An epidemiological perspective on heart and lung weight in cardiac and intoxication deaths

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Beer, Torfinn,1992-Umeå universitet,Rättsmedicin (författare)

An epidemiological perspective on heart and lung weight in cardiac and intoxication deaths

BokEngelska2022

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Umeå :Umeå universitet,2022
51 s.
electronicrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:umu-200631
ISBN:9789178558445
ISBN:9789178558452
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-200631URI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:vet swepub-contenttype
Ämneskategori:dok swepub-publicationtype

Serie

Umeå University medical dissertations,0346-6612 ;2196

Anmärkningar

The main purpose of a medico-legal autopsy is to determine the cause and manner of death. A forensic pathologist makes assessments of this using several sources of information, one of which is the discrepancy between measured organ weight and reference values. Of particular interest is the heart weight in heart disease and the weight of the lungs in fatal intoxications. In this thesis, a linear model of lung weight was created, but the model could at best explain only 13% of the variation in combined lung weight (Paper I). Unsurprisingly, this meant that the model was a poor definition of “normal” lung weight and could not be used to identify intoxication cases (Paper II). A ratio of lung weight to heart weight (LWHW ratio) also failed to differentiate intoxication cases from controls. The poor performance of these methods could plausibly have been due to fatal intoxications with only some substances being associated with increased lung weight, but an analysis showed that many common intoxicants were associated with heavier lungs than hanging deaths (Paper III). To establish heart weight references more applicable in a medico-legal autopsy population, a model of heart weight accounting for undiagnosed cardiac hypertrophy was created (Paper IV). The model showed that for a decedent of average the evidence that a was hypertrophic reached, substantial support at around 470 g.In conclusion, a definition of “heavy lungs” remains elusive. However, it seems to be a finding compatible with fatal intoxications with many substances and the low predictive value found may be due to study design. The heart weight model presented allows pathologists to assess the evidence of cardiac hypertrophy more easily than previously published models.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Annan medicin och hälsovetenskap Rättsmedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Other Medical and Health Sciences Forensic Science hsv//eng
heart weight
lung weight
organ weight
autopsy
forensic pathology
Bayesian analysis
cardiac hypertrophy
fatal intoxication
Forensic Medicine
rättsmedicin

Biuppslag (personer, institutioner, konferenser, titlar ...)

Wingren, Carl Johan,LektorLunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Rättsmedicin (preses)
Eriksson, Anders,ProfessorUmeå universitet,Rättsmedicin(Swepub:umu)aner0001 (preses)
Stålnacke, Britt-Marie,Professor,1955-Umeå universitet,Rehabiliteringsmedicin,Umeå centrum för genusstudier (UCGS)(Swepub:umu)brst0005 (preses)
Molina, Kimberly,Adjunct professorLong School of Medicine, department of pathology and laboratory medicine, University of Texas Medical School, San Antonio, Texas, USA (opponent)
Umeå universitetRättsmedicin (creator_code:org_t)

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Av författaren/redakt...: Beer, Torfinn, 1 ...; Wingren, Carl Jo ...; Eriksson, Anders ...; Stålnacke, Britt ...; Molina, Kimberly ...

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