WFRF:(Peeters P.H.M.)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 06863naa a2201105 4500 | |
| 001 | oai:gup.ub.gu.se/210477 | |
| 003 | SwePub | |
| 008 | 240528s2015 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:0859d1ef-21ba-4256-b8ce-8fd28d02f727 | |
| 009 | oai:DiVA.org:umu-95217 | |
| 009 | oai:prod.swepub.kib.ki.se:130277440 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2104772 URI |
| 024 | 7 | a https://doi.org/10.1002/ijc.290342 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/49506712 URI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-952172 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1302774402 URI |
| 040 | a (SwePub)gud (SwePub)lud (SwePub)umud (SwePub)ki | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Duell, E. J.4 aut |
| 245 | 1 0 | a Variation at ABO histo-blood group and FUT loci and diffuse and intestinal gastric cancer risk in a European population |
| 264 | c 2014-07-01 | |
| 264 | 1 | b Wiley,c 2015 |
| 520 | a ABO blood serotype A is known to be associated with risk of gastric cancer (GC), but little is known how ABO alleles and the fucosyltransferase (FUT) enzymes and genes which are involved in Lewis antigen formation [and in Helicobacter pylori (H. pylori) binding and pathogenicity] may be related to GC risk in a European population. The authors conducted an investigation of 32 variants at ABO and FUT1-7 loci and GC risk in a case-control study of 365 cases and 1,284 controls nested within the EPIC cohort (the EPIC-Eurgast study). Four variants (including rs505922) in ABO, and allelic blood group A (AO+AA, odds ratio=1.84, 95%CI=1.20-2.80) were associated with diffuse-type GC; however, conditional models with other ABO variants indicated that the associations were largely due to allelic blood group A. One variant in FUT5 was also associated with diffuse-type GC, and four variants (and haplotypes) in FUT2 (Se), FUT3 (Le) and FUT6 with intestinal-type GC. Further, one variant in ABO, two in FUT3 and two in FUT6 were associated with H. pylori infection status in controls, and two of these (in FUT3 and FUT6) were weakly associated with intestinal-type GC risk. None of the individual variants surpassed a Bonferroni corrected p-value cutoff of 0.0016; however, after a gene-based permutation test, two loci [FUT3(Le)/FUT5/FUT6 and FUT2(Se)] were significantly associated with diffuse- and intestinal-type GC, respectively. Replication and functional studies are therefore recommended to clarify the role of ABO and FUT alleles in H. pylori infection and subtype-specific gastric carcinogenesis. What's New? Blood type A indicates a higher risk of gastric cancer, but why? This study examined the relationship between blood group genes and cancer. The authors investigated 32 variants among not only the ABO alleles, but also including the genes involved in producing the Lewis blood group antigens. They confirmed blood group A as a risk factor for diffuse-type gastric cancer, and also detected an association between certain Lewis antigen alleles and intestinal-type gastric cancer. Interestingly, these alleles also popped up among controls who harbored H. pylori infection. These associations certainly warrant further investigation into their role in gastric cancer. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 653 | a gastric cancer | |
| 653 | a blood group | |
| 653 | a ABO | |
| 653 | a FUT | |
| 653 | a genetic susceptibility | |
| 653 | a HELICOBACTER-PYLORI INFECTION | |
| 653 | a ANTIGEN-BINDING ADHESIN | |
| 653 | a GENOME-WIDE | |
| 653 | a ASSOCIATION | |
| 653 | a PANCREATIC-CANCER | |
| 653 | a COHORT CONSORTIUM | |
| 653 | a LEWIS ANTIGENS | |
| 653 | a GROUP | |
| 653 | a ALLELES | |
| 653 | a EXPRESSION | |
| 653 | a VITAMIN-B-12 | |
| 653 | a METAANALYSIS | |
| 653 | a Oncology | |
| 700 | 1 | a Bonet, C.4 aut |
| 700 | 1 | a Munoz, X.4 aut |
| 700 | 1 | a Lujan-Barroso, L.4 aut |
| 700 | 1 | a Weiderpass, E.u Karolinska Institutet4 aut |
| 700 | 1 | a Boutron-Ruault, M. C.4 aut |
| 700 | 1 | a Racine, A.4 aut |
| 700 | 1 | a Severi, G.4 aut |
| 700 | 1 | a Canzian, F.4 aut |
| 700 | 1 | a Rizzato, C.4 aut |
| 700 | 1 | a Boeing, H.4 aut |
| 700 | 1 | a Overvad, K.4 aut |
| 700 | 1 | a Tjonneland, A.4 aut |
| 700 | 1 | a Arguelles, M.4 aut |
| 700 | 1 | a Sanchez-Cantalejo, E.4 aut |
| 700 | 1 | a Chamosa, S.4 aut |
| 700 | 1 | a Huerta, J. M.u Umeå universitet,Enheten för biobanksforskning4 aut |
| 700 | 1 | a Barricarte, A.4 aut |
| 700 | 1 | a Khaw, K. T.4 aut |
| 700 | 1 | a Wareham, N.4 aut |
| 700 | 1 | a Travis, R. C.4 aut |
| 700 | 1 | a Trichopoulou, A.4 aut |
| 700 | 1 | a Trichopoulos, D.4 aut |
| 700 | 1 | a Yiannakouris, N.4 aut |
| 700 | 1 | a Palli, D.4 aut |
| 700 | 1 | a Agnoli, C.4 aut |
| 700 | 1 | a Tumino, R.4 aut |
| 700 | 1 | a Naccarati, A.4 aut |
| 700 | 1 | a Panico, S.4 aut |
| 700 | 1 | a Bueno-de-Mesquita, H. B.4 aut |
| 700 | 1 | a Siersema, P. D.4 aut |
| 700 | 1 | a Peeters, P. H. M.4 aut |
| 700 | 1 | a Ohlsson, Bodilu Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)kir-boh |
| 700 | 1 | a Lindkvist, Björnu Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine4 aut0 (Swepub:gu)xlibjo |
| 700 | 1 | a Johansson, Ingegerdu Umeå universitet,Enheten för biobanksforskning,Näringsforskning,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden4 aut0 (Swepub:umu)injo0003 |
| 700 | 1 | a Ye, W. M.u Karolinska Institutet,Umeå universitet,Enheten för biobanksforskning,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden4 aut |
| 700 | 1 | a Johansson, M.4 aut |
| 700 | 1 | a Fenger, C.4 aut |
| 700 | 1 | a Riboli, E.4 aut |
| 700 | 1 | a Sala, N.4 aut |
| 700 | 1 | a Gonzalez, C. A.4 aut |
| 710 | 2 | a Karolinska Institutetb Enheten för biobanksforskning4 org |
| 773 | 0 | t International Journal of Cancerd : Wileyg 136:4, s. 880-893q 136:4<880-893x 0020-7136x 1097-0215 |
| 856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.29034 |
| 856 | 4 | u http://dx.doi.org/10.1002/ijc.29034y FULLTEXT |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/210477 |
| 856 | 4 8 | u https://doi.org/10.1002/ijc.29034 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/4950671 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-95217 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:130277440 |
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