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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 13265naa a2202005 4500 | |
| 001 | oai:gup.ub.gu.se/296905 | |
| 003 | SwePub | |
| 008 | 240528s2020 | |||||||||||000 ||eng| | |
| 009 | oai:research.chalmers.se:1f87ae7f-9e41-4354-a933-0442c43424f3 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2969052 URI |
| 024 | 7 | a https://doi.org/10.1038/s41586-020-2269-x2 DOI |
| 024 | 7 | a https://research.chalmers.se/publication/5173572 URI |
| 040 | a (SwePub)gud (SwePub)cth | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Vieira-Silva, S.u Katholieke Universiteit Leuven,European Molecular Biology Laboratory4 aut |
| 245 | 1 0 | a Statin therapy is associated with lower prevalence of gut microbiota dysbiosis |
| 264 | c 2020-05-06 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2020 |
| 520 | a Microbiome community typing analyses have recently identified the Bacteroides2 (Bact2) enterotype, an intestinal microbiota configuration that is associated with systemic inflammation and has a high prevalence in loose stools in humans1,2. Bact2 is characterized by a high proportion of Bacteroides, a low proportion of Faecalibacterium and low microbial cell densities1,2, and its prevalence varies from 13% in a general population cohort to as high as 78% in patients with inflammatory bowel disease2. Reported changes in stool consistency3 and inflammation status4 during the progression towards obesity and metabolic comorbidities led us to propose that these developments might similarly correlate with an increased prevalence of the potentially dysbiotic Bact2 enterotype. Here, by exploring obesity-associated microbiota alterations in the quantitative faecal metagenomes of the cross-sectional MetaCardis Body Mass Index Spectrum cohort (n=888), we identify statin therapy as a key covariate of microbiome diversification. By focusing on a subcohort of participants that are not medicated with statins, we find that the prevalence of Bact2 correlates with body mass index, increasing from 3.90% in lean or overweight participants to 17.73% in obese participants. Systemic inflammation levels in Bact2-enterotyped individuals are higher than predicted on the basis of their obesity status, indicative of Bact2 as a dysbiotic microbiome constellation. We also observe that obesity-associated microbiota dysbiosis is negatively associated with statin treatment, resulting in a lower Bact2 prevalence of 5.88% in statin-medicated obese participants. This finding is validated in both the accompanying MetaCardis cardiovascular disease dataset (n = 282) and the independent Flemish Gut Flora Project population cohort (n=2,345). The potential benefits of statins in this context will require further evaluation in a prospective clinical trial to ascertain whether the effect is reproducible in a randomized population and before considering their application as microbiota-modulating therapeutics. © 2020, The Author(s), under exclusive licence to Springer Nature Limited. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 650 | 7 | a NATURVETENSKAPx Biologix Bioinformatik och systembiologi0 (SwePub)106102 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Bioinformatics and Systems Biology0 (SwePub)106102 hsv//eng |
| 653 | a hydroxymethylglutaryl coenzyme A reductase inhibitor | |
| 653 | a bacterium | |
| 653 | a cell | |
| 653 | a digestive system | |
| 653 | a disease prevalence | |
| 653 | a microbial community | |
| 653 | a Article | |
| 653 | a bacterial count | |
| 653 | a bacterium identification | |
| 653 | a Bacteroides | |
| 653 | a body mass | |
| 653 | a cell density | |
| 653 | a comorbidity | |
| 653 | a correlation analysis | |
| 653 | a dysbiosis | |
| 653 | a Faecalibacterium | |
| 653 | a feces analysis | |
| 653 | a human | |
| 653 | a hypercholesterolemia | |
| 653 | a inflammation | |
| 653 | a inflammatory bowel disease | |
| 653 | a intestine flora | |
| 653 | a metabolic disorder | |
| 653 | a metagenome | |
