Genome-Wide Association Study for Incident Myocardial Infarction and Coronary Heart Disease in Prospective Cohort Studies: The CHARGE Consortium

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Fältnamn	Indikatorer	Metadata
000		05821naa a2201093 4500
001		oai:DiVA.org:umu-119067
003		SwePub
008		160411s2016 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1190672 URI
024	7	a https://doi.org/10.1371/journal.pone.01449972 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Dehghan, Abbas4 aut
245	1 0	a Genome-Wide Association Study for Incident Myocardial Infarction and Coronary Heart Disease in Prospective Cohort Studies :b The CHARGE Consortium
264		c 2016-03-07
264	1	b Public Library of Science (PLoS),c 2016
338		a print2 rdacarrier
520		a Background Data are limited on genome-wide association studies (GWAS) for incident coronary heart disease (CHD). Moreover, it is not known whether genetic variants identified to date also associate with risk of CHD in a prospective setting. Methods We performed a two-stage GWAS analysis of incident myocardial infarction (MI) and CHD in a total of 64,297 individuals (including 3898 MI cases, 5465 CHD cases). SNPs that passed an arbitrary threshold of 5x10(-6) in Stage I were taken to Stage II for further discovery. Furthermore, in an analysis of prognosis, we studied whether known SNPs from former GWAS were associated with total mortality in individuals who experienced MI during follow-up. Results In Stage I 15 loci passed the threshold of 5x10(-6); 8 loci for MI and 8 loci for CHD, for which one locus overlapped and none were reported in previous GWAS meta-analyses. We took 60 SNPs representing these 15 loci to Stage II of discovery. Four SNPs near QKI showed nominally significant association with MI (p-value<8.8x10(-3)) and three exceeded the genome-wide significance threshold when Stage I and Stage II results were combined (top SNP rs6941513: p = 6.2x10(-9)). Despite excellent power, the 9p21 locus SNP (rs1333049) was only modestly associated with MI (HR = 1.09, p-value = 0.02) and marginally with CHD (HR = 1.06, p-value = 0.08). Among an inception cohort of those who experienced MI during follow-up, the risk allele of rs1333049 was associated with a decreased risk of subsequent mortality (HR = 0.90, p-value = 3.2x10(-3)). Conclusions QKI represents a novel locus that may serve as a predictor of incident CHD in prospective studies. The association of the 9p21 locus both with increased risk of first myocardial infarction and longer survival after MI highlights the importance of study design in investigating genetic determinants of complex disorders.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Allmänmedicin0 (SwePub)302242 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex General Practice0 (SwePub)302242 hsv//eng
700	1	a Bis, Joshua C.4 aut
700	1	a White, Charles C.4 aut
700	1	a Smith, Albert Vernon4 aut
700	1	a Morrison, Alanna C.4 aut
700	1	a Cupples, L. Adrienne4 aut
700	1	a Trompet, Stella4 aut
700	1	a Chasman, Daniel I.4 aut
700	1	a Lumley, Thomas4 aut
700	1	a Voelker, Uwe4 aut
700	1	a Buckley, Brendan M.4 aut
700	1	a Ding, Jingzhong4 aut
700	1	a Jensen, Majken K.4 aut
700	1	a Folsom, Aaron R.4 aut
700	1	a Kritchevsky, Stephen B.4 aut
700	1	a Girman, Cynthia J.4 aut
700	1	a Ford, Ian4 aut
700	1	a Doerr, Marcus4 aut
700	1	a Salomaa, Veikko4 aut
700	1	a Uitterlinden, Andre G.4 aut
700	1	a Eiriksdottir, Gudny4 aut
700	1	a Vasan, Ramachandran S.4 aut
700	1	a Franceschini, Nora4 aut
700	1	a Carty, Cara L.4 aut
700	1	a Virtamo, Jarmo4 aut
700	1	a Demissie, Serkalem4 aut
700	1	a Amouyel, Philippe4 aut
700	1	a Arveiler, Dominique4 aut
700	1	a Heckbert, Susan R.4 aut
700	1	a Ferrieres, Jean4 aut
700	1	a Ducimetiere, Pierre4 aut
700	1	a Smith, Nicholas L.4 aut
700	1	a Wang, Ying A.4 aut
700	1	a Siscovick, David S.4 aut
700	1	a Rice, Kenneth M.4 aut
700	1	a Wiklund, Per-Gunnar,d 1963-u Umeå universitet,Medicin4 aut0 (Swepub:umu)pewi0010
700	1	a Taylor, Kent D.4 aut
700	1	a Evans, Alun4 aut
700	1	a Kee, Frank4 aut
700	1	a Rotter, Jerome I.4 aut
700	1	a Karvanen, Juha4 aut
700	1	a Kuulasmaa, Kari4 aut
700	1	a Heiss, Gerardo4 aut
700	1	a Kraft, Peter4 aut
700	1	a Launer, Lenore J.4 aut
700	1	a Hofman, Albert4 aut
700	1	a Markus, Marcello R. P.4 aut
700	1	a Rose, Lynda M.4 aut
700	1	a Silander, Kaisa4 aut
700	1	a Wagner, Peter4 aut
700	1	a Benjamin, Emelia J.4 aut
700	1	a Lohman, Kurt4 aut
700	1	a Stott, David J.4 aut
700	1	a Rivadeneira, Fernando4 aut
700	1	a Harris, Tamara B.4 aut
700	1	a Levy, Daniel4 aut
700	1	a Liu, Yongmei4 aut
700	1	a Rimm, Eric B.4 aut
700	1	a Jukema, J. Wouter4 aut
700	1	a Voelzke, Henry4 aut
700	1	a Ridker, Paul M.4 aut
700	1	a Blankenberg, Stefan4 aut
700	1	a Franco, Oscar H.4 aut
700	1	a Gudnason, Vilmundur4 aut
700	1	a Psaty, Bruce M.4 aut
700	1	a Boerwinkle, Eric4 aut
700	1	a O'Donnell, Christopher J.4 aut
710	2	a Umeå universitetb Medicin4 org
773	0	t PLOS ONEd : Public Library of Science (PLoS)g 11:3q 11:3x 1932-6203
856	4	u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0144997&type=printable
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-119067
856	4 8	u https://doi.org/10.1371/journal.pone.0144997

