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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003429naa a2200469 4500
001oai:lup.lub.lu.se:26d23eb2-c51e-4015-a89f-85f618287cce
003SwePub
008160401s2012 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/32762532 URI
0247 a https://doi.org/10.1016/j.fct.2012.04.0192 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a for2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Belsito, D.4 aut
2451 0a A toxicologic and dermatologic assessment of cyclopentanones and cyclopentenones when used as fragrance ingredients
264 1b Elsevier BV,c 2012
520 a The cyclopentanone and cyclopentenone group of fragrance ingredients was critically evaluated for safety following a complete literature search. For high end users, calculated maximum dermal exposures vary from 0.002% to 15.16% in hydroalcoholic products; systemic exposures vary from 0.0003 to 0.7122 mg/kg/day. The cyclopentanones and cyclopentenones had a low order of acute toxicity and no significant toxicity in repeat dose studies. No mutagenic or genotoxic activity in bacteria and mammalian cell line assays was observed. Developmental toxicity was not observed. Minimal evidence of skin irritation in humans is associated with current levels of use. Eleven materials were tested undiluted for eye irritation; three were considered irritants. No phototoxic and photosensitization reactions were seen with nine materials tested. At concentrations higher than current reported use, 14 materials were non-sensitizing in HRIPT or maximization tests. 2-Hexylidene cyclopentanone, 2-heptylidenecyclopentan-1-one and 3-methyl-2-(pentyloxy)-2-cyclopenten-1-one are weak sensitizers and have IFRA Standards. Risk of sensitization to the cyclopentanones and cyclopentenones is generally small under current levels of use. The Panel is of the opinion that there are no safety concerns for the cyclopentanones and cyclopentenones at reported levels of use and exposure as fragrance ingredients. (C) 2012 Elsevier Ltd. All rights reserved.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng
653 a Fragrance material
653 a Group summary
653 a Ketones
653 a Cyclopentanones
653 a Cyclopentenones
653 a Review
7001 a Bickers, D.4 aut
7001 a Bruze, Magnusu Lund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups4 aut0 (Swepub:lu)derm-mbr
7001 a Calow, P.4 aut
7001 a Dagli, M. L.4 aut
7001 a Dekant, W.4 aut
7001 a Fryer, A. D.4 aut
7001 a Greim, H.4 aut
7001 a Miyachi, Y.4 aut
7001 a Saurat, J. H.4 aut
7001 a Sipes, I. G.4 aut
7102 a Yrkes- och miljödermatologib Forskargrupper vid Lunds universitet4 org
7730 t Food and Chemical Toxicologyd : Elsevier BVg 50, s. 517-556q 50<517-556x 0278-6915
8564 u http://dx.doi.org/10.1016/j.fct.2012.04.019y FULLTEXT
8564 8u https://lup.lub.lu.se/record/3276253
8564 8u https://doi.org/10.1016/j.fct.2012.04.019

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