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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005616naa a2200613 4500
001oai:gup.ub.gu.se/104974
003SwePub
008240528s2009 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:2b2194b6-312f-418f-adcc-fd1a9d95beda
009oai:prod.swepub.kib.ki.se:118977926
0247 a https://gup.ub.gu.se/publication/1049742 URI
0247 a https://lup.lub.lu.se/record/12886362 URI
0247 a https://doi.org/10.1093/ndt/gfn7432 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1189779262 URI
040 a (SwePub)gud (SwePub)lud (SwePub)ki
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Nyström, Jenny,d 1972u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xnysje
2451 0a CRIM1 is localized to the podocyte filtration slit diaphragm of the adult human kidney
264 1b Oxford University Press (OUP),c 2009
520 a BACKGROUND: CRIM1 is a plasma membrane bound protein containing six cysteine-rich repeats (CRR). Through these, CRIM1 has been shown to interact with a subgroup of the TGF-beta superfamily, the bone morphogenic proteins (BMP) isoforms 2, 4 and 7. The probable action is to modulate the signalling properties of these factors. CRIM1 has also been shown to regulate the release of VEGFA by podocytes during renal organogenesis. Knock-out studies in mice have shown that CRIM1 is critically involved in the development of the central nervous system, eye and kidney. Replacement of CRIM1 with a defective version leads to renal dysgenesis and perinatal death. We have analysed the distribution of CRIM1 in adult human renal tissue. METHODS: To this end, we have used immunofluorescence, immunohistochemistry and immunoelectron microscopy. We performed western blotting for the CRIM1 protein, using lysates from isolated glomerular podocytes and human renal tissue homogenate. By using quantitative PCR, we compared the CRIM1 mRNA levels in podocytes, human renal tissue homogenate, primary human renal proximal tubular epithelial cells and primary human pulmonary artery smooth muscle cells. RESULTS: The results show that in the human adult kidney, CRIM1 is mainly expressed in the glomerular podocytes and is associated with the insertional region of the filtration slit diaphragm (SD) of the podocyte pedicles. CONCLUSIONS: CRIM1 is a protein that should be added to the list of proteins associated with the podocyte filtration SD and with the probable action of modulating BMP and VEGFA signalling.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng
653 a Adult
653 a Cells
653 a Cultured
653 a Humans
653 a Kidney/*chemistry
653 a Membrane Proteins/*analysis
653 a Podocytes/*chemistry
653 a podocyte
653 a immunoelectron microscopy
653 a bone morphogenic protein
653 a filtration slit membrane
7001 a Hultenby, K.u Karolinska Institutet4 aut
7001 a Ek, Sarau Lund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)immt-san
7001 a Sjölund, Jonasu Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine4 aut0 (Swepub:lu)molm-sjo
7001 a Axelson, Håkanu Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine4 aut0 (Swepub:lu)molm-hax
7001 a Jirström, Karinu Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)pat-kji
7001 a Saleem, M. A.4 aut
7001 a Nilsson, Kristinau Lund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)pat-kn0
7001 a Johansson, Martinu Lund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)med-mim
7102 a Göteborgs universitetb Institutionen för medicin, avdelningen för molekylär och klinisk medicin4 org
7730 t Nephrol Dial Transplantd : Oxford University Press (OUP)g 24:7, s. 2038-44q 24:7<2038-44x 1460-2385x 1460-2385x 0931-0509
8564 u http://dx.doi.org/10.1093/ndt/gfn743x freey FULLTEXT
8564 u https://academic.oup.com/ndt/article-pdf/24/7/2038/12806623/gfn743.pdf
8564 8u https://gup.ub.gu.se/publication/104974
8564 8u https://lup.lub.lu.se/record/1288636
8564 8u https://doi.org/10.1093/ndt/gfn743
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:118977926

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