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Av författaren/redakt...: Dehghan, Abbas; Bis, Joshua C.; White, Charles C ...; Smith, Albert Ve ...; Morrison, Alanna ...; Cupples, L. Adri ...; visa fler...; Trompet, Stella; Chasman, Daniel ...; Lumley, Thomas; Voelker, Uwe; Buckley, Brendan ...; Ding, Jingzhong; Jensen, Majken K ...; Folsom, Aaron R.; Kritchevsky, Ste ...; Girman, Cynthia ...; Ford, Ian; Doerr, Marcus; Salomaa, Veikko; Uitterlinden, An ...; Eiriksdottir, Gu ...; Vasan, Ramachand ...; Franceschini, No ...; Carty, Cara L.; Virtamo, Jarmo; Demissie, Serkal ...; Amouyel, Philipp ...; Arveiler, Domini ...; Heckbert, Susan ...; Ferrieres, Jean; Ducimetiere, Pie ...; Smith, Nicholas ...; Wang, Ying A.; Siscovick, David ...; Rice, Kenneth M.; Wiklund, Per-Gun ...; Taylor, Kent D.; Evans, Alun; Kee, Frank; Rotter, Jerome I ...; Karvanen, Juha; Kuulasmaa, Kari; Heiss, Gerardo; Kraft, Peter; Launer, Lenore J ...; Hofman, Albert; Markus, Marcello ...; Rose, Lynda M.; Silander, Kaisa; Wagner, Peter; Benjamin, Emelia ...; Lohman, Kurt; Stott, David J.; Rivadeneira, Fer ...; Harris, Tamara B ...; Levy, Daniel; Liu, Yongmei; Rimm, Eric B.; Jukema, J. Woute ...; Voelzke, Henry; Ridker, Paul M.; Blankenberg, Ste ...; Franco, Oscar H.; Gudnason, Vilmun ...; Psaty, Bruce M.; Boerwinkle, Eric; O'Donnell, Chris ...; visa färre...

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