| 653 | a nonhuman | |
| 653 | a obesity | |
| 653 | a prediction | |
| 653 | a prevalence | |
| 653 | a priority journal | |
| 653 | a quantitative analysis | |
| 653 | a species diversity | |
| 700 | 1 | a Falony, G.u Katholieke Universiteit Leuven4 aut |
| 700 | 1 | a Belda, E.4 aut |
| 700 | 1 | a Nielsen, T.u Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Aron-Wisnewsky, J.u Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Chakaroun, R.u Universität Leipzig,Leipzig University4 aut |
| 700 | 1 | a Forslund, S. K.u Max Delbrueck Centrum Fuer Molekulare Medizin,The Max Delbrück Center for Molecular Medicine4 aut |
| 700 | 1 | a Assmann, K.4 aut |
| 700 | 1 | a Valles-Colomer, M.u Katholieke Universiteit Leuven,Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Nguyen, T. T. D.u Katholieke Universiteit Leuven4 aut |
| 700 | 1 | a Proost, S.u Katholieke Universiteit Leuven4 aut |
| 700 | 1 | a Prifti, E.4 aut |
| 700 | 1 | a Tremaroli, Valentina,d 1978u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xtreva |
| 700 | 1 | a Pons, N.u Université Paris-Saclay,University Paris-Saclay4 aut |
| 700 | 1 | a Le Chatelier, E.u Université Paris-Saclay,University Paris-Saclay4 aut |
| 700 | 1 | a Andreelli, F.4 aut |
| 700 | 1 | a Bastard, J. P.u Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Coelho, L. P.u European Molecular Biology Laboratory,Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Galleron, N.u Université Paris-Saclay,University Paris-Saclay4 aut |
| 700 | 1 | a Hansen, T. H.u Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Hulot, J. S.u Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Lewinter, C.u Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Pedersen, H. K.u Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Quinquis, B.u Université Paris-Saclay,University Paris-Saclay4 aut |
| 700 | 1 | a Rouault, C.4 aut |
| 700 | 1 | a Roume, H.u Université Paris-Saclay,University Paris-Saclay4 aut |
| 700 | 1 | a Salem, J. E.u Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Søndertoft, N. B.u Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Touch, S.4 aut |
| 700 | 1 | a Alves, R.u European Molecular Biology Laboratory4 aut |
| 700 | 1 | a Amouyal, C.4 aut |
| 700 | 1 | a Galijatovic, E. A. A.u Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Barthelemy, O.u Assistance publique – Hôpitaux de Paris (AP-HP),Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Batisse, J. P.u Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Berland, M.u Université Paris-Saclay,University Paris-Saclay4 aut |
| 700 | 1 | a Bittar, R.u Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Blottière, H.u Université Paris-Saclay,University Paris-Saclay4 aut |
| 700 | 1 | a Bosquet, F.u Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Boubrit, R.u Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Bourron, O.u Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Camus, M.u Université Paris-Saclay,University Paris-Saclay4 aut |
| 700 | 1 | a Cassuto, D.u Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Ciangura, C.u Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Collet, J. P.u Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Dao, M. C.4 aut |
| 700 | 1 | a Debedat, J.4 aut |
| 700 | 1 | a Djebbar, M.u Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Doré, A.u Université Paris-Saclay,University Paris-Saclay4 aut |
| 700 | 1 | a Engelbrechtsen, L.u Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Fellahi, S.u Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Fromentin, S.u Université Paris-Saclay,University Paris-Saclay4 aut |
| 700 | 1 | a Giral, P.u Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Graine, M.4 aut |
| 700 | 1 | a Hartemann, A.u Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Hartmann, B.u Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Helft, G.u Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Hercberg, S.4 aut |
| 700 | 1 | a Hornbak, M.u Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Isnard, R.u Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Jaqueminet, S.4 aut |
