Evolution of pathogenicity and sexual reproduction in eight Candida genomes.

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Fältnamn	Indikatorer	Metadata
000		03954naa a2200865 4500
001		oai:DiVA.org:uu-157849
003		SwePub
008		110823s2009 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1578492 URI
024	7	a https://doi.org/10.1038/nature080642 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Butler, Geraldine4 aut
245	1 0	a Evolution of pathogenicity and sexual reproduction in eight Candida genomes.
264		c 2009-05-24
264	1	b Springer Science and Business Media LLC,c 2009
338		a print2 rdacarrier
520		a Candida species are the most common cause of opportunistic fungal infection worldwide. Here we report the genome sequences of six Candida species and compare these and related pathogens and non-pathogens. There are significant expansions of cell wall, secreted and transporter gene families in pathogenic species, suggesting adaptations associated with virulence. Large genomic tracts are homozygous in three diploid species, possibly resulting from recent recombination events. Surprisingly, key components of the mating and meiosis pathways are missing from several species. These include major differences at the mating-type loci (MTL); Lodderomyces elongisporus lacks MTL, and components of the a1/2 cell identity determinant were lost in other species, raising questions about how mating and cell types are controlled. Analysis of the CUG leucine-to-serine genetic-code change reveals that 99% of ancestral CUG codons were erased and new ones arose elsewhere. Lastly, we revise the Candida albicans gene catalogue, identifying many new genes.
700	1	a Rasmussen, Matthew D4 aut
700	1	a Lin, Michael F4 aut
700	1	a Santos, Manuel A S4 aut
700	1	a Sakthikumar, Sharadha4 aut
700	1	a Munro, Carol A4 aut
700	1	a Rheinbay, Esther4 aut
700	1	a Grabherr, Manfred4 aut
700	1	a Forche, Anja4 aut
700	1	a Reedy, Jennifer L4 aut
700	1	a Agrafioti, Ino4 aut
700	1	a Arnaud, Martha B4 aut
700	1	a Bates, Steven4 aut
700	1	a Brown, Alistair J P4 aut
700	1	a Brunke, Sascha4 aut
700	1	a Costanzo, Maria C4 aut
700	1	a Fitzpatrick, David A4 aut
700	1	a de Groot, Piet W J4 aut
700	1	a Harris, David4 aut
700	1	a Hoyer, Lois L4 aut
700	1	a Hube, Bernhard4 aut
700	1	a Klis, Frans M4 aut
700	1	a Kodira, Chinnappa4 aut
700	1	a Lennard, Nicola4 aut
700	1	a Logue, Mary E4 aut
700	1	a Martin, Ronny4 aut
700	1	a Neiman, Aaron M4 aut
700	1	a Nikolaou, Elissavet4 aut
700	1	a Quail, Michael A4 aut
700	1	a Quinn, Janet4 aut
700	1	a Santos, Maria C4 aut
700	1	a Schmitzberger, Florian F4 aut
700	1	a Sherlock, Gavin4 aut
700	1	a Shah, Prachi4 aut
700	1	a Silverstein, Kevin A T4 aut
700	1	a Skrzypek, Marek S4 aut
700	1	a Soll, David4 aut
700	1	a Staggs, Rodney4 aut
700	1	a Stansfield, Ian4 aut
700	1	a Stumpf, Michael P H4 aut
700	1	a Sudbery, Peter E4 aut
700	1	a Srikantha, Thyagarajan4 aut
700	1	a Zeng, Qiandong4 aut
700	1	a Berman, Judith4 aut
700	1	a Berriman, Matthew4 aut
700	1	a Heitman, Joseph4 aut
700	1	a Gow, Neil A R4 aut
700	1	a Lorenz, Michael C4 aut
700	1	a Birren, Bruce W4 aut
700	1	a Kellis, Manolis4 aut
700	1	a Cuomo, Christina A4 aut
773	0	t Natured : Springer Science and Business Media LLCg 459:7247, s. 657-62q 459:7247<657-62x 1476-4687x 0028-0836
856	4	u https://www.nature.com/articles/nature08064.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-157849
856	4 8	u https://doi.org/10.1038/nature08064

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Av författaren/redakt...: Butler, Geraldin ...; Rasmussen, Matth ...; Lin, Michael F; Santos, Manuel A ...; Sakthikumar, Sha ...; Munro, Carol A; visa fler...; Rheinbay, Esther; Grabherr, Manfre ...; Forche, Anja; Reedy, Jennifer ...; Agrafioti, Ino; Arnaud, Martha B; Bates, Steven; Brown, Alistair ...; Brunke, Sascha; Costanzo, Maria ...; Fitzpatrick, Dav ...; de Groot, Piet W ...; Harris, David; Hoyer, Lois L; Hube, Bernhard; Klis, Frans M; Kodira, Chinnapp ...; Lennard, Nicola; Logue, Mary E; Martin, Ronny; Neiman, Aaron M; Nikolaou, Elissa ...; Quail, Michael A; Quinn, Janet; Santos, Maria C; Schmitzberger, F ...; Sherlock, Gavin; Shah, Prachi; Silverstein, Kev ...; Skrzypek, Marek ...; Soll, David; Staggs, Rodney; Stansfield, Ian; Stumpf, Michael ...; Sudbery, Peter E; Srikantha, Thyag ...; Zeng, Qiandong; Berman, Judith; Berriman, Matthe ...; Heitman, Joseph; Gow, Neil A R; Lorenz, Michael ...; Birren, Bruce W; Kellis, Manolis; Cuomo, Christina ...; visa färre...

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