Sökning: WFRF:(Rydell Andreas) >
Cardiovascular dise...
Cardiovascular disease-linked plasma proteins are mainly associated with lung volume
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- Rydell, Andreas (författare)
- Karolinska Institutet,Karolinska Institute
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- Nerpin, Elisabet, 1962- (författare)
- Dalarna University College,Högskolan Dalarna,Uppsala universitet,Lung- allergi- och sömnforskning,School of Health and Welfare, Dalarna University,Medicinsk vetenskap,Uppsala University, Uppsala
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- Zhou, Xingwu (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala University, Uppsala
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- Lind, Lars (författare)
- Uppsala universitet,Klinisk epidemiologi,Uppsala University, Uppsala
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- Lindberg, Eva (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning,Uppsala University, Uppsala
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- Theorell-Haglöw, Jenny (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning,Uppsala University, Uppsala
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- Fall, Tove, 1979- (författare)
- Uppsala universitet,Molekylär epidemiologi,Uppsala University, Uppsala
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- Janson, Christer (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning,Uppsala University, Uppsala
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- Lisspers, Karin, Docent, 1954- (författare)
- Uppsala universitet,Allmänmedicin och preventivmedicin,Uppsala University, Uppsala
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- Elmståhl, Sölve (författare)
- Lund University,Lunds universitet,Geriatrik,Forskargrupper vid Lunds universitet,Geriatrics,Lund University Research Groups
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- Zaigham, Suneela (författare)
- Lund University,Lunds universitet,Uppsala universitet,Klinisk fysiologi,Department of Clinical Sciences, Lund University,Uppsala University, Uppsala; Lund University, Malmö,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
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- Melander, Olle (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital
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- Nilsson, Peter M. (författare)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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- Ärnlöv, Johan, 1970- (författare)
- Karolinska Institute,Dalarna University College,Högskolan Dalarna,Medicinsk vetenskap,Karolinska Institutet, Huddinge; Region Dalarna, Falun
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- Malinovschi, Andrei, 1978- (författare)
- Uppsala universitet,Klinisk fysiologi,Uppsala University, Uppsala
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(creator_code:org_t)
- 2023-01-26
- 2023
- Engelska.
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Ingår i: ERJ Open Research. - : European Respiratory Society. - 2312-0541. ; 9:2
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://du.diva-port... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Epidemiological studies have shown that impaired lung function is common and associated with increased risk of cardiovascular disease. Increased levels of several inflammatory and cardiovascular disease-related plasma proteins have been associated with impaired lung function. The aim was to study the association between plasma proteomics and forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC ratio.METHODS: We used a discovery and replication approach in two community-based cohorts, EpiHealth and the Malmö Offspring Study (total n=2874), to cross-sectionally study 242 cardiovascular disease- and metabolism-linked proteins in relation to FEV1, FVC (both % predicted) and FEV1/FVC ratio. A false discovery rate of 5% was used as the significance threshold in the discovery cohort.RESULTS: Plasma fatty acid-binding protein 4, interleukin-1 receptor antagonist, interleukin-6 and leptin were negatively associated with FEV1 and paraoxonase 3 was positively associated therewith. Fatty acid-binding protein 4, fibroblast growth factor 21, interleukin-1 receptor antagonist, interleukin-6 and leptin were negatively associated with FVC and agouti-related protein, insulin-like growth factor-binding protein 2, paraoxonase 3 and receptor for advanced glycation end products were positively associated therewith. No proteins were associated with FEV1/FVC ratio. A sensitivity analysis in EpiHealth revealed only minor changes after excluding individuals with known cardiovascular disease, diabetes or obesity.CONCLUSIONS: Five proteins were associated with both FEV1 and FVC. Four proteins associated with only FVC and none with FEV1/FVC ratio, suggesting associations mainly through lung volume, not airway obstruction. However, additional studies are needed to investigate underlying mechanisms for these findings.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Lung Medicine
- Lungmedicin
- Physiology
- Fysiologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Rydell, Andreas
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Nerpin, Elisabet ...
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Zhou, Xingwu
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Lind, Lars
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Lindberg, Eva
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Theorell-Haglöw, ...
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visa fler...
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Fall, Tove, 1979 ...
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Janson, Christer
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Lisspers, Karin, ...
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Elmståhl, Sölve
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Zaigham, Suneela
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Melander, Olle
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Nilsson, Peter M ...
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Ärnlöv, Johan, 1 ...
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Malinovschi, And ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Lungmedicin och ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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ERJ Open Researc ...
- Av lärosätet
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Uppsala universitet
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Högskolan Dalarna
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Lunds universitet
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Karolinska Institutet