| 700 | 1 | a Jørgensen, N. R.u Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Julienne, H.u Université Paris-Saclay,University Paris-Saclay4 aut |
| 700 | 1 | a Justesen, J.4 aut |
| 700 | 1 | a Kammer, J.u Universität Leipzig,Leipzig University4 aut |
| 700 | 1 | a Kerneis, M.u Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Khemis, J.u Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Krarup, N.u Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Kuhn, M.u European Molecular Biology Laboratory4 aut |
| 700 | 1 | a Lampuré, A.4 aut |
| 700 | 1 | a Lejard, V.u Université Paris-Saclay,University Paris-Saclay4 aut |
| 700 | 1 | a Levenez, F.u Université Paris-Saclay,University Paris-Saclay4 aut |
| 700 | 1 | a Lucas-Martini, L.u Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Massey, R.u Université Paris-Saclay,University Paris-Saclay4 aut |
| 700 | 1 | a Maziers, N.u Université Paris-Saclay,University Paris-Saclay4 aut |
| 700 | 1 | a Medina-Stamminger, J.u Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Moitinho-Silva, L.u European Molecular Biology Laboratory4 aut |
| 700 | 1 | a Montalescot, G.4 aut |
| 700 | 1 | a Moutel, S.u Assistance publique – Hôpitaux de Paris (AP-HP),Universität Leipzig,Leipzig University4 aut |
| 700 | 1 | a Le Pavin, L. P.u Université Paris-Saclay,University Paris-Saclay4 aut |
| 700 | 1 | a Poitou-Bernert, C.4 aut |
| 700 | 1 | a Pousset, F.u Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Pouzoulet, L.4 aut |
| 700 | 1 | a Schmidt, S.4 aut |
| 700 | 1 | a Silvain, J.4 aut |
| 700 | 1 | a Svendstrup, M.u Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Swartz, T.4 aut |
| 700 | 1 | a Vanduyvenboden, T.u Université Paris-Saclay,University Paris-Saclay4 aut |
| 700 | 1 | a Vatier, C.u Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Verger, E.4 aut |
| 700 | 1 | a Walther, S.u Universität Leipzig,Leipzig University4 aut |
| 700 | 1 | a Dumas, M. E.u Imperial College of Science, Technology and Medicine4 aut |
| 700 | 1 | a Ehrlich, S. D.u Université Paris-Saclay,University Paris-Saclay4 aut |
| 700 | 1 | a Galan, P.4 aut |
| 700 | 1 | a Gøtze, J. P.u Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Hansen, T.4 aut |
| 700 | 1 | a Holst, J. J.u Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Køber, L.u Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Letunic, I.u Biobyte Solutions GmbH4 aut |
| 700 | 1 | a Nielsen, Jens B,d 1962u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)nielsenj |
| 700 | 1 | a Oppert, J. M.u Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Stumvoll, M.4 aut |
| 700 | 1 | a Vestergaard, H.u Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Zucker, J. D.4 aut |
| 700 | 1 | a Bork, P.u European Molecular Biology Laboratory4 aut |
| 700 | 1 | a Pedersen, O.4 aut |
| 700 | 1 | a Bäckhed, Fredrik,d 1973u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine,Köpenhamns universitet,University of Copenhagen4 aut0 (Swepub:gu)xbafre |
| 700 | 1 | a Clément, K.4 aut |
| 700 | 1 | a Raes, J.u Katholieke Universiteit Leuven4 aut |
| 710 | 2 | a Katholieke Universiteit Leuvenb European Molecular Biology Laboratory4 org |
| 773 | 0 | t Natured : Springer Science and Business Media LLCg 581:7808, s. 310-315q 581:7808<310-315x 0028-0836x 1476-4687 |
| 856 | 4 | u https://lirias.kuleuven.be/bitstream/123456789/656648/2/Vieira-Silva.Nature.2020.pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/296905 |
| 856 | 4 8 | u https://doi.org/10.1038/s41586-020-2269-x |
| 856 | 4 8 | u https://research.chalmers.se/publication/517357 |
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- Forslund, S. K.
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- Nguyen, T. T. D.
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- Lewinter, C.
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- Camus, M.
- Cassuto, D.
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- Julienne, H.
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