swepub:kth)u1qkn9kw (författare)
Meletis, KonstantinosKarolinska Institutet (författare)
Karolinska Inst, Dept Neurosci, Stockholm, Sweden.Genteknologi (creator_code:org_t)

Ingår i:Science Advances: American Association for the Advancement of Science (AAAS)6:262375-2548

Av författaren/redakt...: Ortiz, Cantin; Fernandez Navarr ...; Jurek, Aleksandr ...; Martin, Antje; Lundeberg, Joaki ...; Meletis, Konstan ...

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