LC-QTOF/MS metabolomic profiles in human plasma after a 5-week high dietary fiber intake.

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Fältnamn	Indikatorer	Metadata
000		03634naa a2200337 4500
001		oai:lup.lub.lu.se:1190b4b6-97be-473f-8bbd-58fa068bebb3
003		SwePub
008		160401s2013 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/36276022 URI
024	7	a https://doi.org/10.1007/s00216-013-6874-52 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Johansson Persson, Annau Lund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)tbio-ajo
245	1 0	a LC-QTOF/MS metabolomic profiles in human plasma after a 5-week high dietary fiber intake.
264		c 2013-03-28
264	1	b Springer Science and Business Media LLC,c 2013
520		a The objective was to investigate the alterations of plasma metabolome profiles to identify exposure and effect markers of dietary fiber intake. Subjects (n = 25) aged 58.6 (1.1) years (mean and SD) with a body mass index of 26.6 (0.5) kg/m(2) were given a high fiber (HF) and a low fiber (LF) diet, in a 5-week randomized controlled crossover intervention. The HF diet consisted of oat bran, rye bran, and sugar beet fiber incorporated into test food products, whereas the LF diet was made of equivalent food products to the HF diet, but without adding fibers. Blood plasma samples were collected at the start and end of each intervention period and analyzed by LC-QTOF/MS. In total, 6 features in positive mode and 14 features in negative mode were significantly different between the HF and the LF diet (p < 0.01, q < 0.05). Two markers, 2,6-dihydroxybenzoic acid and 2-aminophenol sulfate, were increased after HF diet, along with a tentatively identified saponin derived from oat avenacosides. The untargeted metabolomics approach enabled the identification of two new markers of dietary fiber intake in human plasma. Further studies will be needed to verify if these markers could serve as compliance markers of fiber intake.
650	7	a NATURVETENSKAPx Kemix Analytisk kemi0 (SwePub)104012 hsv//swe
650	7	a NATURAL SCIENCESx Chemical Sciencesx Analytical Chemistry0 (SwePub)104012 hsv//eng
700	1	a Barri, Thaer4 aut
700	1	a Ulmius, Matildau Lund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)kcx-mui
700	1	a Önning, Gunillau Lund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)inl-gon
700	1	a Dragsted, Lars Ove4 aut
710	2	a Tillämpad biokemib Centrum för tillämpade biovetenskaper4 org
773	0	t Analytical and Bioanalytical Chemistryd : Springer Science and Business Media LLCg 405:14, s. 4799-4809q 405:14<4799-4809x 1618-2642x 1618-2650
856	4	u http://dx.doi.org/10.1007/s00216-013-6874-5y FULLTEXT
856	4 8	u https://lup.lub.lu.se/record/3627602
856	4 8	u https://doi.org/10.1007/s00216-013-6874-5

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Av författaren/redakt...: Johansson Persso ...; Barri, Thaer; Ulmius, Matilda; Önning, Gunilla; Dragsted, Lars O ...

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